I get mostly these five responses when someone mentions my kinda-dramatic weight loss or asks how I did it, and I throw my hands in the air and crow "MAGIC SKINNY SHOOOOOOTS, Tirzepatide is a miracle and I will never, ever, EVER stop taking it, try and pry it out of my hands NOW!"
"OMG ME TOOOOOOOO GO US!" (common)
"WOW THAT IS WONDERFUL FOR YOU I AM SO HAPPY YOU FOUND A WAY THAT WORKED (genuine)"
"Huh. I'm about to ask you eight billion questions because I am happily surprised that you were so forthcoming which makes me suspect that it's probably fine to ask you all the questions I've wanted to have answered before I decide if I want it myself." (yes, that is fine)
"Oh. I was considering saying something very southern and casually cruel and passive-aggressively snotty, but you just reminded me that you are loud and very happy and don't appear easy to shame, so it would probably take more aggression than I'm willing to casually bring to the table to actually shame you the way I'd like to, so I think I'll say something very noncommittal and let you change the subject." (not terribly common because I just don't know a lot of that kind of people, but the ones I DO know are smart enough not to try to bring that to my table.)
"I was ready to shame you and have shamed others... but the fact that you don't accept that it's shameful just made me reconsider whether I accept that it's shameful and now I have questions and may actually start myself." (I am kinda surprised how common that one is.)
Also, I saw a plastic surgeon yesterday about getting my eyes done, an old Eastern European guy. His fellow did my exam, then brought him in, and mentioned "And also, she's had a sixty pound weight loss." The surgeon lit up and said "Did you..." (and made a fist, and pushed it to his abdomen.) I laughed and said "yes! Tirzepatide!" He ALSO laughed and said "YES! TIRZEPATIDE! HOORAY FOR TIRZEPATIDE!" and we took a minute to just yell "HOORAY" while his fellow waited politely.