My Cagri & Reta experience

[Kyli]

Hi all, I want to tell you about how Cagri has gone for me so far.

Where I'm coming from

Retatrutide remains my base peptide — 3 mg twice per week, roughly 6 mg/week. Around two weeks back, trouble with Reta appeared. I was behind the wheel and out of nowhere came hunger. Not ordinary hunger and not food noise — this was "I NEED FOOD RIGHT NOW."

I attempted to ride it out, figuring it might be a one-off. Sadly, it kept returning over and over. Sure, I could have bumped my Reta from 3 mg to 3.5 mg twice a week (7 mg/week), but truthfully I had no wish to escalate. It's been just a bit over three months on it, and I don't want to be inching toward the ceiling dose this early.

It was precisely for these kinds of "emergency" situations that I picked up Cagri some time ago, intending to stack it with Reta.

I researched heavily in advance yet never found a definitive answer. Some people called Cagri a game changer; for others it was — how to put it — simply bad. So I chose to test it on myself.

Day by day

My first shot went in on 18.08.2026: 250 mcg of Cagri, roughly 3:00 PM. The next Reta injection stayed on schedule the following morning.

18.08. — Nothing at all. Zero effects.

19.08. — I realized I'd overslept. Usually I'm awake at 5 AM to walk my dogs and handle things. Instead I stayed asleep until the dogs roused me because they needed to go out. As for hunger, the day matched what came before.

20.08. — Waking up was the same story — I slept until roughly 6 AM. Then I had to drive to my other pets, and behind the wheel I sensed something wasn't right. My reaction time is normally razor-sharp. Today it wasn't. To be clear: nowhere close to "I can't drive." But also nowhere close to the crisp, clear-headed driving Adamax gives me.

By about 10 AM I was home eating breakfast. That's when the shift really hit me. With Reta alone, food still brought me pleasure. Today… I ate with zero enjoyment. The food tasted fine, but I got nothing out of it — I genuinely can't put it into words. Meanwhile, no early satiety either. I simply quit eating because it wasn't enjoyable.

After breakfast I went to bed and remained there until 2 PM. So the whole "productive" portion of the day vanished. I wouldn't say I slept the entire time, but I couldn't get up either. Even right now, I don't truly feel like working.

Full disclosure — my current stack

• Morning, daily: KPV, GHK-Cu, hCG, 5-Amino-1MQ, BPC-157
  
• Mon/Wed/Fri: MOTs-C
  
• Mon + Fri: TB-500
  
• Mon–Fri, 10:00 AM: Adamax + Selank
  
• Afternoon: 5-Amino-1MQ + BPC-157
  
• Mon–Fri, before bed: Tesa

What's next

Right now I haven't made up my mind about staying on Cagri. The other option would be Elora, but I have none on hand, and it currently runs about 350 USD for 10×10 mg. I realize that's nothing next to white Tirz, yet it's still steep — particularly since you need 250 mcg of Cagri versus roughly 2 mg of Elora. So I'd prefer to remain with Cagri and try to adapt to it.

I figure I'll pin the next 250 mcg tomorrow and test a few things to lift my performance. At the moment I see three options:

1. Caffeine — frankly, I was happy to have escaped caffeine thanks to Semax and now Adamax. I don't want to head back down that path.
   
2. Methylene blue — I bought it some time ago but never tried it, so I'd give it a go.
   
3. Nicotine — I've taken it before but never truly noticed anything, especially while on Adamax. I'll try it once more.

According to some, this fatigue fades after roughly four weeks. So for the time being, I'll be the human guinea pig and see where it leads.

I'll keep you posted.

 

[FunkyWhales78]

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

 

[Kyli]

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

 

[FunkyWhales78]

Kyli said:

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

Fair enough regarding cutting calories. A lot of folks on GLP1s go for much bigger deficits, and I probably should have checked first.

Good to hear the biohacking crowd is unaffected. Around 1.2 billion people are, though. That's exactly why companies such as Phillip Morris are so eager to push alternative delivery methods now that smoking has declined. A month means nothing; I'd think most people could quit a twenty a day habit without much trouble. If you truly see no issue, that's fine, but surely you have some sense of what I'm getting at? Nicotine has more people hooked than any other drug worldwide.

 

[Kyli]

FunkyWhales78 said:

Kyli said:

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

Fair enough regarding cutting calories. A lot of folks on GLP1s go for much bigger deficits, and I probably should have checked first.

Good to hear the biohacking crowd is unaffected. Around 1.2 billion people are, though. That's exactly why companies such as Phillip Morris are so eager to push alternative delivery methods now that smoking has declined. A month means nothing; I'd think most people could quit a twenty a day habit without much trouble. If you truly see no issue, that's fine, but surely you have some sense of what I'm getting at? Nicotine has more people hooked than any other drug worldwide.

True, but cigarettes are what you're describing. Or products such as Zyn. Nicotine, though, isn't the same thing. Each of those is a chemical blend built to hook people. A US cigarette holds roughly 600 ingredients. That's absurd. It also explains why addiction develops.

From what I looked into (unfortunately that was last year and I don't remember all the details), nicotine itself does not cause addiction. One of the biohackers (Huberman, I believe?) mentioned this. Studies reached the same conclusion. That's also why other tobacco forms, such as cigars or pipes, don't create dependence.

Many of my friends smoke cigars. Yet not one of them has ever leapt from the dinner table and rushed to my balcony to light up. They want the right atmosphere instead — perhaps a whiskey. A cool setting where the cigar (or pipe) can be savored.

FunkyWhales78 said:

Kyli said:

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

Fair enough regarding cutting calories. A lot of folks on GLP1s go for much bigger deficits, and I probably should have checked first.

Good to hear the biohacking crowd is unaffected. Around 1.2 billion people are, though. That's exactly why companies such as Phillip Morris are so eager to push alternative delivery methods now that smoking has declined. A month means nothing; I'd think most people could quit a twenty a day habit without much trouble. If you truly see no issue, that's fine, but surely you have some sense of what I'm getting at? Nicotine has more people hooked than any other drug worldwide.

Yet that IS the period in question. Fatigue usually clears in roughly 4 weeks, most people report. So that's the stretch I need to get through. To keep producing. Last year I quit nicotine since the benefit no longer justified the cost. I mean both the money and the mental burden of yet another daily chore. That's why I simply dropped it. At first I'd skip the patch on certain days. Then I chose to stop taking it altogether. And that was that.

PS: I injected another 250 mcg Cagri today. The Drug Plotter puts me around 436 mcg of Cagri in my system now. We'll see how it works. So far, I can't tell what's happening. My weight did rise over the past days, though. Probably mostly water, I think.

 

[FunkyWhales78]

Kyli said:

FunkyWhales78 said:

Kyli said:

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

Fair enough regarding cutting calories. A lot of folks on GLP1s go for much bigger deficits, and I probably should have checked first.

Good to hear the biohacking crowd is unaffected. Around 1.2 billion people are, though. That's exactly why companies such as Phillip Morris are so eager to push alternative delivery methods now that smoking has declined. A month means nothing; I'd think most people could quit a twenty a day habit without much trouble. If you truly see no issue, that's fine, but surely you have some sense of what I'm getting at? Nicotine has more people hooked than any other drug worldwide.

True, but cigarettes are what you're describing. Or products such as Zyn. Nicotine, though, isn't the same thing. Each of those is a chemical blend built to hook people. A US cigarette holds roughly 600 ingredients. That's absurd. It also explains why addiction develops.

From what I looked into (unfortunately that was last year and I don't remember all the details), nicotine itself does not cause addiction. One of the biohackers (Huberman, I believe?) mentioned this. Studies reached the same conclusion. That's also why other tobacco forms, such as cigars or pipes, don't create dependence.

Many of my friends smoke cigars. Yet not one of them has ever leapt from the dinner table and rushed to my balcony to light up. They want the right atmosphere instead — perhaps a whiskey. A cool setting where the cigar (or pipe) can be savored.

FunkyWhales78 said:

Kyli said:

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

The whole point is that losing weight requires the body to be in a deficit. Right now I'm running a daily deficit of roughly 500-750 kcal.

FunkyWhales78 said:

Could it be that your calorie intake is too low? Maybe that sudden "I need food now" feeling is your body genuinely asking for fuel.

And please, for everything holy, keep away from nicotine. Kicking that habit is brutal.

I have no clue what you mean. I used nicotine daily for around a month and quitting was completely painless for me. Nor do I know anyone in the Biohacking Community who struggled to stop nicotine.

Fair enough regarding cutting calories. A lot of folks on GLP1s go for much bigger deficits, and I probably should have checked first.

Good to hear the biohacking crowd is unaffected. Around 1.2 billion people are, though. That's exactly why companies such as Phillip Morris are so eager to push alternative delivery methods now that smoking has declined. A month means nothing; I'd think most people could quit a twenty a day habit without much trouble. If you truly see no issue, that's fine, but surely you have some sense of what I'm getting at? Nicotine has more people hooked than any other drug worldwide.

Yet that IS the period in question. Fatigue usually clears in roughly 4 weeks, most people report. So that's the stretch I need to get through. To keep producing. Last year I quit nicotine since the benefit no longer justified the cost. I mean both the money and the mental burden of yet another daily chore. That's why I simply dropped it. At first I'd skip the patch on certain days. Then I chose to stop taking it altogether. And that was that.

PS: I injected another 250 mcg Cagri today. The Drug Plotter puts me around 436 mcg of Cagri in my system now. We'll see how it works. So far, I can't tell what's happening. My weight did rise over the past days, though. Probably mostly water, I think.

The addiction comes from the nicotine. The rest of the chemicals do serious damage to your health. For years I mixed my own e-liquid, so I always knew exactly what went into it, and when I tried Nicotine Replacement Therapy I discovered it hooked me just the same. Pipes absolutely can create dependence too; it's simply much rarer, because people use them differently nowadays since it's more of a niche thing.



Look further back in history, when pipe smoking was more widespread. Disposable clay pipes used to be sold already loaded. The cigar smokers you mention are occasional users. My mum died of a smoking-related cancer, and she smoked small cigars. Believe me, she was addicted. Over the years I've met plenty of casual nicotine users who, the longer they kept at it, found it harder and harder to take breaks. That became really obvious when mixing cannabis with tobacco was popular.



Anyway, you don't want a lecture, and you have done your research. I just thought it fair to say this, as a nicotine habit is a horrible thing to kick.



Good luck with Capri. I'll read any updates with interest.

 

[Kyli]

Cagri, week 1 — flatness, sleeplessness, and 4 kg from nowhere

21.08.2026 — I injected my 2nd Cagri dose today, 250 mcg, since hunger showed up this morning. To counter the tiredness I also gave nicotine a try for the 1st time — 14 mg. Honestly, though, tiredness isn't the whole story. There's also this… German has a word for it: "Kein Bock." The nearest English equivalent would be "total apathy."

Lunch felt odd. I was hungry. Yet while the food tasted good, I simply couldn't get it down — every bite had to be forced. Diarrhea followed after lunch.

22.08.2026 — My usual routine is bed at 10 PM, asleep by roughly 11. Last night, though, I lay awake until about 1:30 AM. From that short sleep I got up at 5:30 — fairly standard for me, because I have to drive out to my country house and feed the chickens and the other animals.

That morning I did all of my injections except one: Reta was only 2.5 mg, since the vial had run dry and I didn't feel like mixing up a fresh one. Nicotine stayed at 14 mg.

At the country house I realized I was surprisingly fit despite the much shorter sleep. So I got to work — hauling the winter firewood into the barn, among other chores. My stamina, though, wasn't up to much. I was sweating far more than on a typical day.

My neighbor then called me over and handed me a glass of ice-cold Coke. I couldn't say no. It was bad, though. Really bad. The taste was familiar, but to me it came across as oversweet. And that satisfaction an ice-cold Coke gives you? Gone. It was nothing but a sweet "soup."

Driving home I passed a speed trap in a place where one had never been before — and I spotted it from far away. So Adamax was clearly doing its job.

23.08.2026 — The scale this morning showed a gain. Not grams — 4 kg. In a single week. That shouldn't be possible. It would mean roughly 30,000 kcal eaten, and I didn't eat that. I was plainly in a deficit. Two things stood out, though. This morning I had a weird sense of fullness, AND I could somehow still feel yesterday's fried eggs — so I think they're literally still parked in my gut. That pushed me to two choices. First, Tesa is off until my BF% drops again, because I suspect much of this weight is water plus food just sitting there. Nicotine remained at 14 mg.

Lunch was a strange sensation. Part of me was hungry, but a small amount of food made me full. Sure, I could have shoved more in — I chose not to. I also skipped pinning Cagri that day. The plotter says I've currently got 355 mcg of Cagri on board, so I'll hold off 2 more days before the next 250 mcg shot. Good news: today tiredness was almost absent.

18:00 — Correction needed. Around 6 PM the exhaustion landed. Zero motivation. Complete apathy. I'd say full Grumpy Mode kicked in. I scraped together whatever energy remained and took my dogs for a walk.

23:00 — Lying in bed, hunger is back. It feels more physical than mental. And yes, I clearly under-ate today — this day will close with a huge deficit.

24.08.2026 — The day began with a drive to the country house to tend my animals, nicotine at 14 mg as always. Firewood again after that. On the drive home around 10 AM, hunger returned. Not food noise — physical hunger, stomach growling included. Breakfast at home: three eggs and a sausage. Then extreme tiredness hit, so I went to bed and slept like a baby from about 11 AM until 1 PM.

Lunch came around 3 PM, but I could only manage a little — some baked salmon and a carnivore tuna cake, half of which went to my dog. After that small meal, the hunger was gone.

 

[Kyli]

Cagri trial comes to a close

25.08.2026 — Nothing out of the ordinary occurred.

26.08.2026 — A regular day as well, though one event stood out. During a conversation with my mom, she questioned me directly — had I quit taking some of my substances? Her reasoning: I'm no longer as relaxed, and I've become clearly more aggressive.

Something else only clicked for me later on: driving home from my animals, a weird feeling came over me. A mild pressure beneath my right rib cage. Back then, I brushed it off as the lanyard flopping around in that area.

27.08.2026 — This day was unremarkable too. Things appeared to have returned to baseline, and I even believed the drowsiness and exhaustion from Cagri had mostly lifted. Then, while sitting at my desk working, an odd sensation hit me. Describing it properly is hard — it felt as though my organs were dropping downward, similar to a sack of dog food. Sitting there any longer was unappealing; standing while working felt preferable.

28.08.2026 — That feeling on the right side, below the ribs, persisted, and genuine worry set in. Following a chat with the All-Knowing Tin Can, the likely culprit became clear: the gallbladder. Stomach emptying isn't the only thing Reta + Cagri slow down — the gallbladder gets slowed too. The result can be thickened bile or even stones.

Given all this, my time with Cagri ends here. Reta stays in the picture, but Cagri is done for now.

 

[boomstar]

Appreciate you posting about how it went for you. I'd been considering stacking Cagri with my reta, but after reading this I'll probably wait.