My Experience With Retatrutide: What Appetite Suppression Feels Like

[Imfrijole]

I've been using retatrutide for roughly 10 weeks now. My dose started at 1 mg and has climbed to 4 mg. I wanted to describe how appetite suppression actually presents for me, since a lot of discussion focuses on Reta not producing much appetite suppression. My height is 5'10", my starting weight was 226 lbs, and I'm currently sitting around 212 lbs. The majority of that drop came after I reached 2 mg.

People typically talk about four sensations: less food noise, blunted cravings, early fullness, and dampened food pleasure. Of those, only 1 truly applies to me: I feel full faster.

The "food noise" hasn't gone anywhere. I still think about meals and snacks the same way I always have, and food still gives me pleasure. If anything, I continue to enjoy eating and get genuine satisfaction from meals. I still drink beer and enjoy that too.

My cravings have gone down, but that has more to do with getting full sooner than with losing interest in food. I eat smaller portions because I'm satisfied earlier, not because I feel disconnected from food.

For me, that early fullness is a positive: I'm still very much a food-lover, and I don't want to lose the joy of eating. Reta simply helps me feel satisfied with less. I hope this helps some people understand the difference. Maybe if I keep titrating up, the other elements of appetite suppression will kick in, but I'm very happy with the feeling I get now.

 

[Florus2026]

Imfrijole said:

I've been using retatrutide for roughly 10 weeks now. My dose started at 1 mg and has climbed to 4 mg. I wanted to describe how appetite suppression actually presents for me, since a lot of discussion focuses on Reta not producing much appetite suppression. My height is 5'10", my starting weight was 226 lbs, and I'm currently sitting around 212 lbs. The majority of that drop came after I reached 2 mg.

People typically talk about four sensations: less food noise, blunted cravings, early fullness, and dampened food pleasure. Of those, only 1 truly applies to me: I feel full faster.

The "food noise" hasn't gone anywhere. I still think about meals and snacks the same way I always have, and food still gives me pleasure. If anything, I continue to enjoy eating and get genuine satisfaction from meals. I still drink beer and enjoy that too.

My cravings have gone down, but that has more to do with getting full sooner than with losing interest in food. I eat smaller portions because I'm satisfied earlier, not because I feel disconnected from food.

For me, that early fullness is a positive: I'm still very much a food-lover, and I don't want to lose the joy of eating. Reta simply helps me feel satisfied with less. I hope this helps some people understand the difference. Maybe if I keep titrating up, the other elements of appetite suppression will kick in, but I'm very happy with the feeling I get now.

That matches my experience exactly — Reta's biggest impact on me was the same thing, even at the small dose I take, roughly 1g. My cravings are lower as well, and although chocolate and similar foods are still part of what I eat, they stop feeling as satisfying sooner.

One consequence of feeling full sooner, though, is that I pay closer attention to what I decide to eat. Choosing wisely may be just a little bit easier.

 

[sheilarae74]

This weekend it hit me just how different my eating patterns are now that I've been taking reta. Every warm weather holiday we fire up the grill, and in past years I'd be eagerly anticipating all the tasty things I'd get to enjoy. This time around my reaction was just "meh". I ate a hamburger plus some macaroni salad, and that was more than enough. We typically make enough food to last 2 days, but today I haven't had any desire for leftovers. By this point I'd usually have eaten a hot dog, a brat, potato salad, baked beans, and more. Eating just isn't exciting the way it used to be.

On Monday I plan to grill some chicken breast so I can get protein in for next week. It's become clear to me how much better I feel when I'm getting my muscle-building fuel.

 

[sheilarae74]

Florus2026 said:

Imfrijole said:

I've been using retatrutide for roughly 10 weeks now. My dose started at 1 mg and has climbed to 4 mg. I wanted to describe how appetite suppression actually presents for me, since a lot of discussion focuses on Reta not producing much appetite suppression. My height is 5'10", my starting weight was 226 lbs, and I'm currently sitting around 212 lbs. The majority of that drop came after I reached 2 mg.

People typically talk about four sensations: less food noise, blunted cravings, early fullness, and dampened food pleasure. Of those, only 1 truly applies to me: I feel full faster.

The "food noise" hasn't gone anywhere. I still think about meals and snacks the same way I always have, and food still gives me pleasure. If anything, I continue to enjoy eating and get genuine satisfaction from meals. I still drink beer and enjoy that too.

My cravings have gone down, but that has more to do with getting full sooner than with losing interest in food. I eat smaller portions because I'm satisfied earlier, not because I feel disconnected from food.

For me, that early fullness is a positive: I'm still very much a food-lover, and I don't want to lose the joy of eating. Reta simply helps me feel satisfied with less. I hope this helps some people understand the difference. Maybe if I keep titrating up, the other elements of appetite suppression will kick in, but I'm very happy with the feeling I get now.

That matches my experience exactly — Reta's biggest impact on me was the same thing, even at the small dose I take, roughly 1g. My cravings are lower as well, and although chocolate and similar foods are still part of what I eat, they stop feeling as satisfying sooner.

One consequence of feeling full sooner, though, is that I pay closer attention to what I decide to eat. Choosing wisely may be just a little bit easier.

Same here. These days, one or two cookies is enough for me, whereas before I'd have six.

 

[Spork]

I'm a bit envious of people who were able to jump right into reta. When it comes to curbing appetite, it kind of feels like "you don't know what you don't know."

I'm considering stacking reta with my tirzepatide since I'm currently at 15mg of tirz. What's intriguing about the clinical trials is that even though retatrutide showed "inferior" appetite suppression compared to tirzepatide, participants on retatrutide ended up losing more weight — so clearly that glucagon is doing its job.

 

[Sundaycandy]

Right now I'm only taking 1mg of Reta, and honestly my experience has been kind of the reverse of what a lot of people describe. Whenever something takes my attention — whether that's work, working out, or playing games — eating just slips my mind entirely. Back before Reta, I'd be watching the clock waiting for my next meal, and the moment I thought about food my stomach would start rumbling.

But on the other hand, I can't say I've noticed myself filling up any quicker so far. The reason I'm eating less mostly comes down to the fact that I go most of the day without eating, and there's only so much I can pack into the meals I do actually remember to have lol

 

[Imfrijole]

sheilarae74 said:

This weekend it hit me just how different my eating patterns are now that I've been taking reta. Every warm weather holiday we fire up the grill, and in past years I'd be eagerly anticipating all the tasty things I'd get to enjoy. This time around my reaction was just "meh". I ate a hamburger plus some macaroni salad, and that was more than enough. We typically make enough food to last 2 days, but today I haven't had any desire for leftovers. By this point I'd usually have eaten a hot dog, a brat, potato salad, baked beans, and more. Eating just isn't exciting the way it used to be.

On Monday I plan to grill some chicken breast so I can get protein in for next week. It's become clear to me how much better I feel when I'm getting my muscle-building fuel.

That matches my experience closely! On Mother's Day I prepared food for 15 people. The spread included BBQ ribs, mac salad, kielbasa, and other dishes, plus 2 cakes. I ate 1 medium-sized plate and felt so stuffed that I couldn't eat anything else all night. The couple of beers I had probably contributed to that fullness, but still, under normal circumstances I would have gone back for 2 or 3 plates.

 

[Imfrijole]

Sundaycandy said:

Right now I'm only taking 1mg of Reta, and honestly my experience has been kind of the reverse of what a lot of people describe. Whenever something takes my attention — whether that's work, working out, or playing games — eating just slips my mind entirely. Back before Reta, I'd be watching the clock waiting for my next meal, and the moment I thought about food my stomach would start rumbling.

But on the other hand, I can't say I've noticed myself filling up any quicker so far. The reason I'm eating less mostly comes down to the fact that I go most of the day without eating, and there's only so much I can pack into the meals I do actually remember to have lol

Plenty of accounts I've come across describe effects that don't match mine at all. At 1mg, nothing stood out to me — in fact, during my first 2 weeks on 1 mg, my food intake actually went up. That said, my tolerance tends to run high across the board. Based on what I've seen, plenty of folks don't experience much appetite suppression until they reach higher doses, so I figured I'd spell out my own reaction to keep people from writing off Reta before giving it a shot. For me, it's been pretty fantastic.

 

[BNLFL]

On this latest 8mg dose, appetite is way down and fullness comes fast. Possibly too much; time will tell.

 

[Imfrijole]

BNLFL said:

On this latest 8mg dose, appetite is way down and fullness comes fast. Possibly too much; time will tell.

I figured that higher doses of MGs might bring about much more appetite suppression. As you moved up in dose, did the effect intensify, or were you increasing because the suppression was fading the longer you stayed at a particular MG?

 

[longestyards]

Imfrijole said:

I've been using retatrutide for roughly 10 weeks now. My dose started at 1 mg and has climbed to 4 mg. I wanted to describe how appetite suppression actually presents for me, since a lot of discussion focuses on Reta not producing much appetite suppression. My height is 5'10", my starting weight was 226 lbs, and I'm currently sitting around 212 lbs. The majority of that drop came after I reached 2 mg.

People typically talk about four sensations: less food noise, blunted cravings, early fullness, and dampened food pleasure. Of those, only 1 truly applies to me: I feel full faster.

The "food noise" hasn't gone anywhere. I still think about meals and snacks the same way I always have, and food still gives me pleasure. If anything, I continue to enjoy eating and get genuine satisfaction from meals. I still drink beer and enjoy that too.

My cravings have gone down, but that has more to do with getting full sooner than with losing interest in food. I eat smaller portions because I'm satisfied earlier, not because I feel disconnected from food.

For me, that early fullness is a positive: I'm still very much a food-lover, and I don't want to lose the joy of eating. Reta simply helps me feel satisfied with less. I hope this helps some people understand the difference. Maybe if I keep titrating up, the other elements of appetite suppression will kick in, but I'm very happy with the feeling I get now.

My situation is pretty close to that. These days I'm on 5 mg, and from the 4 mg point onward, even tiny servings leave me feeling stuffed. A little sandwich is enough now — after that, eating any more just isn't possible. Still, the quieting of food noise kicked in way back at 0.5 mg for me. What food noise can't fix is the bodily sensation of hunger. For example, I can tell I'm hungry, and the smell of food will make me salivate. But when it comes to the mental side of hunger — the constant wondering about the next meal — reta is a huge help. I just eat when my body signals some hunger. That said, starting at 4 mg, the genuine suppression shows up as getting full extremely quickly and feeling seriously nauseous if I attempt to eat past that point, so I avoid it and deliberately keep my portions very small.

 

[BNLFL]

Imfrijole said:

BNLFL said:

On this latest 8mg dose, appetite is way down and fullness comes fast. Possibly too much; time will tell.

I figured that higher doses of MGs might bring about much more appetite suppression. As you moved up in dose, did the effect intensify, or were you increasing because the suppression was fading the longer you stayed at a particular MG?

The decline happened over roughly the past 4 weeks. The sensation matches what I had back when I first began taking this at 2mg.

 

[bgddy32]

Imfrijole said:

I've been using retatrutide for roughly 10 weeks now. My dose started at 1 mg and has climbed to 4 mg. I wanted to describe how appetite suppression actually presents for me, since a lot of discussion focuses on Reta not producing much appetite suppression. My height is 5'10", my starting weight was 226 lbs, and I'm currently sitting around 212 lbs. The majority of that drop came after I reached 2 mg.

People typically talk about four sensations: less food noise, blunted cravings, early fullness, and dampened food pleasure. Of those, only 1 truly applies to me: I feel full faster.

The "food noise" hasn't gone anywhere. I still think about meals and snacks the same way I always have, and food still gives me pleasure. If anything, I continue to enjoy eating and get genuine satisfaction from meals. I still drink beer and enjoy that too.

My cravings have gone down, but that has more to do with getting full sooner than with losing interest in food. I eat smaller portions because I'm satisfied earlier, not because I feel disconnected from food.

For me, that early fullness is a positive: I'm still very much a food-lover, and I don't want to lose the joy of eating. Reta simply helps me feel satisfied with less. I hope this helps some people understand the difference. Maybe if I keep titrating up, the other elements of appetite suppression will kick in, but I'm very happy with the feeling I get now.

Absolutely, though when I was taking 2mg once a week, food was completely unappealing—looking at it felt like looking at a stone. Since I started splitting that 2mg dose, I get the same effect you're describing: feeling full sooner. For me, honestly, that matters more because I have to hit my protein goals, and at 2mg there was no way I could manage it. It's fascinating how doses hit different people in different ways. Also, the Eli Lilly study found that a 4mg maintenance dose worked very well over the long term too, with 20% weight loss! I'm a firm believer in minimum effective dosing for myself, so I figure that's where I'll land as I move up. Best of luck to you!!