Reta and post-surgery discussion

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LlamaWorm

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I've been using Reta for 1 month. I've lost about 20 lbs, which makes me really happy. I have a big surgery scheduled for July, and my doctor instructed me to stop my GLP. They aren't aware of which specific one I take and only asked whether it was compounded; I answered yes. I need to stop 1 week before the procedure, and I wasn't clearly told when I could resume. I realize one concern involves slower digestion before surgery and anesthesia.

What I want to know is how many people resumed AFTER surgery, and how long did you wait? My main worry is the oxy I'll be taking and whether it digests more slowly and leads to problems?

Any thoughts or experiences?
 
The worry here is that when the stomach empties slowly, acid lingers there longer, which raises the chance that some of it gets into your lungs while you're under anaesthesia. Oddly enough, the majority of research so far doesn't appear to point to a higher rate of pneumonia after surgery, so recommendations differ between locations. Many studies indicate improved results for surgical patients who are on glp medications, while a smaller number indicate poorer ones, yet on the whole resuming it shortly is not likely to cause harm, though my advice would be to hold off until you've left the hospital.

Am I right in thinking you're referring to oxycodeine when you say oxy, as a painkiller after surgery? For my chronic gut pain from UC/IBS I use tramadol, and GLP's definitely delay how quickly drugs are absorbed by a substantial amount; the overall dose absorbed over time isn't really altered, but if you swallow it orally it will take longer before it kicks in, at times by several hours. The main reason is that the pills simply remain in the stomach without being absorbed for a period before finally being passed to the intestines, where absorption can begin, because of that same slowed gastric emptying. Should you be on a regular dosing schedule, it probably won't make much difference, but it could become a problem if you only take them once the pain worsens, since onset will be delayed. That said, GLP drugs lower your odds of becoming addicted to opiates, so there's that upside.
 
Thanks 🙂 Yes, I'm talking about Oxycodone. I haven't taken it before, so I don't know what it will be like. Still, what you said about absorption being slower makes sense. My main worry was how it would change the actual effect—whether the drug would end up feeling stronger or wouldn't work at all—so that puts my mind at ease.
 
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