Peptides for recurring or chronic infections?

[beforetherush]

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

 

[RubbaDubba1]

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

 

[lessthanhalf]

Since KPV belongs to the class of innate antimicrobial peptides, it does possess certain antibacterial activity. The catch, naturally, is that every bit of the research exists only in cell cultures or mice, with nothing at all in humans, and the majority of those studies do not even focus on antibacterial action. In most of the rodent work, the doses given were far above what anyone can actually obtain, meaning that matching human-equivalent dosing would run into enormous expense. I did dig into this, because there is a decent amount of material on how it performs in ulcerative colitis ( which I have ), or at least the mouse-model version of that research, yet several obstacles stood in the way: no human trials exist, oral administration would cause it to break down before reaching the intended site in the gut, and the cost per dose is prohibitive. Antibiotics, by contrast, are neither scarce nor hard to source, and there are hundreds of them, every one backed by stronger proof that they combat real infections in people than any peptide can offer.

As for how the remaining peptides might influence immune function, I am not in a position to say much, since I have not read extensively on that subject.

 

[Jfrick11]

I've combined Thymalin with Thymosin Alpha-1.

 

[Chili777]

I brought a sinus infection on myself — whether from skipping filtration on my peptides, or from 60 days in a row of IN alongside a long list of nasal sprays. Looking back, either one was equally foolish. I've been running KPV (500 mcg per day) and I'm now in month 2. A few months back I also picked up some TA-1, intending to research it eventually, but last Wednesday I broke it open to research it as a line of defense. So far, my response has honestly stunned me. I'm researching 1.6 mg per day, which is what's recommended during an acute infection phase. Apart from Astepro for congestion, nothing else has been in the mix.

I won't call it a win just yet, but each day feels like progress. If things keep going this way, TA-1 stays in my tool kit for good. By now I'd usually be on the phone trying to book an appointment for antibiotics. Getting around that — and the microbiome disruption that comes with it — would be a genuine win.

 

[beforetherush]

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

 

[RubbaDubba1]

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Seems like there may be a more fundamental issue at play for you. Besides TA1, it could be worth exploring LL37 too. A search on this site turned up almost nothing about it, though I did find these few points.

LL-37 is a human cathelicidin, part of the wider antimicrobial peptides (AMPs) family. Certain white blood cells—macrophages and neutrophils among them—are the main producers, and it comes up in discussions of innate and adaptive immunity, drawing research interest as a possible non-antibiotic option.

Deeper Research Notes (Summary):

• LL-37 gets described as an antimicrobial protein made by immune cells that combats bacteria and helps modulate inflammation—in part through contact with bacterial cell walls and membrane disruption (pore formation), which can result in bacterial death.

• Even though higher LL-37 levels are frequently observed in inflammatory conditions, some research discussion positions LL-37 as possibly protective against overactive immune responses; in different settings it might boost or calm immune activity to keep things balanced.

• LL-37 is talked about as aiding tissue repair in the lungs and intestines by drawing epithelial cells toward wound sites, encouraging new blood vessel growth (for nutrient delivery), and helping modulate inflammation—commonly referenced in asthma and inflammatory bowel disease models.

• LL-37 also comes up for a possible immune-support function in cancer settings, especially in the gastrointestinal tract, by assisting immune surveillance in recognizing and clearing abnormal cells.

After reading about it, I may pick some up to have on hand for a viral infection. Spending someone else's money is easy, but this could be a situation where a Functional Medicine Dr. could assist. It can easily run into the thousands, I realize. I still do telehealth with a Dr. every few months myself—to get a few things and pick his brain—but I can't keep affording it much longer.

 

[beforetherush]

RubbaDubba1 said:

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Seems like there may be a more fundamental issue at play for you. Besides TA1, it could be worth exploring LL37 too. A search on this site turned up almost nothing about it, though I did find these few points.

LL-37 is a human cathelicidin, part of the wider antimicrobial peptides (AMPs) family. Certain white blood cells—macrophages and neutrophils among them—are the main producers, and it comes up in discussions of innate and adaptive immunity, drawing research interest as a possible non-antibiotic option.

Deeper Research Notes (Summary):

• LL-37 gets described as an antimicrobial protein made by immune cells that combats bacteria and helps modulate inflammation—in part through contact with bacterial cell walls and membrane disruption (pore formation), which can result in bacterial death.

• Even though higher LL-37 levels are frequently observed in inflammatory conditions, some research discussion positions LL-37 as possibly protective against overactive immune responses; in different settings it might boost or calm immune activity to keep things balanced.

• LL-37 is talked about as aiding tissue repair in the lungs and intestines by drawing epithelial cells toward wound sites, encouraging new blood vessel growth (for nutrient delivery), and helping modulate inflammation—commonly referenced in asthma and inflammatory bowel disease models.

• LL-37 also comes up for a possible immune-support function in cancer settings, especially in the gastrointestinal tract, by assisting immune surveillance in recognizing and clearing abnormal cells.

After reading about it, I may pick some up to have on hand for a viral infection. Spending someone else's money is easy, but this could be a situation where a Functional Medicine Dr. could assist. It can easily run into the thousands, I realize. I still do telehealth with a Dr. every few months myself—to get a few things and pick his brain—but I can't keep affording it much longer.

Thanks, this is really helpful — I'll check into that along with TA1!

 

[Chili777]

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

 

[Jack brown]

RubbaDubba1 said:

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Seems like there may be a more fundamental issue at play for you. Besides TA1, it could be worth exploring LL37 too. A search on this site turned up almost nothing about it, though I did find these few points.

LL-37 is a human cathelicidin, part of the wider antimicrobial peptides (AMPs) family. Certain white blood cells—macrophages and neutrophils among them—are the main producers, and it comes up in discussions of innate and adaptive immunity, drawing research interest as a possible non-antibiotic option.

Deeper Research Notes (Summary):

• LL-37 gets described as an antimicrobial protein made by immune cells that combats bacteria and helps modulate inflammation—in part through contact with bacterial cell walls and membrane disruption (pore formation), which can result in bacterial death.

• Even though higher LL-37 levels are frequently observed in inflammatory conditions, some research discussion positions LL-37 as possibly protective against overactive immune responses; in different settings it might boost or calm immune activity to keep things balanced.

• LL-37 is talked about as aiding tissue repair in the lungs and intestines by drawing epithelial cells toward wound sites, encouraging new blood vessel growth (for nutrient delivery), and helping modulate inflammation—commonly referenced in asthma and inflammatory bowel disease models.

• LL-37 also comes up for a possible immune-support function in cancer settings, especially in the gastrointestinal tract, by assisting immune surveillance in recognizing and clearing abnormal cells.

After reading about it, I may pick some up to have on hand for a viral infection. Spending someone else's money is easy, but this could be a situation where a Functional Medicine Dr. could assist. It can easily run into the thousands, I realize. I still do telehealth with a Dr. every few months myself—to get a few things and pick his brain—but I can't keep affording it much longer.

If it were me, LL37 wouldn't be on the list: https://pubmed.ncbi.nlm.nih.gov/36138130/

LL-37, a human antimicrobial peptide, plays a part in Alzheimer's disease progression#-human-antimicrobial-peptide-ll-37-contributes-to-alzheimers-disease-progression

 

[RubbaDubba1]

Jack brown said:

RubbaDubba1 said:

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Seems like there may be a more fundamental issue at play for you. Besides TA1, it could be worth exploring LL37 too. A search on this site turned up almost nothing about it, though I did find these few points.

LL-37 is a human cathelicidin, part of the wider antimicrobial peptides (AMPs) family. Certain white blood cells—macrophages and neutrophils among them—are the main producers, and it comes up in discussions of innate and adaptive immunity, drawing research interest as a possible non-antibiotic option.

Deeper Research Notes (Summary):

• LL-37 gets described as an antimicrobial protein made by immune cells that combats bacteria and helps modulate inflammation—in part through contact with bacterial cell walls and membrane disruption (pore formation), which can result in bacterial death.

• Even though higher LL-37 levels are frequently observed in inflammatory conditions, some research discussion positions LL-37 as possibly protective against overactive immune responses; in different settings it might boost or calm immune activity to keep things balanced.

• LL-37 is talked about as aiding tissue repair in the lungs and intestines by drawing epithelial cells toward wound sites, encouraging new blood vessel growth (for nutrient delivery), and helping modulate inflammation—commonly referenced in asthma and inflammatory bowel disease models.

• LL-37 also comes up for a possible immune-support function in cancer settings, especially in the gastrointestinal tract, by assisting immune surveillance in recognizing and clearing abnormal cells.

After reading about it, I may pick some up to have on hand for a viral infection. Spending someone else's money is easy, but this could be a situation where a Functional Medicine Dr. could assist. It can easily run into the thousands, I realize. I still do telehealth with a Dr. every few months myself—to get a few things and pick his brain—but I can't keep affording it much longer.

If it were me, LL37 wouldn't be on the list: https://pubmed.ncbi.nlm.nih.gov/36138130/

LL-37, a human antimicrobial peptide, plays a part in Alzheimer's disease progression#-human-antimicrobial-peptide-ll-37-contributes-to-alzheimers-disease-progression

That's helpful to know. I haven't tried it personally, though I do have some on hand. Certainly worth considering—thanks.

 

[Crumplestiltskin]

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Dealing with a chronic sinus infection is truly miserable — I feel for you. I've experienced them too, and a few approaches made a difference for me:

Intranasal ozone (it can be tricky to source, but it's worth seeking out); I used it 2 times a day over the course of a few weeks. Within 1 or 2 days I noticed improvement, though I kept going to ensure it fully cleared.

Sinus probiotics, particularly L.sakai — available for purchase online; I combine it with a small number of drops of distilled water and put it straight into the nose. Certain studies indicated that people with chronic sinus infections had insufficient amounts of that particular probiotic, so giving it a try seems worthwhile.

 

[Chili777]

Appreciate it. Around 2019 I had the balloon procedure done to widen the sinuses, and until this current bout, I hadn't had a serious infection since — so that's a positive. Before the procedure, I was getting hit 2 or 3 times annually, which was miserable. Following the directions, I used a Nettie bottle with an extra ampule of budesinide, but it didn't help. The TA-1 probably did some good. Things are improving now, and I'm nearly ready to put more peptides up my nose!

For anyone dealing with chronic sinusitis, I strongly suggest looking into Balloon Sinuplasty. It was a game changer for me, and it was performed right in the office. The whole thing lasted 30 min from beginning to end.

More recently, I came across mention of a TA-1 and KPV nasal spray that supposedly lessens or wipes out allergy symptoms. I might try making my own. There's a vendor offering one at a 50/50 concentration, though whether that ratio is ideal I can't say, so I'll keep looking into it. https://ultralifepeptides.com/shop/ta-1-kpv-10-mg-10-mg-n/

 

[Peptidesearch]

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Honestly, I'm skeptical that any peptide would make a difference here — particularly when as many as 10% don't even pass sterility testing. Has an infectious disease specialist weighed in on your situation?

 

[beforetherush]

Peptidesearch said:

beforetherush said:

RubbaDubba1 said:

beforetherush said:

Is there anyone here who has run a protocol combining Thymosin Alpha 1 with KPV to deal with an infection that keeps coming back or has become chronic? In my case, a lab rat has been dealing with this situation and seems to develop the same infection annually, to the point where surgery is needed. I'm just wondering whether anybody has given something like this a try.

For 2 winters now I've been taking TA-1, and during both I never even got a runny nose. A while back I picked up my 1st full kit, and I'm currently dosing 1mg daily—started that in the last couple weeks following my surgery. My white blood cell count runs pretty low, and I've got another operation coming up soon. From what I've read, TA1 might be able to boost your WBC and help bring your immune system into balance. For me this is going to be the Litmus test—whether my WBC can go up by a decent amount. At the moment I'm doing a KLOW protocol; I haven't used KPV on its own. I realize this is just anecdotal, and I wish I could give you something more solid.

Not to pry, but is the infection located where you had a joint replacement or had metal implanted? I ask only because I've been through several operations—knees, ankle, weight loss surgery—and before dental appointments I take an Antibiotic to avoid infection in the areas where I have metal in my body.

I received a cortisone injection to address knee pain. Since then, an infection has come back annually — occasionally 2-3 times within a single year. It shows up in various parts of the body. I've gone through surgical procedures, IV courses packed with anti-biotics, and additional approaches. Yet each year, without fail, another reoccurring infection appears.

Honestly, I'm skeptical that any peptide would make a difference here — particularly when as many as 10% don't even pass sterility testing. Has an infectious disease specialist weighed in on your situation?

Yes, this issue has been addressed for years. It keeps returning.

 

[janedoe]

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Roughly the past 5 years, out of nowhere, I've been getting severe sinus infections... bleeding, green discharge.... it's been intense. Headaches, eye strain, brain fog, and darkening around the eye (KPV did help with that part) among other things. About 2 years ago I had one that eventually resolved after 2 rounds of augmentin, spaced apart. Prescription spray is useless. These days I keep an Augmentin prescription stocked.

But starting in January, I've had an infection, and KPV hasn't done anything for it. I was really hoping it would, since KPV works so well for me in other ways. I really wish

LL-37 didn't come with the AD concerns, because setting that aside, it seems like it could be beneficial.

 

[Chili777]

janedoe said:

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Roughly the past 5 years, out of nowhere, I've been getting severe sinus infections... bleeding, green discharge.... it's been intense. Headaches, eye strain, brain fog, and darkening around the eye (KPV did help with that part) among other things. About 2 years ago I had one that eventually resolved after 2 rounds of augmentin, spaced apart. Prescription spray is useless. These days I keep an Augmentin prescription stocked.

But starting in January, I've had an infection, and KPV hasn't done anything for it. I was really hoping it would, since KPV works so well for me in other ways. I really wish

LL-37 didn't come with the AD concerns, because setting that aside, it seems like it could be beneficial.

Has an ENT been consulted in your case? After dealing with several of these annually for a while, the balloon sinuplasty was the thing that ended them for me. The one I got was the first since 2019. I cycled through 8 or 9 antibiotics, and the options were running thin, which is a scary spot to be in. It was only after 3 weeks on Augmentin that I finally requested the sinuplasty from my doctor. As it happened, getting it done the moment it became an option would have been the right call. With that plus Astepro to keep my nasal passages clear, I've managed to keep them at bay. I hope you and they get it sorted out, for your sake.

 

[janedoe]

Chili777 said:

janedoe said:

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Roughly the past 5 years, out of nowhere, I've been getting severe sinus infections... bleeding, green discharge.... it's been intense. Headaches, eye strain, brain fog, and darkening around the eye (KPV did help with that part) among other things. About 2 years ago I had one that eventually resolved after 2 rounds of augmentin, spaced apart. Prescription spray is useless. These days I keep an Augmentin prescription stocked.

But starting in January, I've had an infection, and KPV hasn't done anything for it. I was really hoping it would, since KPV works so well for me in other ways. I really wish

LL-37 didn't come with the AD concerns, because setting that aside, it seems like it could be beneficial.

Has an ENT been consulted in your case? After dealing with several of these annually for a while, the balloon sinuplasty was the thing that ended them for me. The one I got was the first since 2019. I cycled through 8 or 9 antibiotics, and the options were running thin, which is a scary spot to be in. It was only after 3 weeks on Augmentin that I finally requested the sinuplasty from my doctor. As it happened, getting it done the moment it became an option would have been the right call. With that plus Astepro to keep my nasal passages clear, I've managed to keep them at bay. I hope you and they get it sorted out, for your sake.

Yes, I did see one. The 2 rounds of Augmentin were prescribed by him, along with a nasal spray prescription for Ipratropium Bromide. After pushing a scope into my nasal cavity, he told me there was a deviation. Surgery was never brought up by him. I do remember that at first he was leaning toward giving me Doxy, but I told him I preferred the Augmentin. I might ask about the surgical procedure. This has really worn me down. I'm hoping for some relief as well. Thanks for sharing that.

 

[Crumplestiltskin]

janedoe said:

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Roughly the past 5 years, out of nowhere, I've been getting severe sinus infections... bleeding, green discharge.... it's been intense. Headaches, eye strain, brain fog, and darkening around the eye (KPV did help with that part) among other things. About 2 years ago I had one that eventually resolved after 2 rounds of augmentin, spaced apart. Prescription spray is useless. These days I keep an Augmentin prescription stocked.

But starting in January, I've had an infection, and KPV hasn't done anything for it. I was really hoping it would, since KPV works so well for me in other ways. I really wish

LL-37 didn't come with the AD concerns, because setting that aside, it seems like it could be beneficial.

That sounds really rough, I'm sorry you're dealing with it. One possibility worth checking is a low-grade dental infection. A 3D cone beam scan can be quite useful for spotting infections, particularly if you've had oral surgery before, such as wisdom teeth extraction or root canals.

 

[janedoe]

Crumplestiltskin said:

janedoe said:

Chili777 said:

So my TA-1 and KPV trial for a sinus infection didn't work out. I went 8 days without any improvement, and finally had to give in and get an Augmentin prescription today. I'll keep taking TA-1 every day to finish what I mixed up, and I'll complete my 60-day KPV run too. I realize it's boosting my immune system, but expecting it to clear a serious sinus infection was probably too much.

Roughly the past 5 years, out of nowhere, I've been getting severe sinus infections... bleeding, green discharge.... it's been intense. Headaches, eye strain, brain fog, and darkening around the eye (KPV did help with that part) among other things. About 2 years ago I had one that eventually resolved after 2 rounds of augmentin, spaced apart. Prescription spray is useless. These days I keep an Augmentin prescription stocked.

But starting in January, I've had an infection, and KPV hasn't done anything for it. I was really hoping it would, since KPV works so well for me in other ways. I really wish

LL-37 didn't come with the AD concerns, because setting that aside, it seems like it could be beneficial.

That sounds really rough, I'm sorry you're dealing with it. One possibility worth checking is a low-grade dental infection. A 3D cone beam scan can be quite useful for spotting infections, particularly if you've had oral surgery before, such as wisdom teeth extraction or root canals.

Wow, that is so accurate! I've lived it myself! About 2 years back, I came down with one of those awful sinus infections, and my ENT put me through 2 rounds of Augmentin, and so on. I go to the dentist 2x a year, my teeth are in great shape, and I keep up good dental hygiene. In 12 years I've only had 1 cavity. Anyway, when I had my x-rays taken 2 years ago (right after those ENT appointments), my dentist "saw a shadow" high up on the right side, above my cheek, but nothing dental showed up. No pain, no swelling, nothing. He was aware of my sinus trouble, and even though he isn't keen on root canals, he recommended one, saying it sat right beside the upper sinus cavity and might bring me relief. He made it very clear he couldn't tell me whether the sinus infection was the cause or whether the root of my eyetooth was actually the source of the infection. (The chicken/egg problem.) Either way, though, he was clear that both scenarios would create problems in both directions.

I had the root canal, and within a few weeks I was fine. It was amazing. Almost 2 years with no issues. I see him 2x a year and everything stayed good. But since January, it's back, and it's crazy. My 6 month dental appointment is coming up. I can't wait to go!