Peptide for muscle relaxation

[Slaine]

Does anyone know of a peptide that can ease or eliminate muscle spasms? During the acute phase, nothing provides relief (medication, physical therapy, massage, acupuncture, even large doses of magnesium, etc.). I looked around and came up empty.

Azemiopsin looks like it could be worth exploring, though I haven't been able to locate much information on it. Botox-type agents act through a different mechanism, and that route doesn't interest me.

Anyone have ideas?

Thanks!

P.S.: Clearly the spasm stems from something else, such as autoimmunity, inflammation, an injury, an agonist/antagonist imbalance, a poor diet, and so on. I realize that addressing the root cause matters more, but the doctors still haven't reached a conclusion, and when it flares up badly I need something that acts quickly.

 

[trey915]

I'm not aware of any peptides that work as muscle relaxants. That said, if inflammation is what's driving the problem, wouldn't it make more sense to go after the cause? That's the part I appreciate about peptides: rather than masking the cause and only managing symptoms, they can actually address the root of it and get rid of the symptoms.

 

[RubbaDubba1]

Slaine said:


Is there any peptide that relaxes/solves muscle spasms? In the acute phase nothing helps (medicine, pt, massage, acupuncture, huge doses of magnesium etc). I did a search and couldn't find anything.

Azemiopsin might be promising but haven't managed to find a lot of info. Botox-like substances work differently and I am not interested in that.

Any suggestions?

Thank you!

Ps: obviously the spasm is a result of something else ie autoimmune, inflammation, injury, imbalance between agonists/antagonists, poor diet etc. Trying to solve the cause is more important, I understand, but still the doctors haven't concluded and also when it hits hard I need something that works fast.

Click to expand...

This may be an unusual case, and it's still too soon to say for sure. For a number of years I've had to deal with spasms, and until not long ago I was getting 40-50 neck spasms every day. I was able to suppress them by taking enough Tizanidine, but then I couldn't take any of my other medications if I wanted to remain on my feet.

3 weeks ago I received some (PRP) Platelet Rich Plasma injections in my neck, covering my C2-T1. My occipitals were given a nerve hydrodissection for my hedaches, and 7 trigger points were treated too. Everything was treated using my own blood, no drugs involved. At this point my neck spasms have dropped to 1-2 per day, and they're less severe as well. This is likely further than most people would go, but I had run out of everything regular medicine would cover and a lot of what I paid for myself. Looking forward to doing the back, if this holds up and hopefully improves.

Where peptides are concerned, the only one I can think of, and the one I tried, is topical: SNAP-8. If you search, you can find some threads about it here. I mixed some into a facial cream and it produced a very mild relaxing effect and reduced the tightness of my skin, which eased my heaches a little. The only other one I came across is SYN-AKE, and I suppose it might work better for this kind of thing, but it's topical, and maybe you'd mix it with some body lotion or seomething?

 

[Slaine]

RubbaDubba1 said:

This may be an unusual case, and it's still too soon to say for sure. For a number of years I've had to deal with spasms, and until not long ago I was getting 40-50 neck spasms every day. I was able to suppress them by taking enough Tizanidine, but then I couldn't take any of my other medications if I wanted to remain on my feet.

3 weeks ago I received some (PRP) Platelet Rich Plasma injections in my neck, covering my C2-T1. My occipitals were given a nerve hydrodissection for my hedaches, and 7 trigger points were treated too. Everything was treated using my own blood, no drugs involved. At this point my neck spasms have dropped to 1-2 per day, and they're less severe as well. This is likely further than most people would go, but I had run out of everything regular medicine would cover and a lot of what I paid for myself. Looking forward to doing the back, if this holds up and hopefully improves.

Where peptides are concerned, the only one I can think of, and the one I tried, is topical: SNAP-8. If you search, you can find some threads about it here. I mixed some into a facial cream and it produced a very mild relaxing effect and reduced the tightness of my skin, which eased my heaches a little. The only other one I came across is SYN-AKE, and I suppose it might work better for this kind of thing, but it's topical, and maybe you'd mix it with some body lotion or seomething?

I appreciate your reply!

 

[Slaine]

trey915 said:

I'm not aware of any peptides that work as muscle relaxants. That said, if inflammation is what's driving the problem, wouldn't it make more sense to go after the cause? That's the part I appreciate about peptides: rather than masking the cause and only managing symptoms, they can actually address the root of it and get rid of the symptoms.

Thanks. I suppose the cause of the inflammation makes a difference.

 

[lessthanhalf]

Medically speaking, muscle spasms can be treated quite effectively. Benzodiazepines like diazepam (Valium) tend to work well, and there are plenty of other muscle-relaxing medications besides those. The trouble is that the majority of them cause some sedation and carry addiction potential, which is why doctors have largely moved away from prescribing benzodiazepines. Still, when spasms are bad enough that daily life or quality of life takes a serious hit, looking at those options seems fair. And if the spasms themselves are the primary source of the pain, addressing the spasms makes more sense than reaching for potent painkillers.

Should significant chronic pain be an issue and your current medical therapists do not appear to be offering much help, a referral to a pain management specialist could be worth pursuing. Chronic pain is frequently untreated or undertreated by doctors, at times because good, safe, non-addicting choices are scarce, and pain can be something of a medical blind spot, yet there is no genuine excuse for failing to try.

From what I understand, no peptide is likely to lessen muscle spasms. Both India and China are highly reluctant to supply sedative or analgesic drugs or peptides, since they want to avoid legal problems. The single exception is desmorphin, an ultra potent opioid painkilling peptide with a very short duration of action, which sounds extraordinarily dangerous when it comes to overdose or addiction risk. That is the one peptide I believe should not be sold, given that its extremely short half life makes it useless as a painkiller and given the dangers it carries.

 

[Slaine]

lessthanhalf said:

Medically speaking, muscle spasms can be treated quite effectively. Benzodiazepines like diazepam (Valium) tend to work well, and there are plenty of other muscle-relaxing medications besides those. The trouble is that the majority of them cause some sedation and carry addiction potential, which is why doctors have largely moved away from prescribing benzodiazepines. Still, when spasms are bad enough that daily life or quality of life takes a serious hit, looking at those options seems fair. And if the spasms themselves are the primary source of the pain, addressing the spasms makes more sense than reaching for potent painkillers.

Should significant chronic pain be an issue and your current medical therapists do not appear to be offering much help, a referral to a pain management specialist could be worth pursuing. Chronic pain is frequently untreated or undertreated by doctors, at times because good, safe, non-addicting choices are scarce, and pain can be something of a medical blind spot, yet there is no genuine excuse for failing to try.

From what I understand, no peptide is likely to lessen muscle spasms. Both India and China are highly reluctant to supply sedative or analgesic drugs or peptides, since they want to avoid legal problems. The single exception is desmorphin, an ultra potent opioid painkilling peptide with a very short duration of action, which sounds extraordinarily dangerous when it comes to overdose or addiction risk. That is the one peptide I believe should not be sold, given that its extremely short half life makes it useless as a painkiller and given the dangers it carries.

I appreciate your response!