I've been wondering whether taking small doses each day would pay off more over time — the idea being that it accumulates gradually and keeps appetite more level, and so on. Anyone have opinions on this? Has anybody actually given it a go? So far I've been doing it once or twice per week.
Reta daily?
- Thread starter Slaine
- Start date
Shittersfull
Explorer
In my opinion, that's far too much. Doing it 2x a week has some benefit, but going beyond that is simply over the top.
plant_lady
Explorer
Perhaps combine it with Tirz or Cag rather than using it alone (to help curb appetite)?
littlerestraint
Explorer
I gave it some thought, but in the end I chose to dose twice a week.
Mochizuki0124
Explorer
Microdosing doesn't apply here the way it does with testosterone.
Abrakebabra
Explorer
Like other people have mentioned, I don't personally see daily dosing bringing huge advantages - going with 2 or 3x a week strikes me as the more logical route if you want fewer sides, though beyond that I'd guess the returns start shrinking. That's just my opinion, and I'm sure plenty of others would argue otherwise. At the end of the day, it comes down to whatever suits you. If you fancy trying it, go for it - it probably won't cause any problems either!
woundcarping
Explorer
For a big chunk of people, I can't find any upside here, though it won't affect your receptors.
Least payoff, most inconvenience.
Least payoff, most inconvenience.
bada bing
Explorer
For a maintenance schedule, once a day is more than necessary. There is a role for it while you're hunting for an effective blood level during the start or when titrating up, but that applies only to the step-up phase. I've used it that way before, and it does work.
BNLFL
Explorer
All it will do is give you extra puncture sites. Where on earth did this notion originate?
woundcarping
Explorer
A small amount works well, and a larger amount could work even better.
Elite
Explorer
Splitting it into 2 doses per week is giving great results, even at low amounts.
lessthanhalf
Explorer
I dose reta and tirz every other day. The main reason is that I started out on ozempic at low doses, and to cut down on really unpleasant side effects I had to take very small doses often, so when I switched I simply kept doing it that way. There is another factor too: I am already at the highest doses I can tolerate, roughly tirz 4mg and reta 2.4mg every second day. Even a tiny bump in either one makes the sensory symptoms in my skin much worse, so raising the dose and spacing it out further probably is not something I could manage. On top of that, I am working at holding onto a 56% weight loss.
That said, weekly dosing is simple to keep track of, and since these drugs have a half life of about a week, there ought to be a rationale for injecting more often. Typically it comes down to one of 2 things: either the effects appear to fade in under a week and upping the dose does not solve that, or side effects are worse in the day or 2 following a dose, which splitting the dose can ease because every peak in blood level ends up smaller ( or the dose can simply be lowered ). So unless side effects that vary depending on how long ago the last dose was are causing trouble, or hunger control swings too much, dosing more frequently is not really necessary.
CrimsonTaco47
Explorer
A lot of folks seem to overlook the fact that the half life on these meds runs about 6 days. So even if you're pinning every single day, what you inject per shot is only one piece of the puzzle. From my own testing — I used to dose every 3 days and have moved to every 4 days — what really catches up with you is how much has built up in your body at any given moment.
Take a daily dose of .25mg. That adds up to just 1.75mg across a week. Sounds small, sure, but that figure only reflects what goes in, not what's lingering inside you. With a half-life near 6 days, yesterday's shot is mostly still around when today's goes in, and the day before that is largely still there as well. So each tiny daily pin keeps piling on top of the last.
At .25 mg per day, a few weeks in you'd be sitting at about 2.25 mg in your system almost constantly. Nobody's claiming you're injecting 2 mg a day, but by the same token your body isn't only seeing .25 mg at a time either.
That's what I think people miss about daily microdosing. The peaks and valleys would be gentler, but you'd also essentially never hit much of a low point. I'd question whether holding the drug that steadily elevated might actually produce more persistent side effects for certain people, instead of fewer by default just because each individual shot is small.
Take a daily dose of .25mg. That adds up to just 1.75mg across a week. Sounds small, sure, but that figure only reflects what goes in, not what's lingering inside you. With a half-life near 6 days, yesterday's shot is mostly still around when today's goes in, and the day before that is largely still there as well. So each tiny daily pin keeps piling on top of the last.
At .25 mg per day, a few weeks in you'd be sitting at about 2.25 mg in your system almost constantly. Nobody's claiming you're injecting 2 mg a day, but by the same token your body isn't only seeing .25 mg at a time either.
That's what I think people miss about daily microdosing. The peaks and valleys would be gentler, but you'd also essentially never hit much of a low point. I'd question whether holding the drug that steadily elevated might actually produce more persistent side effects for certain people, instead of fewer by default just because each individual shot is small.
Calm Logic
Explorer
In the same way, taking it every day doesn't appear to offer an advantage over EOD when it comes to aggressive titration, or for what Gemini refers to as "titration agility."
BNLFL
Explorer
Shots don't bother me at all. What I can't wrap my head around is the appeal of injecting every single day when there's genuinely no need for it. That said, I get that people on insulin have no choice.
Calm Logic
Explorer
Completely off-topic, but about 10 years back a wife murdered her husband by contaminating his steroid vials with antifreeze:
Wife gets 40 years for putting antifreeze in husband’s steroids
DOVER, Del. — A Delaware woman who killed her weightlifter husband by putting antifreeze into his steroid injections has been sentenced to 40 years in prison. The News Journal reports that a state …
Which makes you think — had he been injecting smaller amounts every day, he might still be alive. And if peptides had been his thing, she had another option: Visine.