Reta cancer data drops

TooGood76

TooGood76

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Ok I'm sharing the twitter link since the wsj piece sits behind a pay wall and this summarizes it.

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.

And today the cancer signal drops.

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%).… https://t.co/wqMGXWckw0

— Avi Roy (@agingroy) May 22, 2026
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View: https://⚠scam Site⚠️/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
 
Ideally, research along these lines will one day pin down the actual driver behind the whole cluster of issues — the metabolic syndrome components already recognized, joint pain, mental health imbalance, cancer — all of which GLP-1 endruns ease. Still, my view is that a shortage of natural GLP-1 availability is plainly not the root cause.
 
Honestly, every single thing I come across on this site pushes me closer to jumping on the reta bandwagon
 
lil ghost said:

Honestly, every single thing I come across on this site pushes me closer to jumping on the reta bandwagon
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Lilly is already bringing private investigators on board and working alongside authorities to confiscate peptide shipments nationwide, so if you're thinking about joining in, do it right away. Things will only deteriorate going forward. Purchase today, build up your supply, and keep an eye on how this unfolds.
 
lil ghost said:

Honestly, every single thing I come across on this site pushes me closer to jumping on the reta bandwagon
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It's no mystery that Reta has my affection — my avatar is literally a Reta molecule. Still, should the FDA give in and reclassify Reta as a biologic (cue the magic wand), the resulting crackdown would be even harsher than the current one, and that's already quite severe.
 
TooGood76 said:


these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.

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The mechanism is likely tied to what happens while weight is coming off, rather than to the lower number on the scale itself — or so the thinking goes. Cut off the body’s fuel supply, and you also cut off the tumor’s. That means the effect probably comes from the active process of shedding pounds, which bears on cancers that are already present, instead of from the eventual drop in weight, which would more plausibly lower the incidence of new cancers.
 
5byfive said:


Actually, the effects are probably directly driven by the weight loss process (at least thats the theory). When you deprive the body of fuel, you deprive the cancer of fuel. So not the reduction in weight, which would be likely to reduce the rate of new cancers, but the process of losing weight which is impacting existing cancer growth.

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I was thinking the same thing. It's easy to overlook that obesity itself carries health risks on multiple fronts — among them, having more body fat is tied to a higher likelihood of developing several types of cancer.

That means simply reaching a healthier weight already comes with a long list of health advantages.

Regardless, the phase 3 findings are intriguing, and I appreciate you posting them.
 
5byfive said:


Actually, the effects are probably directly driven by the weight loss process (at least thats the theory). When you deprive the body of fuel, you deprive the cancer of fuel. So not the reduction in weight, which would be likely to reduce the rate of new cancers, but the process of losing weight which is impacting existing cancer growth.

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What they're observing goes beyond what plain weight reduction would explain. Blood glucose management plays a role here—that's also why metformin gets prescribed in oncology—but additional mechanisms are at work. On glps, inflammatory markers fall much more rapidly than with comparable caloric deficits or fasting periods, and Reta clears liver fat to a degree that exceeds what weight loss by itself would achieve, among other things.
 
TooGood76 said:


Ok I'm posting the twitter link bc the wsj article is pay walled and it summarizes it.

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.

And today the cancer signal drops.

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%).… https://t.co/wqMGXWckw0

— Avi Roy (@agingroy) May 22, 2026
Click to expand...

View: https://⚠scam Site⚠️/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.

Click to expand...
Click to expand...
Where can I find the paper or the data?
 
The overall takeaway is that obesity/overweight is behind the majority of health problems. That is entirely logical.
 
Habibibi said:

TooGood76 said:


Ok I'm posting the twitter link bc the wsj article is pay walled and it summarizes it.

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.

And today the cancer signal drops.

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%).… https://t.co/wqMGXWckw0

— Avi Roy (@agingroy) May 22, 2026
Click to expand...

View: https://⚠scam Site⚠️/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.

Click to expand...
Click to expand...
Where can I find the paper or the data?
Click to expand...
There's additional substance at https://www.targetedonc.com/view/gl...or-reduction-in-metastatic-cancer-progression ... however it appears specifics are being held back until the presentation happening in the next week (today?)
 
lil ghost said:

Honestly, every single thing I come across on this site pushes me closer to jumping on the reta bandwagon
Click to expand...
Go for it.

Really fascinating stuff — I'm eager to hear more.
 
About a year back, I came across a study involving bowel cancer patients — those taking GLP drugs survived considerably longer than patients who weren't. Should this pattern continue to be validated, GLP-1 agonists could turn out to be a highly effective cancer therapy, or at minimum remarkably capable of stopping it from spreading. According to this study, across several different cancers, metastases (secondary tumours) occurred at only half the rate among those on GLPs. A lot of cancer treatment drugs don't perform that well and usually come with far worse side effects. On top of that, it likely prevents many cancers from developing in the first place. Those results are more than strong enough to justify large scale prospective clinical trials to confirm the effect is genuine.
 
lessthanhalf said:

About a year back, I came across a study involving bowel cancer patients — those taking GLP drugs survived considerably longer than patients who weren't. Should this pattern continue to be validated, GLP-1 agonists could turn out to be a highly effective cancer therapy, or at minimum remarkably capable of stopping it from spreading. According to this study, across several different cancers, metastases (secondary tumours) occurred at only half the rate among those on GLPs. A lot of cancer treatment drugs don't perform that well and usually come with far worse side effects. On top of that, it likely prevents many cancers from developing in the first place. Those results are more than strong enough to justify large scale prospective clinical trials to confirm the effect is genuine.
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here we have yet another case of discovering that these medications have an effect, and only afterward working backward to pin down the precise mechanism behind it
 
lessthanhalf said:

About a year back, I came across a study involving bowel cancer patients — those taking GLP drugs survived considerably longer than patients who weren't. Should this pattern continue to be validated, GLP-1 agonists could turn out to be a highly effective cancer therapy, or at minimum remarkably capable of stopping it from spreading. According to this study, across several different cancers, metastases (secondary tumours) occurred at only half the rate among those on GLPs. A lot of cancer treatment drugs don't perform that well and usually come with far worse side effects. On top of that, it likely prevents many cancers from developing in the first place. Those results are more than strong enough to justify large scale prospective clinical trials to confirm the effect is genuine.
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Why didn't <50% show up here, I thought to myself. Timing, right? I can just picture you biting into a thick Cuban cigar, grinning with that satisfied look and a little nod, as you go through this thread. But your thoughts on what lies ahead for the grey zone if Reta gets official approval—I still haven't come across them. For regular folks like us, what shifts do you think are coming?
 
TooGood76 said:

Ok I'm sharing the twitter link since the wsj piece sits behind a pay wall and this summarizes it.

Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.

And today the cancer signal drops.

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%).… https://t.co/wqMGXWckw0

— Avi Roy (@agingroy) May 22, 2026
Click to expand...

View: https://⚠scam Site⚠️/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg

12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
Click to expand...
Saved version: https://archive.is/lCH6N
 
Smiter said:

lessthanhalf said:

About a year back, I came across a study involving bowel cancer patients — those taking GLP drugs survived considerably longer than patients who weren't. Should this pattern continue to be validated, GLP-1 agonists could turn out to be a highly effective cancer therapy, or at minimum remarkably capable of stopping it from spreading. According to this study, across several different cancers, metastases (secondary tumours) occurred at only half the rate among those on GLPs. A lot of cancer treatment drugs don't perform that well and usually come with far worse side effects. On top of that, it likely prevents many cancers from developing in the first place. Those results are more than strong enough to justify large scale prospective clinical trials to confirm the effect is genuine.
Click to expand...
Why didn't <50% show up here, I thought to myself. Timing, right? I can just picture you biting into a thick Cuban cigar, grinning with that satisfied look and a little nod, as you go through this thread. But your thoughts on what lies ahead for the grey zone if Reta gets official approval—I still haven't come across them. For regular folks like us, what shifts do you think are coming?
Click to expand...

Once approved, Tirz and Sema saw lower prices and wider availability. Sure, there's endless chatter about "crack downs," but my honest take is that those efforts mostly target compounders. When you stack that against the huge number of folks who simply get a script and pay for GLP1s by credit card, the crowd sourcing peptides from china with crypto via telegram is a tiny slice of the market.
 
I think the folks who say these results are merely a byproduct of weight loss are oversimplifying things. I've come across reports of comparable outcomes beyond what you'd normally anticipate from weight loss alone more than once.

I also recall a Dr Attia podcast where he said it's actually unclear whether obesity itself is what causes cancer, and his view is that it isn't. Instead, something like insulin resistance might be the real driver.
 
I really wish my body could handle Reta. The problem is it triggers pain in my gall bladder that radiates into my back and shoulder. So it looks like I will be sticking with Tirz for the long haul.
 
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