New member intro: prediabetes and sleep apnea reversed with tirz

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bingbong1235

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Hey all,

I've been reading for a while without posting. Peptides are still quite new to me, though I began tirz roughly 4 weeks back and am starting to notice changes. My weight has always trended high, and it kept getting worse over time. So far I'm down about 12 pounds. Recent labs came back, and after just 4 weeks of use, my prediabetes is no longer present and my triglyceride levels dropped sharply. My watch isn't giving sleep apnea alerts anymore. I've felt somewhat fatigued and anhedonic, but that has leveled out.

I also picked up some reta not long ago, so I'll add it in soon, aiming for the glucagon effects and a boost in energy. My thinking was that at a low dose it might reduce visceral and liver fat. I'm considering trimming the tirz dose slightly and continuing it for appetite control and anti-inflammatory benefits, then testing how a starter dose of reta performs alongside it.

Given how new I am to this, I've already got a fair amount stocked: 1950mg tirz and 950mg reta over 8 kits. I might hold off on buying more until I know whether I like reta. Bac water is somewhat scarce at the moment, so that could hold me back. I'm putting together a solid set of supplies and kits. Trying to cover every angle and reduce risk wherever I can. Glad to be here and to keep learning.
 
Sounds like things are working out for you....nice job!!!

I'm close to throwing in the towel. Every place I try to buy stuff from, I end up getting scammed. I'm fed up with it. After spending so much, you sort of lose hope. Still, I'm happy your experience has been so good up to now.
 
I get where you're coming from — honestly, finding what works usually takes a while and involves some trial and error. Early on, a few folks took advantage of me and I ended up getting scammed. It's something that happens, and losing money that way feels awful. There are plenty of people who target newcomers because they're desperate to get their hands on something. Don't throw in the towel just yet... there are still lots of solid, trustworthy sources around. Before you buy, give yourself time and collect as much info as you can. For your first few purchases, stay careful, and my suggestion is to begin with a low dose and go slow. Once you manage to get the right product, everything becomes worthwhile.
 
bingbong1235 said:

Peptide_J said:

Glad to be here, picked up plenty from this community
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I appreciate it! Communities like this are where you actually find useful information.
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Likely some of each, though this has served as a really useful resource for me up to now.
 
bingbong1235 said:

Hey all,

I've been reading for a while without posting. Peptides are still quite new to me, though I began tirz roughly 4 weeks back and am starting to notice changes. My weight has always trended high, and it kept getting worse over time. So far I'm down about 12 pounds. Recent labs came back, and after just 4 weeks of use, my prediabetes is no longer present and my triglyceride levels dropped sharply. My watch isn't giving sleep apnea alerts anymore. I've felt somewhat fatigued and anhedonic, but that has leveled out.

I also picked up some reta not long ago, so I'll add it in soon, aiming for the glucagon effects and a boost in energy. My thinking was that at a low dose it might reduce visceral and liver fat. I'm considering trimming the tirz dose slightly and continuing it for appetite control and anti-inflammatory benefits, then testing how a starter dose of reta performs alongside it.

Given how new I am to this, I've already got a fair amount stocked: 1950mg tirz and 950mg reta over 8 kits. I might hold off on buying more until I know whether I like reta. Bac water is somewhat scarce at the moment, so that could hold me back. I'm putting together a solid set of supplies and kits. Trying to cover every angle and reduce risk wherever I can. Glad to be here and to keep learning.
Click to expand...
I'm only at the beginning of exploring peptides. I began Tirz 3 weeks back, and once I've researched more and located a suitable supplier, I intend to move over to Reta. Best of luck with your weight loss journey. My health background and issues are much like yours. I'm hopeful that peptides will ease my problems.
 
From a research perspective, what draws attention to the visceral and liver fat angle is reta's glucagon component. The GIP/GLP-1 side is well covered by tirz, but glucagon receptor activation works differently, and the hepatic fat data in particular deserves close attention. Combining the two at lower doses each, in order to keep side effects in check while retaining the metabolic mechanisms, is a logical approach. Reversing prediabetes within 4 weeks is a strong result — labs don't lie.

Welcome .
 
Rawbiotix said:

From a research perspective, what draws attention to the visceral and liver fat angle is reta's glucagon component. The GIP/GLP-1 side is well covered by tirz, but glucagon receptor activation works differently, and the hepatic fat data in particular deserves close attention. Combining the two at lower doses each, in order to keep side effects in check while retaining the metabolic mechanisms, is a logical approach. Reversing prediabetes within 4 weeks is a strong result — labs don't lie.

Welcome .
Click to expand...
I agree — reta's capacity to go after intramuscular and organ fat definitely makes it noticeable. The only thing giving me pause is the rise in heart rate plus sympathetic activation, so over the next few weeks I'll be watching those closely. Yesterday I reconstituted a vial and injected 2mg reta together with 4mg tirz. Before that I had been at 5mg reta and noticed feeling somewhat sluggish, though calm. Could be placebo, but across roughly the first 16 hours today I've felt far more awake and energetic, despite taking in very few calories. My heart rate looks the same, yet I feel more switched on without it feeling overwhelming. Hunger is still blunted, so tirz continues to do what it's supposed to, which is the whole reason I'm staying on it. Over the next several days I'll track how this develops. Starting at 2mg made me a bit anxious, but so far I'm happy with how it's going.

The prediabetes reversal caught me off guard as well. I was only borderline, so not deep into the prediabetic a1c range, yet it still shifted by 0.2 points during that period. My guess is that slower gastric emptying prevents glucose from surging at any single moment and instead trickles it into the bloodstream across the day. GIP additionally assists insulin in reaching the cells and boosts insulin secretion, and combined that keeps blood sugar steady without draining energy.
 
Rawbiotix said:

From a research perspective, what draws attention to the visceral and liver fat angle is reta's glucagon component. The GIP/GLP-1 side is well covered by tirz, but glucagon receptor activation works differently, and the hepatic fat data in particular deserves close attention. Combining the two at lower doses each, in order to keep side effects in check while retaining the metabolic mechanisms, is a logical approach. Reversing prediabetes within 4 weeks is a strong result — labs don't lie.

Welcome .
Click to expand...
My most recent lab work isn't all that fresh, though I did get a panel done in November. Reta was started in September, and by that November draw my fatty liver indicators had dropped across the board, which makes me believe it's effective.
 
Interesting conversation. I’ve been taking Zepbound 15 for 2 months now, getting it through Lilly Direct. Before this, I was on Zepbound (every dose) for 8 months, but my insurance stopped covering it. Then I did 6 months on Wegovy 2.4 after Zep, until insurance also dropped that. So far I’ve dropped 69 pounds thanks to the meds, changing what I eat, and using an elliptical.

What really catches my attention is the glucagon part of Reta, and I wonder what kind of effect it could have on visceral fat. I’m roughly 10-15 pounds away from switching to maintenance mode.

I feel like a pinball, bouncing between grey Reta or Tir as my next move, or maybe compounded Tirzepatide.
 
bingbong1235 said:

I get where you're coming from — honestly, finding what works usually takes a while and involves some trial and error. Early on, a few folks took advantage of me and I ended up getting scammed. It's something that happens, and losing money that way feels awful. There are plenty of people who target newcomers because they're desperate to get their hands on something. Don't throw in the towel just yet... there are still lots of solid, trustworthy sources around. Before you buy, give yourself time and collect as much info as you can. For your first few purchases, stay careful, and my suggestion is to begin with a low dose and go slow. Once you manage to get the right product, everything becomes worthwhile.
Click to expand...
My impression is that everything happens behind closed doors. Until you've earned their trust, nobody will actually tell you "Come over here. Go see my friend but mums the word."
 
It's unfortunate that it turned out this way. And all these other folks out there simply exploiting others — those are genuinely awful, awful individuals doing that. Some folks are just trying to get by spending as little as possible, since times are tough right now, and maybe that person is severely overweight and in need of assistance. But on the other hand, there are also those other types lurking around trying to get people shut down. That then opens the door for others to scam people. Back when I was younger, nothing was like this. Well, some of it existed, but not on the massive scale we see today. I'm in my later 60s and just hoping to manage whatever remaining years I have left. Personally, I want a few things but haven't obtained them yet — maybe I will, maybe I won't, I don't know, we'll just see how it goes. But guys and gals out there, watch out for who you do business with — research and search and research. The best approach is to make a friend and go that route. Alright, that's my 2 cents.
 
bingbong1235 said:

Hey all,

I've been reading for a while without posting. Peptides are still quite new to me, though I began tirz roughly 4 weeks back and am starting to notice changes. My weight has always trended high, and it kept getting worse over time. So far I'm down about 12 pounds. Recent labs came back, and after just 4 weeks of use, my prediabetes is no longer present and my triglyceride levels dropped sharply. My watch isn't giving sleep apnea alerts anymore. I've felt somewhat fatigued and anhedonic, but that has leveled out.

I also picked up some reta not long ago, so I'll add it in soon, aiming for the glucagon effects and a boost in energy. My thinking was that at a low dose it might reduce visceral and liver fat. I'm considering trimming the tirz dose slightly and continuing it for appetite control and anti-inflammatory benefits, then testing how a starter dose of reta performs alongside it.

Given how new I am to this, I've already got a fair amount stocked: 1950mg tirz and 950mg reta over 8 kits. I might hold off on buying more until I know whether I like reta. Bac water is somewhat scarce at the moment, so that could hold me back. I'm putting together a solid set of supplies and kits. Trying to cover every angle and reduce risk wherever I can. Glad to be here and to keep learning.
Click to expand...
My goal is to turn my diabetes around. A medspa was my provider, but their prices were too high and they increased my Tirz dose too quickly, so my weight loss was minimal. For a short while they had me on Reta, which helped me drop a bit more. Right now I'm not taking any GLP1 at all — I just want to restart on my own schedule and my own dosage, with hopes of a better outcome. Wishing you the best of luck!!
 
Great results. I had a comparable run with Reta (plus a lot of my own gains before that) bringing down several biomarkers (A1C, BP, and so on). I lost roughly 45 lbs over 12 months, and my cardiologist has cut my BP meds down to about a quarter, with a possibility of stopping them altogether.
 
Peptide_J said:

Rawbiotix said:

From a research perspective, what draws attention to the visceral and liver fat angle is reta's glucagon component. The GIP/GLP-1 side is well covered by tirz, but glucagon receptor activation works differently, and the hepatic fat data in particular deserves close attention. Combining the two at lower doses each, in order to keep side effects in check while retaining the metabolic mechanisms, is a logical approach. Reversing prediabetes within 4 weeks is a strong result — labs don't lie.

Welcome .
Click to expand...
My most recent lab work isn't all that fresh, though I did get a panel done in November. Reta was started in September, and by that November draw my fatty liver indicators had dropped across the board, which makes me believe it's effective.
Click to expand...
That's great to hear. It's surprising how fast these can produce measurable shifts in bloodwork.

3 days back I pinned 4mg tirz along with 3mg reta. There's a slight burning sensation in my stomach area, though nothing like the elevated heart rate or allodynia others describe. Should I bump the dose up, or give it a few more weeks? GI issues have been barely noticeable too. Considering injecting 2mg more reta later today and crossing my fingers the side effects stay manageable...
 
mgonzo said:

Interesting conversation. I’ve been taking Zepbound 15 for 2 months now, getting it through Lilly Direct. Before this, I was on Zepbound (every dose) for 8 months, but my insurance stopped covering it. Then I did 6 months on Wegovy 2.4 after Zep, until insurance also dropped that. So far I’ve dropped 69 pounds thanks to the meds, changing what I eat, and using an elliptical.

What really catches my attention is the glucagon part of Reta, and I wonder what kind of effect it could have on visceral fat. I’m roughly 10-15 pounds away from switching to maintenance mode.

I feel like a pinball, bouncing between grey Reta or Tir as my next move, or maybe compounded Tirzepatide.
Click to expand...
Honestly, either reta or tirz is a solid pick. If your priority is a longer track record, more supporting data, and appetite suppression that hits harder, tirz is the way to go. With reta, you tend to get more daytime energy, quicker scale movement at smaller doses, and it might help with fat around the muscles and liver.

I've only been running reta a few days myself. Nothing alarming so far, just a bit of extra warmth and possibly a bit more get-up-and-go. From my own read and what I've come across, reta's appetite blunting seems somewhat milder. Those final 15 pounds are often the hardest to budge, so reta might slice through them a touch more effectively.

Whether you go compounded or gray comes down to how much risk you're willing to accept. My take: a trustworthy gray supplier who hands over COAs, plus filtering your vials and keeping a close eye out for side effects, ends up being much cheaper. Word I've heard is that the US compounders and resellers pull their API from the same Chinese outfits that supply some of these grey sellers.
 
CoquiPrincess said:

bingbong1235 said:

Hey all,

I've been reading for a while without posting. Peptides are still quite new to me, though I began tirz roughly 4 weeks back and am starting to notice changes. My weight has always trended high, and it kept getting worse over time. So far I'm down about 12 pounds. Recent labs came back, and after just 4 weeks of use, my prediabetes is no longer present and my triglyceride levels dropped sharply. My watch isn't giving sleep apnea alerts anymore. I've felt somewhat fatigued and anhedonic, but that has leveled out.

I also picked up some reta not long ago, so I'll add it in soon, aiming for the glucagon effects and a boost in energy. My thinking was that at a low dose it might reduce visceral and liver fat. I'm considering trimming the tirz dose slightly and continuing it for appetite control and anti-inflammatory benefits, then testing how a starter dose of reta performs alongside it.

Given how new I am to this, I've already got a fair amount stocked: 1950mg tirz and 950mg reta over 8 kits. I might hold off on buying more until I know whether I like reta. Bac water is somewhat scarce at the moment, so that could hold me back. I'm putting together a solid set of supplies and kits. Trying to cover every angle and reduce risk wherever I can. Glad to be here and to keep learning.
Click to expand...
My goal is to turn my diabetes around. A medspa was my provider, but their prices were too high and they increased my Tirz dose too quickly, so my weight loss was minimal. For a short while they had me on Reta, which helped me drop a bit more. Right now I'm not taking any GLP1 at all — I just want to restart on my own schedule and my own dosage, with hopes of a better outcome. Wishing you the best of luck!!
Click to expand...
Being able to set your own dose is a big plus. However you manage it, restarting these is worth it — yet if you keep your own stock and titrate upward, that's genuinely useful, provided you watch out for side effects and avoid ramping up too quickly.
 
literallylit said:

Great results. I had a comparable run with Reta (plus a lot of my own gains before that) bringing down several biomarkers (A1C, BP, and so on). I lost roughly 45 lbs over 12 months, and my cardiologist has cut my BP meds down to about a quarter, with a possibility of stopping them altogether.
Click to expand...
Splitting your blood pressure pills into quarters plus dropping 45lb across 12 months — that's seriously impressive. Great work. Elevated BP tied to excess weight is genuinely nasty stuff; it harms your kidneys and blood vessels while ramping up inflammation. Good to hear it improves so fast once the pounds come off.
 
bingbong1235 said:

mgonzo said:

Interesting conversation. I’ve been taking Zepbound 15 for 2 months now, getting it through Lilly Direct. Before this, I was on Zepbound (every dose) for 8 months, but my insurance stopped covering it. Then I did 6 months on Wegovy 2.4 after Zep, until insurance also dropped that. So far I’ve dropped 69 pounds thanks to the meds, changing what I eat, and using an elliptical.

What really catches my attention is the glucagon part of Reta, and I wonder what kind of effect it could have on visceral fat. I’m roughly 10-15 pounds away from switching to maintenance mode.

I feel like a pinball, bouncing between grey Reta or Tir as my next move, or maybe compounded Tirzepatide.
Click to expand...
Honestly, either reta or tirz is a solid pick. If your priority is a longer track record, more supporting data, and appetite suppression that hits harder, tirz is the way to go. With reta, you tend to get more daytime energy, quicker scale movement at smaller doses, and it might help with fat around the muscles and liver.

I've only been running reta a few days myself. Nothing alarming so far, just a bit of extra warmth and possibly a bit more get-up-and-go. From my own read and what I've come across, reta's appetite blunting seems somewhat milder. Those final 15 pounds are often the hardest to budge, so reta might slice through them a touch more effectively.

Whether you go compounded or gray comes down to how much risk you're willing to accept. My take: a trustworthy gray supplier who hands over COAs, plus filtering your vials and keeping a close eye out for side effects, ends up being much cheaper. Word I've heard is that the US compounders and resellers pull their API from the same Chinese outfits that supply some of these grey sellers.
Click to expand...
 
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