Reta and non hospital bac

Nate2plate

Nate2plate

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Short background. From one of the pricier vendors (this was before we knew better) we picked up 1 vial of reta, reconstituted it with hospira, and the results were excellent.

Then we bought a kit from a source that appears highly reputable, with plenty of positive feedback and group testing supporting the product. Their BAC water was part of the same order.

After mixing the kit (not chilled, and rolled gently in the palms), the solution looked good. Clear, as expected. We dosed it and it appeared to work. The effect felt somewhat different, yet fat loss kept going and inflammation continued dropping, etc. I wasn’t as nauseated by it, though I assumed that was because week three had arrived and the dose was no longer new.

When the second dose was drawn from that vial, it had turned cloudy. I put it aside, reconstituted a second vial, and that one also became cloudy once it sat. Roll it again and it clears up.

A little of the earlier reta was still on hand, so we combined it with the new BAC and it looks okay so far, but we’re waiting to see whether cloudiness returns.

Is needing another roll to clear things out typical? Could the new bac have a PH problem?

Hospira is already on the way, and I’ll test the new Reta batch with it.

Hopefully this is all clear!
 
Try checking the pH of your fresh bac with a test strip. That's likely where the problem lies. Should the pH come back normal, get in touch with the supplier.
 
Nate2plate said:

Short background. From one of the pricier vendors (this was before we knew better) we picked up 1 vial of reta, reconstituted it with hospira, and the results were excellent.

Then we bought a kit from a source that appears highly reputable, with plenty of positive feedback and group testing supporting the product. Their BAC water was part of the same order.

After mixing the kit (not chilled, and rolled gently in the palms), the solution looked good. Clear, as expected. We dosed it and it appeared to work. The effect felt somewhat different, yet fat loss kept going and inflammation continued dropping, etc. I wasn’t as nauseated by it, though I assumed that was because week three had arrived and the dose was no longer new.

When the second dose was drawn from that vial, it had turned cloudy. I put it aside, reconstituted a second vial, and that one also became cloudy once it sat. Roll it again and it clears up.

A little of the earlier reta was still on hand, so we combined it with the new BAC and it looks okay so far, but we’re waiting to see whether cloudiness returns.

Is needing another roll to clear things out typical? Could the new bac have a PH problem?

Hospira is already on the way, and I’ll test the new Reta batch with it.

Hopefully this is all clear!
Click to expand...
Next time, don't throw money away on bac water from a vendor. To confirm it's got the correct pH, the proper ingredient levels, the right kind of water, and so on, you'd need to test it. And you'd have to repeat that for each batch.
 
If you're not using Hospira, cloudy issues tend to show up more often.

Vendor BAC should be avoided completely: it isn't sterile, endotoxin levels are high, and the BA% and PH are either incorrect or missing. Like mentioned, get in touch with the vendor—they ought to swap it out because you were injecting their toilet water.
 
Cloudiness has never happened to me with anything, though hospira is the only one I've used.

RetCurious said:

If you're not using Hospira, cloudy issues tend to show up more often.

Vendor BAC should be avoided completely: it isn't sterile, endotoxin levels are high, and the BA% and PH are either incorrect or missing. Like mentioned, get in touch with the vendor—they ought to swap it out because you were injecting their toilet water.
Click to expand...
 
What's the concentration? Once you took it out of the fridge, did you warm it in your hands? (Were you careful to keep it refrigerated?)
 
eidos said:

What's the concentration? Once you took it out of the fridge, did you warm it in your hands? (Were you careful to keep it refrigerated?)
Click to expand...

It stayed in the fridge the whole time, and I did let it warm in my hands. Over on the vendor's Discord, someone else running the same batch number hit the identical problem, and switching to hospira cleared it up for them. My hospira shows up tomorrow, so I'll report back on how it goes.

Hoping for the best — definitely a lesson learned!
 
Nate2plate said:

eidos said:

What's the concentration? Once you took it out of the fridge, did you warm it in your hands? (Were you careful to keep it refrigerated?)
Click to expand...

It stayed in the fridge the whole time, and I did let it warm in my hands. Over on the vendor's Discord, someone else running the same batch number hit the identical problem, and switching to hospira cleared it up for them. My hospira shows up tomorrow, so I'll report back on how it goes.

Hoping for the best — definitely a lesson learned!
Click to expand...
Alright.

It's likely a pH problem, as in the solution is too acidic — that's what @RetCurious suggested.

Whenever I get a BAC vial, I check its pH (putting a few drops on pH paper that reads to a quarter of a unit gives a clear enough answer). Because of the pH drift that can happen with time, plus what Pfizer says in the SDS, testing your Hospira is something everyone ought to do too.

According to Lilly's patents, the isoelectric point sits under 6.5, and comparing it with Tirz and Sema, going below 5 seems probable.

Some BACs I've used came in at 5.5, while others measured 6.5. For the Reta, the ones I reach for are the 6.5 (less acidic) vials.

A sterile PBS (phosphate buffer) order is on its way, which should bring things nearer to the formulation Lilly uses in its pens. More to come.
 
Nate2plate said:

Short background. From one of the pricier vendors (this was before we knew better) we picked up 1 vial of reta, reconstituted it with hospira, and the results were excellent.

Then we bought a kit from a source that appears highly reputable, with plenty of positive feedback and group testing supporting the product. Their BAC water was part of the same order.

After mixing the kit (not chilled, and rolled gently in the palms), the solution looked good. Clear, as expected. We dosed it and it appeared to work. The effect felt somewhat different, yet fat loss kept going and inflammation continued dropping, etc. I wasn’t as nauseated by it, though I assumed that was because week three had arrived and the dose was no longer new.

When the second dose was drawn from that vial, it had turned cloudy. I put it aside, reconstituted a second vial, and that one also became cloudy once it sat. Roll it again and it clears up.

A little of the earlier reta was still on hand, so we combined it with the new BAC and it looks okay so far, but we’re waiting to see whether cloudiness returns.

Is needing another roll to clear things out typical? Could the new bac have a PH problem?

Hospira is already on the way, and I’ll test the new Reta batch with it.

Hopefully this is all clear!
Click to expand...
So what's going on here? You added fresh BAC to Reta that had already been reconstituted? If that's what happened, the concentration would end up massively watered down.
 
Nate2plate said:

eidos said:

What's the concentration? Once you took it out of the fridge, did you warm it in your hands? (Were you careful to keep it refrigerated?)
Click to expand...

It stayed in the fridge the whole time, and I did let it warm in my hands. Over on the vendor's Discord, someone else running the same batch number hit the identical problem, and switching to hospira cleared it up for them. My hospira shows up tomorrow, so I'll report back on how it goes.

Hoping for the best — definitely a lesson learned!
Click to expand...
If the water came from the vendor, then make chase swap out anything you mixed using it
 
So far, this has never happened to me. Both Hospira and Lambda are what I use, and neither one has given me any problems.
 
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