New Here — Hello from North Carolina

LetsGoWolves

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Hey everyone! I'm Mike, 57 years old, and I've spent the better part of my life trying to shed pounds. My experience runs the gamut — from old-school meal logging and planning, to phentermine, to several different GLP-1 medications. Football left me with a collection of injuries, and these days I'm the proud owner of a metal hip.

Starting from my top weight of 380 pounds, phentermine helped me drop roughly 75 — until my hip surgery forced me to pause. Once I'd recovered and tried again, I turned out to be one of those people whose body simply stopped responding to phentermine's signals, so it no longer did anything for me.

That's when my MD put me on semaglutide — right in the middle of the shortage. Given my size, he felt confident I could begin at 1.7 mg. For 3 days after that first dose, the smell of any food made me vomit, but I stuck with it for a couple of months. The 2.4 mg dose, however, was more than I could take. We paused, and then my insurance quit covering GLP-1's altogether. After 6 months of struggling again with tracking and exercise — and regaining about 40 of the 80 pounds I'd lost — I located a compounding pharmacy within my budget and restarted semaglutide, this time titrating up slowly. That round took off about 30 pounds. Then I heard our insurance would cover Zepbound, so it was back to the MD to give it a try.

Zepbound has been remarkable for my OSA, but my weight loss has slowed to roughly 2 pounds/month. And when we signed up for next year's benefits, we learned that GLP-1 copays for weight loss on our plan are jumping from $25/month to $200/month.

I work in health care, by the way. It's incredibly frustrating that a hospital system would rather pay for the long-term consequences of obesity than for GLP-1 therapy.

Outside of weight loss: I've been a hospital pharmacist for 23 years, I'm married, and we have 3 sons. In February of this year, after my mom passed away, we moved into my dad's house to care for him as he battles Alzheimer's. So when I'm not at the hospital, I'm at home keeping an 81 year old man in line. 😀
 
Welcome! Which GLP-1s do you intend to research for your weight loss goals? That's my aim too, so I'm curious what others are exploring for their own objectives.

You mentioned working in healthcare, right? What's your take on people injecting peptides into themselves, or has anyone ever admitted to you that they were on peptides? I'm asking because I've heard some stories.
 
At our hospital, nobody has come in saying they used anything besides GLP-1's. That said, a handful of patients have arrived with intestinal blockages after obtaining theirs from pop-up wellness boutiques. I never talked to those patients myself, but the technician who took their home med lists told me about it, and the pattern that keeps coming up is that people are confused about how to draw up their dose, may be moving through the titration too fast, and may be going somewhat above the manufacturer's recommended dose.

On a related note, my wife may be receiving cagrilintide as part of a clinical trial. A biomedical research office roughly 10 minutes from our home conducts a number of genuinely interesting studies, and besides providing the product they compensate participants quite well. According to her, the side effects she has are just strong enough to make her believe she isn't getting the placebo, and she is dropping a few pounds as well.

All in all, I have no objection to people taking charge of their own health, provided they accept the responsibility of learning what they need to learn before they begin. Going in blindly and then expecting a miracle cure for whatever went wrong is not reasonable. Putting chemicals into your body carries risk even when you know what you're doing. Doing it after 15 minutes on Google is suicidal.
 
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