Me Vs Gout

[RetaRX]

Current score is Gout 1087544 : Me 0.

It’s been about 7 years since my first attack and it has been getting worse progressively. For reference I’m 45.

What started as one or two attacks a year has become an attack every 6-8 weeks.

Colchicine has been helping but it’s very taxing on my stomach and kidneys. Usually takes 4-7 days for the drug to assist.

I’m not ready to get on Allopurinol due to long term damage to liver and kidneys which leads me to this point in time.

I plan on testing every know peptide that may help in battling gout attacks and preventing attacks. I won’t stack just yet, I’m interested to find out which peptide provides the most assistance individually. If and when I find something that works, I’ll probably stack them but until then, Let The Testing Begin!

Current stack

Reta 1 mg every 4 days

Tesa 1mg sun-thur

First up - KPV

Protocol length - 8 weeks starting from first sign of attack

Frequency - daily AM

Week 1 - 200mcg

Week 2 - 300mcg

Week 3 - 400mcg

Week 4-8 - 500mcg

Gout flare up identified late night on 20/06, right foot, big toe.

Pep Start date: 21/06/2026

KPV + Colchicine

21/06/2026

No immediate changes to pain and inflammation

22/06/2026

Significant reduction in pain and inflamation

23/06/2026

Pain and inflammation reduced to almost zero.

Could be incidental but I’ve never had an attack clear in 2 days. Another thing I noticed after starting KPV, injection site irritation and bruising caused by Tesamorelin seems to be clearing up much quicker.

I’ll keep reporting with any significant updates.

PS. I’m nursing Plantar Fasciitis in the same foot and it’s been going on 6 weeks now. Significant pain reduction and increased mobility observed. Once again, could be incidental.

 

[Skidude]

RetaRX said:


Current score is Gout 1087544 : Me 0.

Click to expand...

I have heard others benefit from glp1s and gout mitigation

So might be 1087544 : You 1.

 

[RetaRX]

Funnily enough, the most likely reason for the current attack is rapid weight loss.

At this stage I’m calling this one a draw that strangely feels like a win.

 

[Chili777]

GLPs and KPV work. More experiences and info here:




Peps for Gout



My husband gets the absolute worst gout flare ups. Like absolutely crippling. He works with doctors...does the best he cab with diet control but it still happens and puts him out of commission. We have been dabbling in peptide land for a bit now but haven't expanded beyond weight management...

GLP1Chat.com




Four letter word, Gout



Start off with my love for the pride of Golden Colorado and also food adorned in corn meal and baptized in oil. Got a lot of that sorted with Reta. My doctor gave me a piece of paper allowing me to procure allopurinol (sp.?) a number of years ago and it’s a miracle drug. Flash forward 3 years...

GLP1Chat.com

And there are other threads

 

[RetCurious]

RetaRX said:


I’m not ready to get on Allopurinol due to long term damage to liver and kidneys

Click to expand...

You may want to reassess your understanding of Allopurinol. My understanding is there are no indications that it causes long term damage to liver and kidneys apart from rare cases of preexisting conditions and is quite safe so long as it's use is monitored by your physician.

That being said I've been on it for around 15 years, it's been a god send. I'd suffered several attacks each worse than the last. The last attack, pre-Allopurinol, was so bad a sheet touching my foot felt like a blow torch. Post Allopurinol I have not had another attack.

 

[RetaRX]

RetCurious said:


You may want to reassess your understanding of Allopurinol. My understanding is there are no indications that it causes long term damage to liver and kidneys apart from rare cases of preexisting conditions and is quite safe so long as it's use is monitored by your physician.

That being said I've been on it for around 15 years, it's been a god send. I'd suffered several attacks each worse than the last. The last attack, pre-Allopurinol, was so bad a sheet touching my foot felt like a blow torch. Post Allopurinol I have not had another attack.

Click to expand...

I’m not taking anything away from allopurinol and the benefits users get from it.

My preference at this stage is to work on finding ways to eliminate gout through better diet, exercise and inflammation reduction.

I’m recording my own experience testing different solutions. That’s all.

 

[RetaRX]

Chili777 said:


GLPs and KPV work. More experiences and info here:




Peps for Gout



My husband gets the absolute worst gout flare ups. Like absolutely crippling. He works with doctors...does the best he cab with diet control but it still happens and puts him out of commission. We have been dabbling in peptide land for a bit now but haven't expanded beyond weight management...

GLP1Chat.com




Four letter word, Gout



Start off with my love for the pride of Golden Colorado and also food adorned in corn meal and baptized in oil. Got a lot of that sorted with Reta. My doctor gave me a piece of paper allowing me to procure allopurinol (sp.?) a number of years ago and it’s a miracle drug. Flash forward 3 years...

GLP1Chat.com

And there are other threads

Click to expand...

Thanks for sharing those, I had a look at them before posting. None had long term reporting on use and outcomes so I figured I’ll be my own Guinea pig and record my results publicly.

I hope someone finds it useful.

 

[RetCurious]

RetaRX said:


I’m not taking anything away from allopurinol and the benefits users get from it.

Click to expand...

You stated:

RetaRX said:


I’m not ready to get on Allopurinol due to long term damage to liver and kidneys

Click to expand...

Which struck me as misinformation that might deter someone from getting the help they need.

If I misread I apologize.

 

[Chili777]

RetaRX said:


Thanks for sharing those, I had a look at them before posting. None had long term reporting on use and outcomes so I figured I’ll be my own Guinea pig and record my results publicly.

I hope someone finds it useful.

Click to expand...

Over 9 months on Reta and I haven't had a flare that hasn't been handled by a few ibuprofen since I started.

 

[Chili777]

RetCurious said:


You stated:

Which struck me as misinformation that might deter someone from getting the help they need.

If I misread I apologize.

Click to expand...

Yeah, Allopurinol doesn't cause kidney problems. I was on it for over 15 years and my kidney function tests came back perfect. It was also nearly useless for me too, and Uloric finally did work.

 

[QueenMuntha]

@RetaRX you are not understanding what Gout is doing to your body. A flare is just the tip of the iceberg. Even when you are not having a flare, the crystals are damaging your systems and may eventually cripple you. The crystals themselves damage your kidneys, joints and other organs--SILENTLY. Thank goodness that the flares exist to alert you to the high urates in your system.

Allopurinol has been used for decades and is safe for most. Asians do have problems with Allo, and are usually prescribed Febuxostat instead. Allopurinol is processed through the kidneys and liver, causing some patients to worry about long-term damage. In reality, uncontrolled gout and high uric acid are far more damaging to kidney function. Your doctor will typically run regular blood tests to ensure your dosage is safe and your organs are handling the medication well.

Treating the individual attacks is different from treating the disease. Please reconsider and get some more information.

I used to have constant attacks. Now, five years of daily 200 mg of Allo has my numbers below 5 and no attack in years, REGARDLESS of what I eat. AND, my Chronic Kidney Disease is improving with the GLP-1 use with continued Allo.

 

[Chili777]

It's also important to note that recent research has shown that gout is largely hereditary and diet alone is not sufficient to control it. I spent years avoiding purine-laden foods and it made little difference to me.

Massive Study Reveals Where Gout Comes From, And It's Not What We Thought



Gout is often blamed on overindulgence in alcohol or unhealthy eating, but research suggests genetics plays a much bigger role in the painful arthritic condition than previously thought.

www.sciencealert.com

 

[Mochizuki0124]

As someone who has gout. The main thing is knowing your triggers. You can lose weight with Reta but if you keep eating your triggers, YOU WILL STILL HAVE GOUT. im fairly lean and I had a gout flare up just coz I ate one of my triggers.

1 thing that I can say though and there's no science behind this so dont quote me on it. I had the gout on my foot and I injected my KLOW on that same side of the leg. My gout was gone in about 2.5 days (with 1 tablets of colchicine) when usually my attacks are 4-6 days.

Mind you I dont take allo coz im allergic to it but just by managing my triggers I probably get an attack once a year.

 

[ColdSmoke]

Take the damn Allopurinol.

 

[lessthanhalf]

I am just going to agree with some of the above posts. There are 2 reasons that high blood levels of uric acid are a problem. One is gout, the other is the damage the high uric acid levels do over time to many different organs. High uric acid is an independent risk factor for cardiovascular disease, so leaving it untreated raises your risks of heart attack. It is also a risk for renal disease, and the damage done to joints both during acute attacks and in between is likely to be permanent and irreversible.

I am not sure why you are reluctant to use allopurinol ( or other uric acid lowering drugs ). The simple fact is they have been proven to work to prevent attacks of gout and to prevent damage to other organs, this is not the case for any of the peptides. At best assuming they work as advertised and this is somewhat doubtful, they might reduce acute inflammation , but will not help with the chronic tissue damage from high uric acid levels.

You might be able to get levels down a bit with diet, but it is unlikely to make enough of a difference to prevent gout or prevent the damage the high uric acid levels do. You should also have blood pressure, lipids, blood sugars, urine protein etc checked as you have one extra cardiac risk factor and that means you should get the others checked as well if not done already

Colchicine is still sometimes used for acute gout but it was going out of fashion for that 30 plus years ago, fairly high dose non steroidal anti inflammatory drugs would be used more often and may offer faster relief, but get a medical opinion.

 

[eidos]

Febuxostat worked really well for me in lowering my uric acid levels. My levels were very high, and I had some pain in my big toe that was still bearable, but nothing like the attacks you’re experiencing. My levels were twice the upper limit, and they dropped to half the threshold in 8 months. I didn’t experience any side effects, although at the time I had a heart electrical problem.

GLP-1 agonists are pretty miraculous for all sorts of unexpected things. When I started Reta, I had sensations similar to when my uric acid was high, but that went away. Since the blood test was the previous month, I don't know yet if the levels have changed. Maybe Reta will help after a while, time will tell.

You're currently on the maintenance dose for KPV; you can increase it to 2 x 500 μg per day. The only problem is that if you have an infection, it can mask it or make it last longer (I have chronic pityriasis that's lingering well beyond its usual time frame).

 

[Chili777]

eidos said:


Febuxostat worked really well for me in lowering my uric acid levels. My levels were very high, and I had some pain in my big toe that was still bearable, but nothing like the attacks you’re experiencing. My levels were twice the upper limit, and they dropped to half the threshold in 8 months. I didn’t experience any side effects, although at the time I had a heart electrical problem.

GLP-1 agonists are pretty miraculous for all sorts of unexpected things. When I started Reta, I had sensations similar to when my uric acid was high, but that went away. Since the blood test was the previous month, I don't know yet if the levels have changed. Maybe Reta will help after a while, time will tell.

You're currently on the maintenance dose for KPV; you can increase it to 2 x 500 μg per day. The only problem is that if you have an infection, it can mask it or make it last longer (I have chronic pityriasis that's lingering well beyond its usual time frame).

Click to expand...

The same thing happened to me when I started Reta. For the first couple weeks, I was thinking, "Here we go again", and I was concerned that I might have to stop. But, I had some Prednisone available so I decided to keep going to see if it would get worse or not. I was thrilled when it just went away after those first two weeks. It's been clear sailing since.

 

[eidos]

That's what I love about this forum. We're able to get information that doctors and clinical studies have never observed. It's really a great addition to experimental methods and complementary to them.

It reminds me of reflexivity, which has long been seen as a problem in sociology: the fact that the subject/object of study can reflect on and understand the study and change its behavior. It's a real problem that humans aren't just passive rats in a cage.(/s)

Action research has overcome this problem by involving participants in the study. I see it emerging here, and it's pretty magical.

 

[RetaRX]

I appreciate everyone’s input. I’m not trying to tell people to not take allo, I’m simply expressing my choice and reasoning.

My wording around long term damage wasn’t the best. I didn’t mean long term usage caused liver and kidney disease, I meant it can cause long term damage. Is it rare? Yes.

I’ve resigned to the fact that if all else fails I will get on Allo or equivalent.

For the time being I’ll give you updates whilst on this adventure

 

[QueenMuntha]

Mochizuki0124 said:


As someone who has gout. The main thing is knowing your triggers. You can lose weight with Reta but if you keep eating your triggers, YOU WILL STILL HAVE GOUT. im fairly lean and I had a gout flare up just coz I ate one of my triggers.

1 thing that I can say though and there's no science behind this so dont quote me on it. I had the gout on my foot and I injected my KLOW on that same side of the leg. My gout was gone in about 2.5 days (with 1 tablets of colchicine) when usually my attacks are 4-6 days.

Mind you I dont take allo coz im allergic to it but just by managing my triggers I probably get an attack once a year.

Click to expand...

Gout does not go away. You may have paused the attacks, but the crystals from gout are always there chipping away at your joints and organs. You can control it, but not eliminate it.

The 4 Stages of Gout Progression (and How to Stop Gout from Getting Worse)



Learn more about the stages of gout, how gout progresses, and how to prevent gout from getting worse.

creakyjoints.org