MakeNoPeaceWithEvil
Explorer
Is there anyone here taking Retatrutide, or does anyone know a person taking it, who has undergone CABG/heart bypass surgery?
Reta and Bypass
- Thread starter MakeNoPeaceWithEvil
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Good-Heart6425
Explorer
No, I'm not aware of anyone using Retatrutide who has undergone Coronary Arterial Bypass Graft Surgery after the operation. That said, your question got me curious, and it led me to a retrospective study involving 820 post-CABG patients and GLP1 receptor agonists. https://www.cureus.com/articles/425...bg-in-adults-with-congenital-heart-disease#!/
What they found: "In adult CHD patients undergoing CABG, perioperative use of GLP-1 receptor agonists was associated with a significant reduction in one-year hospital readmission rates, without increased risk of mortality, postoperative complications, or known GLP-1-related adverse events."
What they found: "In adult CHD patients undergoing CABG, perioperative use of GLP-1 receptor agonists was associated with a significant reduction in one-year hospital readmission rates, without increased risk of mortality, postoperative complications, or known GLP-1-related adverse events."
MakeNoPeaceWithEvil
Explorer
Gemini gave me the same details, but the thing that worries me most is the rise in RHR caused by glucagon with reta. This is for my dad — 6months after surgery, he's bounced back really well, though he's gained some weight and his blood test numbers came back slightly above range. The doctor said glp1/2 should be fine, but warned him to avoid retatrutide (since "retatrutide (because there is no such thing as "GLP-3")" doesn't exist). Hearing the doc use that phrasing cracked me up, but I broke it down for my dad.
MakeNoPeaceWithEvil
Explorer
Wait, did the forum reply alter how my post was written??
Good-Heart6425
Explorer
What your dad's doctor suggested has a basis in evidence. . look at this
As of March 3, 2026, this is the page: science media centre > roundups for journalists > expert reaction to study in rodent cells looking at how the GLP-1 peptide might impact measures of heart vessel damage
A rodent-cell study appearing in Nature Communications examines GLP-1 peptides alongside damage to heart vessels. Prof Bryan Williams, Chief Scientific and Medical Officer, BHF (British Heart Foundation), said: “A key goal when treating a heart attack is to bring blood flow back to the heart muscle—not only by clearing the large arteries that feed the heart, but also by re-establishing flow through the smaller microvessels that serve the heart muscle.
“According to this research, copying the action of the GLP‑1 hormone might hold potential for enhancing blood flow through microvessels and could perhaps someday play a part in treating heart attacks. Before that, thorough human studies and clinical trials would be needed.
“Big clinical trials of GLP‑1 medicines, including Ozempic and Wegovy, have demonstrated heart-health advantages that go past weight loss. Yet the way these effects come about has stayed unclear. This fascinating study puts forward one possible explanation: that these medicines may assist in improving blood flow through the heart’s smallest blood vessels.”
‘GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection’ by Svetlana Mastitskaya et al. was published in Nature Communications at 00:01 UK time on Tuesday 3 March 2026.
DOI: 10.1038/s41467-026-69555-1
Declared interests
No declaration received for Prof Bryan Williams specifically.
For the BHF: “Dr Svetlana Mastitskaya has a BHF Research Fellowship, which helped to support this study. David Attwell (senior author) is Director of the BHF-UK DRI Centre for Vascular Dementia Research.”
lessthanhalf
Explorer
From angiography I know I have non occlusive coronary artery disease, plus a very high coronary calcium score, though luckily no bypasses. I take reta 5mg alongside tirz 15mg. My own estimate: whatever extra risk comes from a high dose or a GLP combo is smaller than the risk of putting back the 80 kg I have shed.
For people with established cardiovascular disease, both semaglutide and tirzepatide have demonstrated better outcomes, including lower odds of death, heart attack and stroke; the heart failure evidence is weaker, though certain measures do improve.
That kind of data does not exist for reta yet. On top of that, it raises heart rate more than the other GLP's do.
Were there a history of arrythmias, I would steer clear of reta. At this stage tirz is the safer pick over reta: it has not been ruled out that the heart rate increase causes problems, and tirz carries proven heart disease benefits while reta carries none. In a few years reta will quite possibly have that same evidence, but it may also turn out to make arrythmias more likely.
Whether someone with bypass surgery has occlusive disease depends mostly on how long ago the operation happened. If it was recent, the possible added risks of reta are probably small; if it was a decade ago, those added risks could matter more. Either way, unless there is a strong reason to pick reta, tirz is safer.
For people with established cardiovascular disease, both semaglutide and tirzepatide have demonstrated better outcomes, including lower odds of death, heart attack and stroke; the heart failure evidence is weaker, though certain measures do improve.
That kind of data does not exist for reta yet. On top of that, it raises heart rate more than the other GLP's do.
Were there a history of arrythmias, I would steer clear of reta. At this stage tirz is the safer pick over reta: it has not been ruled out that the heart rate increase causes problems, and tirz carries proven heart disease benefits while reta carries none. In a few years reta will quite possibly have that same evidence, but it may also turn out to make arrythmias more likely.
Whether someone with bypass surgery has occlusive disease depends mostly on how long ago the operation happened. If it was recent, the possible added risks of reta are probably small; if it was a decade ago, those added risks could matter more. Either way, unless there is a strong reason to pick reta, tirz is safer.
randompersonrandom
Explorer
Looked up retatrutide (since "GLP-3" isn't actually a thing)
honestly, those Easter chicken embryos are great and all, but sometimes it feels exactly like attempting to be heard during a rubber chicken brawl.