Mots-c injection site reactions persist despite switching to Hospira bac

restingbeachface

restingbeachface

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I came across a thread mentioning that saline bac water works with some peptides, mots-c included. Has anyone tried that approach and ended up with almost no ISR? Curious too about other spicy peps such as GHK-Cu. I've used Hospira bac and mots-c is the only one that has ever given me ISR. During my previous round with mots-c and vendor bac, the ISRs were horrendous, so I picked up some Hospira and this time started with KPV and SS-31. The ISR is less severe but it's still showing up.
 
Per Jay Campbell's site, KPV is described as more of an "insurance" measure for spicy peptides (a post-injection treatment) than something as critical as dilution or even Benadryl cream.

I did add KPV (reconstituted with saline BAC) into a GHK-Cu syringe. It looked like it helped, though GHK-Cu never gave me much in the way of ISRs to begin with.

And naturally, many people abandon MOTS-c, and there's good reason for that. I've got a kit set aside for experimenting next year or beyond. I'm holding out for someone to come up with a better approach, assuming one exists for native MOTS-c.

Going full broscience here: perhaps TA1 might help indirectly, and glutathione too. Just keep adding more peptides, haha.
 
Calm Logic said:

Per Jay Campbell's site, KPV is described as more of an "insurance" measure for spicy peptides (a post-injection treatment) than something as critical as dilution or even Benadryl cream.

I did add KPV (reconstituted with saline BAC) into a GHK-Cu syringe. It looked like it helped, though GHK-Cu never gave me much in the way of ISRs to begin with.

And naturally, many people abandon MOTS-c, and there's good reason for that. I've got a kit set aside for experimenting next year or beyond. I'm holding out for someone to come up with a better approach, assuming one exists for native MOTS-c.

Going full broscience here: perhaps TA1 might help indirectly, and glutathione too. Just keep adding more peptides, haha.
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I only began this last night. I reconstituted both with saline BAC as well. This morning there was one very small red bump, but it has since disappeared. It was slightly tender this morning too. I have two questions: do you use separate syringes, or do you draw both into a single one? And where are you injecting? Apologies to the OP for the hijack.
 
BNLFL said:

I only began this last night. I reconstituted both with saline BAC as well. This morning there was one very small red bump, but it has since disappeared. It was slightly tender this morning too. I have two questions: do you use separate syringes, or do you draw both into a single one? And where are you injecting? Apologies to the OP for the hijack.
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I put both into one syringe — KPV went in first, followed by GHK-Cu. Whether priming the spot with KPV beforehand would help is something I can't say.
 
Has anyone observed a real difference in ISR when using saline BAC compared with non-saline BAC? Given the small volumes usually injected, I doubt there would be much of a difference.

I have simply assumed that the advice came from someone who picked up the concept of osmotic pressure in college and was attempting to offer an educated guess about it.
 
tubby said:

Has anyone observed a real difference in ISR when using saline BAC compared with non-saline BAC? Given the small volumes usually injected, I doubt there would be much of a difference.

I have simply assumed that the advice came from someone who picked up the concept of osmotic pressure in college and was attempting to offer an educated guess about it.
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It provides some relief, though with MOTS-c there is a limit to how much it can accomplish.
 
It may be best to stop using it altogether, since allergic reactions often get worse over time. Mots-c has been known to trigger anaphylactic shock, which calls for immediate medical attention.
 
If you have insurance coverage, you might be able to obtain an EpiPen, a generic version, or the Neffy spray at no cost. Neffy also offers a free trial process that you can go through on their website.
 
An EpiPen only buys you time — you should still reach a hospital before the pen's effects fade, unless you happen to be lucky and the reaction is mild. In that case you might gamble on skipping medical care, but gamble is the operative word.
 
I'd be curious to hear who has run MOTS-c for the longest stretch.

Youarewhen said:

An EpiPen only buys you time — you should still reach a hospital before the pen's effects fade, unless you happen to be lucky and the reaction is mild. In that case you might gamble on skipping medical care, but gamble is the operative word.
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Honestly, if I lived by myself I wouldn't touch MOTS-c at all, and IM is completely off the table for me. The "Epi Pen Resources" thread has more details too.

That said, I haven't come across any reported deaths, which isn't the case with CJC. That doesn't prove it never happened. The worst case would be an asthmatic using it, or someone doing an IM shot right before bed.
 
BNLFL said:

I only began this last night. I reconstituted both with saline BAC as well. This morning there was one very small red bump, but it has since disappeared. It was slightly tender this morning too. I have two questions: do you use separate syringes, or do you draw both into a single one? And where are you injecting? Apologies to the OP for the hijack.
Click to expand...

With a single syringe, pull the KPV first, then the GHK-Cu. I've experimented with injecting in various spots, but LadyJ's suggestion to pin it in the butt was the best. That approach has served me well. The sting is gone now, and I no longer get welts.
 
restingbeachface said:

I came across a thread mentioning that saline bac water works with some peptides, mots-c included. Has anyone tried that approach and ended up with almost no ISR? Curious too about other spicy peps such as GHK-Cu. I've used Hospira bac and mots-c is the only one that has ever given me ISR. During my previous round with mots-c and vendor bac, the ISRs were horrendous, so I picked up some Hospira and this time started with KPV and SS-31. The ISR is less severe but it's still showing up.
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That same information came up in the NaCl BAC thread, so I gave it a try. Sadly, my MOTS-C turned cloudy after a day or two with the saline BAC. It's disappointing, since it genuinely appeared to reduce the spicyness. Just so you know: with the first cartridge that went cloudy, I only spotted it after I'd finished it and pulled the cart out of the pen — I'd assumed the haze was just condensation on the outside of the cart. Apart from the spice of the shot, I had no problems at all, health or SE wise.

The second time it went cloudy, though, I was watching for it, and I threw it out. For me, there's no point in being reckless. I've also since picked up an adrenaline kit from Goodies (search their site for "In case of emergency" ~$25 USD, and they don't ship outside the USA).
 
BNLFL said:

I only began this last night. I reconstituted both with saline BAC as well. This morning there was one very small red bump, but it has since disappeared. It was slightly tender this morning too. I have two questions: do you use separate syringes, or do you draw both into a single one? And where are you injecting? Apologies to the OP for the hijack.
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It's totally fine! This is a solid question, and we're all here to learn from one another.
 
HouseCat said:

That same information came up in the NaCl BAC thread, so I gave it a try. Sadly, my MOTS-C turned cloudy after a day or two with the saline BAC. It's disappointing, since it genuinely appeared to reduce the spicyness. Just so you know: with the first cartridge that went cloudy, I only spotted it after I'd finished it and pulled the cart out of the pen — I'd assumed the haze was just condensation on the outside of the cart. Apart from the spice of the shot, I had no problems at all, health or SE wise.

The second time it went cloudy, though, I was watching for it, and I threw it out. For me, there's no point in being reckless. I've also since picked up an adrenaline kit from Goodies (search their site for "In case of emergency" ~$25 USD, and they don't ship outside the USA).
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That's a shame! I'd have thrown it out as well — better safe than sorry. Good to know about the adrenaline kit. I'll look into that. Thanks.
 
Wakesetter5477 said:

With a single syringe, pull the KPV first, then the GHK-Cu. I've experimented with injecting in various spots, but LadyJ's suggestion to pin it in the butt was the best. That approach has served me well. The sting is gone now, and I no longer get welts.
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Yesterday I tried this with mots-c. I drew KPV and then mots into one syringe. There was some itchiness yesterday, though no welt appeared. Today, however, there's an itchy welt on my butt cheek 😭😆
 
This isn't really about mots-c; it's about injecting in general.

Nearly everyone seems to favor the shortest, thinnest needle they can get. Insulin is very gentle on the layer of skin it goes into. Not every subcutaneous injection is that gentle.

Give that some thought. Matching needle depth to the specific medication is important.

I don't have definitive answers, but when something is irritating the skin, the first thing I wonder is: "Could that needle be too short?"
 
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