Reta vs Tirz

[Grogu]

woundcarping said:

randompersonrandom said:

For the majority of folks, I'd say tirz is the stronger option at this point; reta suits those with a mild collecting habit.

Tirz comes with longer-term safety and efficacy information, and we've got a solid grasp on titration, adverse effects, dosing — makers have had ample time to refine production, it's been available long enough that the price isn't sky-high, and all in all it's an excellent medication whose mechanism clicks for people who struggle to stop overeating too frequently.

With reta, our current knowledge falls short of what we'd truly need to confirm we're getting product that performs reliably, won't unpredictably break down or develop potency issues after X amount of time, or trigger the sort of severe outcomes we'd catch if it were widely used. It's extremely fresh, and complications and surprises are likely for several years.

It makes complete sense for anyone who's discovered tirz doesn't work for them, yet tirz should genuinely be the first thing most people try, and for many it's the one that fits perfectly.

Another thing worth doing is comparing what you're aiming for against the trial results, then deciding where that leaves you. Say, for instance, your target is dropping 30+% of the weight you started at — then when you set 48-week Reta trial data beside 72-week Tirz data, Reta at least doubles the odds. *At 48 weeks Reta was still climbing, whereas Tirz had already flattened out by 72 weeks.

One concept I'm currently turning over, which came from @Grogu, is that what our bodies grow accustomed to is the peptide over a stretch of time rather than a set dose.... the different dose curves look alike and level off around the same points in time. That runs counter to "low and slow"... though as far as I know, no studies have looked at what happens when you raise the dose past the plateau — tracking weight changes and setting that against simply having been on a larger dose prior to plateauing.

Exactly — there's a gap in the research when it comes to continuing to raise doses during the window where we'd expect these drugs to plateau, and there's nothing at all on switching mechanisms within that same window (say, bringing in an amylin receptor agonist, or phentermine/topiramate, or metformin for that matter).

A while back I saw an interview with Dr. Jastreboff — she led most of the tirzepatide clinical trials — where the question came up about what to do when tirzepatide doesn't get someone to their target weightloss. Her answer was along the lines of: it may depend on how severe a person's obesity is, and if the goal isn't met, more than one medication could be needed. Should one stop working, she'd move that patient onto a different medication.

 

[sheilarae74]

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

With any luck, reta will give you a better energy boost. For most of my time using it, I've dealt with really heavy tiredness. If that weren't an issue, I'd surely be exercising more. If tirz is even harder on fatigue, there's just no chance I could use it.

 

[woundcarping]

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I aim for a defined, deliberate rate of loss: 1% per week, with .9-1.2% as the short-term range I accept, unless something specific explains a shift (for example, a few weeks into TRT I jumped 3lb overnight, and it took a few weeks to come back down).

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

Allodynia showed up for a short stretch. It wasn't disruptive, and had I not known to link it to Reta, I doubt I'd have thought about it enough to bother working it out; it was just a small bodily irritation.

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I was already on Tirz at 5mg/weekly. I used frequent, small doses, aiming to bring my Reta levels into the range where GCGR signaling is reliable, which is estimated at 6-8mg/week at steady state, while avoiding sides deep enough that I'd have to wait them out. Switching from Tirz to Reta went very smoothly and worked well.

To be exact: over the first 18 days I did 12 pins for a total of 21mg; over the first 30 days I did 15 pins for a total of 32mg. During that period I used only 2 doses of Tirz, totaling 4.5mg, to help the transition.

 

[Loscar]

JCO79 said:

That is logical. Perhaps I'm exaggerating how much tirz drains my energy? I do exercise, though summoning the drive is a struggle for me. I'm built more like a buffalo than a squirrel.

Before I can get moving, I need a pre-workout and a mental pep talk. Once that's done, I just dive in! I'm right there with you—I'm built more like a buffalo than a squirrel, and no matter how hard I train, that's how I feel every single morning. I've been using Tirz since Feb.

 

[Fakenamerealwoman]

skunkypotato said:

Speaking as a tirz-only user, fatigue hasn't been a problem in my case — I'm at 10mg and roughly 30 pounds away from my target weight. If anything, I feel more driven to get to the gym. A big part of my struggle was that before starting any glp's, I was putting in gym work but couldn't see the gains because fat was hiding them. Now that the fat is coming off, that effort is finally paying off. Plus, my health markers are all improving. I keep trying to hold myself back from switching to reta, since my current approach is clearly delivering results. The grass isn't always greener elsewhere — or sometimes it's just equally green.

A lot of people have been complaining about anhedonia while on reta. So if you can still experience joy and your sex drive is intact, tirz is probably a great fit for you.

 

[JCO79]

woundcarping said:

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I aim for a defined, deliberate rate of loss: 1% per week, with .9-1.2% as the short-term range I accept, unless something specific explains a shift (for example, a few weeks into TRT I jumped 3lb overnight, and it took a few weeks to come back down).

View attachment 11414

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

Allodynia showed up for a short stretch. It wasn't disruptive, and had I not known to link it to Reta, I doubt I'd have thought about it enough to bother working it out; it was just a small bodily irritation.

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I was already on Tirz at 5mg/weekly. I used frequent, small doses, aiming to bring my Reta levels into the range where GCGR signaling is reliable, which is estimated at 6-8mg/week at steady state, while avoiding sides deep enough that I'd have to wait them out. Switching from Tirz to Reta went very smoothly and worked well.

To be exact: over the first 18 days I did 12 pins for a total of 21mg; over the first 30 days I did 15 pins for a total of 32mg. During that period I used only 2 doses of Tirz, totaling 4.5mg, to help the transition.

View attachment 11415

Woundcarping - what was your reasoning behind that dosing approach when you switched? Were you relying on some sort of pharmacokinetic model, or was it guided by how you felt? If I begin low and raise the dose every 4 weeks, the way I had intended, it could take quite some time before I land on my effective dose.

 

[woundcarping]

JCO79 said:

woundcarping said:

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I aim for a defined, deliberate rate of loss: 1% per week, with .9-1.2% as the short-term range I accept, unless something specific explains a shift (for example, a few weeks into TRT I jumped 3lb overnight, and it took a few weeks to come back down).

View attachment 11414

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

Allodynia showed up for a short stretch. It wasn't disruptive, and had I not known to link it to Reta, I doubt I'd have thought about it enough to bother working it out; it was just a small bodily irritation.

FartfulCodger said:

woundcarping said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

My own situation was different — by week 2 of Tirz at 5mg each week, things weren't like that for me.

A total loss of appetite isn't what I'm after. Eating less and dropping weight is the goal. Tirz never stopped me from eating, and neither does Reta. Going without food is "bad" and it's tough to keep up over the long haul.

Tirz shows up as grey, Reta as pink.





View attachment 11413

That's surprising. You went through 18mg of Reta within 18 days? Honestly, that dosage is outside anything I've tried, and I can see how it would cause rapid weight loss. For me, it would definitely have triggered significant allodynia.

I was already on Tirz at 5mg/weekly. I used frequent, small doses, aiming to bring my Reta levels into the range where GCGR signaling is reliable, which is estimated at 6-8mg/week at steady state, while avoiding sides deep enough that I'd have to wait them out. Switching from Tirz to Reta went very smoothly and worked well.

To be exact: over the first 18 days I did 12 pins for a total of 21mg; over the first 30 days I did 15 pins for a total of 32mg. During that period I used only 2 doses of Tirz, totaling 4.5mg, to help the transition.

View attachment 11415

Woundcarping - what was your reasoning behind that dosing approach when you switched? Were you relying on some sort of pharmacokinetic model, or was it guided by how you felt? If I begin low and raise the dose every 4 weeks, the way I had intended, it could take quite some time before I land on my effective dose.

My goal was steady state levels of 6-8mg without getting slammed by side effects.

I figured that if I used smaller doses, they might build up into noticeable symptoms, yet the spike that pushes me over into feeling those symptoms would stay fairly low and therefore fade fast.

So I went ahead and took doses, checked for side effects (there were basically none), and continued until I reached the level I was aiming for, then switched to dosing 2x weekly.

I began that switch on 1/10, and on 1/17 I took my first 4mg dose, with the second 4mg dose coming 3 days later (2x weekly). I have no notes explaining why, but the following week I used two 3.5mg doses, then 2 4mg doses, and then moved to 5mg on 2/16 and 2/20.

 

[BNLFL]

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

 

[woundcarping]

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

He can see that same spreadsheet with your name listed on it too....

 

[Grogu]

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

Yeah, I knew about that group buy, and I noticed your name plus a few other familiar folks from this community listed on the sheet.

From that GB I picked up 5 kits of cagri, and for weeks I kept going back and forth on the R140. I repeatedly told myself (and others too) that I'd skip it because reta wasn't part of my routine. Then Friday night I started reta. Suddenly everything shifted .

 

[BNLFL]

Grogu said:

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

Yeah, I knew about that group buy, and I noticed your name plus a few other familiar folks from this community listed on the sheet.

From that GB I picked up 5 kits of cagri, and for weeks I kept going back and forth on the R140. I repeatedly told myself (and others too) that I'd skip it because reta wasn't part of my routine. Then Friday night I started reta. Suddenly everything shifted .

Caught me. Even after noticing that 140 in the WW coming soon, I dismissed it entirely. It kept popping up, and once the close was getting near I finally decided to pull the trigger. At 23 cents a mg, I just can't resist.

 

[MrZardoz]

Tirz has been my go-to from the very beginning of my weight loss journey — I went from 322 pounds down to 226 pounds, where I've now hit a standstill. I gave Reta a shot, but no matter how I approached it — whether I eased into it over many months or jumped straight to a massive dose (20mg at the high end) — it produced zero results for me. Why that happens, I honestly can't say. So Tirz is what I'm left with, and I keep wondering what it would feel like to actually drop weight while on Reta...

 

[woundcarping]

MrZardoz said:

Tirz has been my go-to from the very beginning of my weight loss journey — I went from 322 pounds down to 226 pounds, where I've now hit a standstill. I gave Reta a shot, but no matter how I approached it — whether I eased into it over many months or jumped straight to a massive dose (20mg at the high end) — it produced zero results for me. Why that happens, I honestly can't say. So Tirz is what I'm left with, and I keep wondering what it would feel like to actually drop weight while on Reta...

Just wondering... what's your total time on Tirz so far, at what mg did things stall out, and how much further up did you push the dose trying to get past it?

As far as I know, no studies back up raising the dose to boost fat loss once you've hit a plateau, so your firsthand account would be worth hearing.

Another person around your starting weight also stalled on Tirz. Adding sema got things moving again, and they lost roughly another 30lb.

It's strange that Reta does nothing for you — odd and unlucky.

ETA: I'm reading back through your earlier posts to pick up some useful details.

 

[MrZardoz]

Started Tirz roughly July 2025 (I believe). On the dosing side, I'd already moved past 15mg up to roughly 20mg, give or take. These days I'm at about 33mg each week, and cagrill has been part of the mix too (doses anywhere from 5mg up to 20mg). Over the top, sure, but I suppose that fits me.

Lately I've been considering adding another 12.5 of brand name Tirz (which I receive free, meant to pair with my grey Tirz). For a few months now I've been sitting near 225, give or take about 5 pounds, and I'm not sure what to do to get the weight loss moving again...

 

[woundcarping]

MrZardoz said:

Started Tirz roughly July 2025 (I believe). On the dosing side, I'd already moved past 15mg up to roughly 20mg, give or take. These days I'm at about 33mg each week, and cagrill has been part of the mix too (doses anywhere from 5mg up to 20mg). Over the top, sure, but I suppose that fits me.

Lately I've been considering adding another 12.5 of brand name Tirz (which I receive free, meant to pair with my grey Tirz). For a few months now I've been sitting near 225, give or take about 5 pounds, and I'm not sure what to do to get the weight loss moving again...

I went through the bulk of what you've written... you mentioned that math isn't your strong suit and that writing is your natural bent or your profession.

Across roughly 33 weeks₁, your weight loss has stalled at 29% (97lb) while dosing Tirz as high as 33mg/week (220% of the max trial dose). Along the way you added at least 2mg of Sema on top of 28mg/week Tirz. You've also run Reta "slow" and at doses reaching 20mg/week (166% of the max trial dose) without results, plus Cagri ranging from 5-20mg (444% of the highest trialed dose, 833% of the usual 2.4mg ceiling)..

My read is that you're either a unicorn, the math isn't mathing, you're full of shit, or some mix of those. I've never come across a unicorn.

₁ Taking a start date of 7/17/2025 and subtracting 8 weeks for the "couple of month" stall.

 

[MrZardoz]

Appreciate you digging into my history. As for how long I've been on Tirz, I couldn't tell you - and "unicorn"? No clue what that means, and honestly I'm not about to look it up.

That said, it did cross my mind to double-check the dose, and I did get 1 big thing wrong: on my insulin syringes it's 33'u' - not milligrams. My mistake, sorry about that.

As for me being full of shit? Guilty, always.

On the math side - I truly don't know how long this plateau has gone on. I'm finally taking the time to go through my 'Monitor Your Weight' app for the daily numbers. April 26 is the day I hit 225pounds for the first time... (I suppose it just feels much longer when you're weighing yourself every day...)

And yes, that start date is right. Math has never been my strong suit, I never graduated, and on top of that I'm currently on the far side of a stroke that cost me 1 of my carotid arteries and did who-knows-what to my brain and mind - even so, I keep on top of most things fairly well.

 

[Grogu]

MrZardoz said:

Appreciate you digging into my history. As for how long I've been on Tirz, I couldn't tell you - and "unicorn"? No clue what that means, and honestly I'm not about to look it up.

That said, it did cross my mind to double-check the dose, and I did get 1 big thing wrong: on my insulin syringes it's 33'u' - not milligrams. My mistake, sorry about that.

As for me being full of shit? Guilty, always.

On the math side - I truly don't know how long this plateau has gone on. I'm finally taking the time to go through my 'Monitor Your Weight' app for the daily numbers. April 26 is the day I hit 225pounds for the first time... (I suppose it just feels much longer when you're weighing yourself every day...)

And yes, that start date is right. Math has never been my strong suit, I never graduated, and on top of that I'm currently on the far side of a stroke that cost me 1 of my carotid arteries and did who-knows-what to my brain and mind - even so, I keep on top of most things fairly well.

I'm curious — what's your actual tirzepatide dose? You brought up mixing up 33 units with 33 milligrams, and considering the peptide ranges you listed, milligrams would line up better. Taking cagrilintide somewhere between 5mg and 20mg would be pretty far out there. Hitting a stall at 8 months seems a bit early to me. Maybe the answer is simply to increase your tirzepatide dose.

 

[X3rocks]

BNLFL said:

Grogu said:

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

Yeah, I knew about that group buy, and I noticed your name plus a few other familiar folks from this community listed on the sheet.

From that GB I picked up 5 kits of cagri, and for weeks I kept going back and forth on the R140. I repeatedly told myself (and others too) that I'd skip it because reta wasn't part of my routine. Then Friday night I started reta. Suddenly everything shifted .

Caught me. Even after noticing that 140 in the WW coming soon, I dismissed it entirely. It kept popping up, and once the close was getting near I finally decided to pull the trigger. At 23 cents a mg, I just can't resist.

I need to ask: does that vial really hold 140mg? At 5mg per dose, that works out to 28 weeks — how does it stay stable that long? Is there something I'm overlooking?

 

[woundcarping]

X3rocks said:

BNLFL said:

Grogu said:

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

Yeah, I knew about that group buy, and I noticed your name plus a few other familiar folks from this community listed on the sheet.

From that GB I picked up 5 kits of cagri, and for weeks I kept going back and forth on the R140. I repeatedly told myself (and others too) that I'd skip it because reta wasn't part of my routine. Then Friday night I started reta. Suddenly everything shifted .

Caught me. Even after noticing that 140 in the WW coming soon, I dismissed it entirely. It kept popping up, and once the close was getting near I finally decided to pull the trigger. At 23 cents a mg, I just can't resist.

I need to ask: does that vial really hold 140mg? At 5mg per dose, that works out to 28 weeks — how does it stay stable that long? Is there something I'm overlooking?

A 5mg dose is beginner territory.

Certain people split vials between them.

I own an X3 RR RC as well.

 

[lessthanhalf]

Before I ever touched a GLP, I had already dropped from 145kg down to 75 kg, and binge eating / food addiction was definitely something I struggled with.

How did I do it? By cutting out anything high calorie, highly rewarding, or high on the glycemic index entirely. My diet was very high protein, low fat, and low in calorific density — lean meat, vegetables, fruit, low fat dairy.

The weight stayed off for a year. Then I started ozempic, which took the edge off my appetite and left me somewhat nauseous for a year. After that I moved to tirzepatide 15mg, which brought less nausea and less hunger, and I added 5mg of reta on top. That combination largely solved the constant hunger, but I still refuse to touch those high calorie foods. In the past, even tiny amounts set off intense hunger an hour or 2 later — I assume it's tied to blood glucose spikes and the dips that follow, flipping some kind of extreme hunger switch.

Maybe I could try some of those foods again now, but I won't take the chance. That problem has driven fairly extreme weight regain for me before, and regaining carries fairly extreme health risks.

Your situation may be very different, but I'll be curious to see how it goes when you reintroduce some of the foods you currently avoid after adding in GLP's.