Reconstituting Eloralintide - normal BAC water or GAC water?

kugelblitz

kugelblitz

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I'm seeing some conflicting information online. There are claims that amylin receptor agonists like Eloralintide and Cagrilintide are sensitive to the pH of the reconstituting solution and will clump. There are also claims that this only applies to Cagrilintide and that Lilly engineered Eloralintide to withstand the pH level of standard bacteriostatic water.

Can anyone clarify this for me?

And if indeed special solution is needed, what should I look for and how to identify the correct water?
 
kugelblitz said:


I'm seeing some conflicting information online. There are claims that amylin receptor agonists like Eloralintide and Cagrilintide are sensitive to the pH of the reconstituting solution and will clump. There are also claims that this only applies to Cagrilintide and that Lilly engineered Eloralintide to withstand the pH level of standard bacteriostatic water.

Can anyone clarify this for me?

And if indeed special solution is needed, what should I look for and how to identify the correct water?

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Basically, the pH concern with Cagrilintide seems legit. But that does not automatically mean Eloralintide has the same issue, especially since Eloralintide has been studied in a much higher-pH formulation.

I also would not assume regular bac water is automatically the right choice either. Without the exact formulation and compatibility data, picking a “special water” based on pH alone is still mostly guesswork.

That said, anecdotally, so far no one seems to be complaining. 🙂
 
I have been using Cagrilintide for many months now always reconstituting with bac water(Hosperia) and have never had any issue. Always clear and never any clumping.
 
kugelblitz said:


I'm seeing some conflicting information online. There are claims that amylin receptor agonists like Eloralintide and Cagrilintide are sensitive to the pH of the reconstituting solution and will clump. There are also claims that this only applies to Cagrilintide and that Lilly engineered Eloralintide to withstand the pH level of standard bacteriostatic water.

Can anyone clarify this for me?

And if indeed special solution is needed, what should I look for and how to identify the correct water?

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Click to expand...

Cagrilintide is optimally stored in solutions at pH 4, while eloralintide is optimally stored at pH 8, so these two peptides sit at virtually opposite ends of the pH spectrum.

It's important to keep in mind that these pH levels represent ideals for long-term storage stability under various conditions, not hard cutoffs for short-term use. Lilly's formulation scientists almost certainly arrived at pH 8 for eloralintide the same way Novo Nordisk arrived at pH 4 for cagrilintide: by systematically testing a range of pH levels to identify the conditions that best minimize degradation, aggregation, and loss of potency over time.

The claim that Lilly specifically engineered eloralintide to tolerate bacteriostatic water doesn't hold up. No pharmaceutical company designs a drug around the reconstitution habits of the research peptide community. pH optimization is about commercial shelf life and clinical stability.

That said, BAC water is genuinely suboptimal for both peptides. For cagrilintide it's too alkaline and too acidic for eloralintide. In practice, however, most people in this community are reconstituting both with standard BAC water and moving on, and for weekly dosing with relatively short post-reconstitution windows, the real-world impact is probably modest, though not zero. Some people are also dealing with the issue by using bac from India which has been reliably testing at about 8pH.
 
Grogu said:


Some people are also dealing with the issue by using bac from India which has been reliably testing at about 8pH.

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Which brand is this?

Is it viable to try to get my hands on pH 8 solution or should I just accept the suboptimal BAC water?

Thank you for all that context, it helps.
 
kugelblitz said:


Which brand is this?

Is it viable to try to get my hands on pH 8 solution or should I just accept the suboptimal BAC water?

Thank you for all that context, it helps.

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Genetek's bac water is testing with pH at 8, but I have no personal experience nor can I vouch for that. Just what I'm seeing. I saw a GB for Genetek bac one day this week, but don't remember where.

I've been reconstituting cagrilintide with regular bac, but just keeping it for a short amount of time, like 4 weeks from first puncture. I definitely would be conservative with eloralintide for anyone reconstituting with regular bac, I believe that it wouldn't be the time to push how long the reconstituted peptide is stored.

If you want to try to adjust the pH yourself, I'd recommend caution and avoid sodium based buffers. Someone said that to me earlier this year, even before elora was available, but it has something to do with ions and the fact that elora is pretty complex.
 
Grogu said:


Genetek's bac water is testing with pH at 8, but I have no personal experience nor can I vouch for that. Just what I'm seeing. I saw a GB for Genetek bac one day this week, but don't remember where.

I've been reconstituting cagrilintide with regular bac, but just keeping it for a short amount of time, like 4 weeks from first puncture. I definitely would be conservative with eloralintide for anyone reconstituting with regular bac, I believe that it wouldn't be the time to push how long the reconstituted peptide is stored.

If you want to try to adjust the pH yourself, I'd recommend caution and avoid sodium based buffers. Someone said that to me earlier this year, even before elora was available, but it has something to do with ions and the fact that elora is pretty complex.

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Oh, that's excellent. I've been toying with getting a bunch of Gentek, as it is cheaper and easier to get within EU than Hospira, so that works out nicely. Thanks.
 
Grogu said:


Genetek's bac water is testing with pH at 8, but I have no personal experience nor can I vouch for that. Just what I'm seeing. I saw a GB for Genetek bac one day this week, but don't remember where.

I've been reconstituting cagrilintide with regular bac, but just keeping it for a short amount of time, like 4 weeks from first puncture. I definitely would be conservative with eloralintide for anyone reconstituting with regular bac, I believe that it wouldn't be the time to push how long the reconstituted peptide is stored.

If you want to try to adjust the pH yourself, I'd recommend caution and avoid sodium based buffers. Someone said that to me earlier this year, even before elora was available, but it has something to do with ions and the fact that elora is pretty complex.

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Thanks for this info! My Genetek should be arriving before my Elora...yee-haw!! And it's good to know re: it's pH so I can keep it away from my more acid-loving peptides.
 
HouseCat said:


Thanks for this info! My Genetek should be arriving before my Elora...yee-haw!! And it's good to know re: it's pH so I can keep it away from my more acid-loving peptides.

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Are you going to test the pH? If so, it would be great if you could post the results here. I think it could be done with some relatively inexpensive test strips.
 
Grogu said:


Genetek's bac water is testing with pH at 8, but I have no personal experience nor can I vouch for that. Just what I'm seeing. I saw a GB for Genetek bac one day this week, but don't remember where.

I've been reconstituting cagrilintide with regular bac, but just keeping it for a short amount of time, like 4 weeks from first puncture. I definitely would be conservative with eloralintide for anyone reconstituting with regular bac, I believe that it wouldn't be the time to push how long the reconstituted peptide is stored.

If you want to try to adjust the pH yourself, I'd recommend caution and avoid sodium based buffers. Someone said that to me earlier this year, even before elora was available, but it has something to do with ions and the fact that elora is pretty complex.

Click to expand...
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My box of Genetek BAC water 10ml ampoules are testing at 5.5-6 pH. I saw one COA with a 7.9 pH but have you seen others? Also, Genetek reconned Reta perfectly and crystal clear weeks later, not indicative of a high pH BAC.

Just my anecdotal results.
 
Grogu said:


Are you going to test the pH? If so, it would be great if you could post the results here. I think it could be done with some relatively inexpensive test strips.

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Sure thing! I have a bunch pH test strips I haven't yet used since I'm still just using Hospira and am not yet on any finicky-pH peptides.
 
WeezinDaJuice said:


My box of Genetek BAC water 10ml ampoules are testing at 5.5-6 pH. I saw one COA with a 7.9 pH but have you seen others? Also, Genetek reconned Reta perfectly and crystal clear weeks later, not indicative of a high pH BAC.

Just my anecdotal results.

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Yes, I saw that COA, but haven't seen others, which is why I recommended that @HouseCat check the pH of their Genetek bac water. And had a general disclaimer that I have no personal experience with Genetek's pH. I'd also be concerned (if the pH is actually 8) how Genetek accomplished that and what agents they used.
 
kugelblitz said:


I'm seeing some conflicting information online. There are claims that amylin receptor agonists like Eloralintide and Cagrilintide are sensitive to the pH of the reconstituting solution and will clump. There are also claims that this only applies to Cagrilintide and that Lilly engineered Eloralintide to withstand the pH level of standard bacteriostatic water.

Can anyone clarify this for me?

And if indeed special solution is needed, what should I look for and how to identify the correct water?

Click to expand...
Click to expand...
Just give it a try with good quality bac like Hosperia. Like many have mentioned here, no problems with straight bac water.
 
Grogu said:


Yes, I saw that COA, but haven't seen others, which is why I recommended that @HouseCat check the pH of their Genetek bac water. And had a general disclaimer that I have no personal experience with Genetek's pH. I'd also be concerned (if the pH is actually 8) how Genetek accomplished that and what agents they used.

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I posted in a prior thread, a pic of the PH strips. I believe it came around 5.5-6
 
gusterbuster said:


I posted in a prior thread, a pic of the PH strips. I believe it came around 5.5-6

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Thank you! Didn't remember the thread. If anyone is looking, here it is:




Bac water



Almost half of the generic drugs in US come from India. So its not like this is some underground lab BAC water. We all have our own risk tolerance. I personally feel safe with genetek bac water. Shit I used vendor bac water for first few months with no issues until hospira cult scared me...

051f0e2f5b7f6ffbb4a2f10b404546ba44b6197464dfbacec1b043fb189c69a3.png



GLP1Chat.com

If I buy any Genetek, hoping that it has higher pH, I won't buy much. Maybe this higher pH bac water is an urban legend. 😂
 
Crypto said:


Just give it a try with good quality bac like Hosperia. Like many have mentioned here, no problems with straight bac water.

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This is what most people are doing. I would only add that I would reconstitute both cagri and elora with plenty of good quality bac. This is not the time to be stingy with the bac water. And also to be gentle during the filtering process and go slowly. I only say this from experience, because I had to trash a vial because I created some bubbles/film that wouldn't dissipate. Not sure if it was the concentration or the quick filtering. I'm thinking the later.
 
chewonmysac said:


BAC worked fine. Just reconstituted second vial.

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What’s the protocol for eloralintide please, like what’s the starting dose and when in a week should it be used? Thank you!
 
This is not medical advice. I did the following.

First week 1mg two days before weekly Tirz shot. This stack was used to bridge the gap. Tirz starts to wear off on day 5ish for most on a 7 day schedule. After 4 weeks moved up to 2mg weekly same time. Worked fantastic with slight tiredness when titration up to 2mg. That has now subsided. The half life is 12-14 days so compounded by weekly dose is something to pay attention to. Not too shabby for the first batch from Uther. I was impressed.
 
Do anyone know how long reconstituted elora holds in the fridge? A 10mg vial will take quite a long time to empty on a low starting dose.

I'm starting on Thursday as I took my tirz today. I thought that it would be a good schedule with

Thursdays Elora

Sundays tirz

I'm on 7,5mg tirz and haven't decided on my start dose of Elora. 0,5 or 1 mg. Thoughts?
 
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