Reta Triumph 1: New Results
- Thread starter m100568
- Start date
FarmgirlRebel
Explorer
Interesting.
At 80 weeks, 4mg and 12mg show a clear gap in weight loss.
Yet when you look ahead to 104 weeks, those gaps become largely negligible, particularly when comparing 4mg with 9mg.
At 80 weeks, 4mg and 12mg show a clear gap in weight loss.
Yet when you look ahead to 104 weeks, those gaps become largely negligible, particularly when comparing 4mg with 9mg.
PinKushn
Explorer
What explains the placebo arm climbing from 2% all the way to 19%??
Some comments from a blogger who participated in the trial.
alphaamigo
Explorer
It stands out to me that people whose weight loss appeared to plateau at 4mgs could, during the final 24 weeks, increase their dose and come close to matching the top dose.
woundcarping
Explorer
This was achieved through administration of 9-12mg of Reta.
mybodyisasewer
Explorer
This is a matter of national security.
The US DoD has to ensure gen Z gets access to this stuff so they can meet fitness standards for service.
The CCP is the one selling us the drugs that would strengthen the draft pool of their opponent.
Somehow the US seems fine letting its kids stay fat, while the Chinese are fine making them fit.
That's what puzzles the patriot.
The US DoD has to ensure gen Z gets access to this stuff so they can meet fitness standards for service.
The CCP is the one selling us the drugs that would strengthen the draft pool of their opponent.
Somehow the US seems fine letting its kids stay fat, while the Chinese are fine making them fit.
That's what puzzles the patriot.
Appreciate you sharing this. What stands out is that the placebo arm dropped 17% of body weight (from 19.2% down to 2.2% at week 80) between week 80 and week 104 — a span of only 24 weeks. Meanwhile the 4mg arm managed just 19% across 80 weeks, which is more than a year longer than the placebo arm. It seems obvious the placebo group escalated dose fast and shed pounds fast, ending up matching the 4mg group's 2-year total weight loss. That is genuinely wild.
Smiter
Explorer
I'm really curious whether the placebo they used included some kind of MEGA-LAXATIVE
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
. Right now, I would happily accept an extra 3.4% of weight loss….
25MG of Tirzepatide, coming through, make some room
. Right now, I would happily accept an extra 3.4% of weight loss….
Smiter
Explorer
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
still, the placebo details look very sketchy to me.Smiter said:
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
True, a 17% drop across 24 weeks does look quite striking. Still, once week 80 rolled around, those folks were so frantic about dropping pounds that they basically launched a hunger strike
.
Smiter
Explorer
Sounds less like despair and more like they swiped a stash of Reta vials and launched into a stabbing rampage.Grogu said:
Smiter said:
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
True, a 17% drop across 24 weeks does look quite striking. Still, once week 80 rolled around, those folks were so frantic about dropping pounds that they basically launched a hunger strike
woundcarping
Explorer
Smiter said:
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
Are you aware that the placebo arm was switched to Reta at the 80-week mark, which led to weight loss in those participants?
In a separate trial, didn’t the 12mg cohort achieve a 24% reduction over 48 weeks?
FarmgirlRebel
Explorer
Yeah, I get it...strange. The placebo response is definitely genuine.
Smiter
Explorer
That's the reason the study methods struck me as questionable. If they actually received the genuine medication, what justifies labeling them a placebo group? And on top of that, a few suggest they got the drug afterward and then experienced massive weight reduction...To me, all of that looked wrong.woundcarping said:
Smiter said:
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
Are you aware that the placebo arm was switched to Reta at the 80-week mark, which led to weight loss in those participants?
In a separate trial, didn’t the 12mg cohort achieve a 24% reduction over 48 weeks?
woundcarping
Explorer
The control group is the placebo group… until the test variable is introduced, every participant belongs to the control group… Those who began receiving Reta at 80 weeks had been part of the control group up to that point. Think of it as back-to-back trials, where the control groups for the placebo and the lower dose escalation trials run at the same time.Smiter said:
That's the reason the study methods struck me as questionable. If they actually received the genuine medication, what justifies labeling them a placebo group? And on top of that, a few suggest they got the drug afterward and then experienced massive weight reduction...To me, all of that looked wrong.woundcarping said:
Smiter said:
They have more to kill/
Grogu said:
One more MASSIVE point from the phase 3 top line data: even when the dose increase happened at week 80, continuing to titrate upward still yielded extra weight reduction through week 104 (2 years). Absolutely YEAH! As expected, this effect was stronger among the 4mg group than the 9mg group. Still, for those on 9mg, going up at week 80 through week 104 gave close to another 3.4% of loss.
25MG of Tirzepatide, coming through, make some room
Are you aware that the placebo arm was switched to Reta at the 80-week mark, which led to weight loss in those participants?
In a separate trial, didn’t the 12mg cohort achieve a 24% reduction over 48 weeks?