Looking for Input on Adding Another Medication

[casons1miracle]

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

 

[Redz]

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

 

[BBA1969]

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Could you tell us what doses you're on, and about how much weight needs to come off?

 

[BNLFL]

^^^That is exactly what he said. For us, this feels like moving forward without any guidance.

 

[cheaperseeker]

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

 

[BBA1969]

It really comes down to the reason it was prescribed and whether any titration took place. If 0.5mg was the ceiling you reached and that happens to be the lowest therapeutic dose, then you are in fact sitting at a low maintenance dose.

 

[Vash]

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

What are the doses? How many calories are you taking in, and what does your macro split look like?

 

[DrPEPr]

Vash said:

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

What are the doses? How many calories are you taking in, and what does your macro split look like?

This

How does the diet look?

 

[Devilseye]

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

As everyone else mentioned, post your dosing details. My suggestion would be to include a solid 15mg of tirz and stop using reta. When it comes to managing hunger, tirz simply outperforms, so I'd hold off on reta—either adding it or switching to it—unless you hit a plateau with tirz. Another reason I lean toward tirz as the starting point is that reta tends to be hard on the heart, lowering HRV and raising HR. Pairing tirz with sema ought to crush your appetite and get you past that plateau. Best of luck!

 

[Devilseye]

And cragri shouldn’t even be on your radar. Sure, it works well for hunger in the beginning, but tolerance builds fast. I gave it a shot, then stopped, and neither my weight nor my appetite shifted at all. Elora is still way too pricey IMO, and tirz/sema ought to get you solid results—so hit a plateau on those first before you even consider elora.

 

[miameow]

Like the others have said, knowing what doses you were on before and what you're taking now for each compound would really help. If the hunger is still that intense, maybe the dose isn't high enough, or perhaps reta just isn't the right fit for you—at least not by itself.

I get that some folks say you shouldn't expect reta to carry the whole load, but it ought to make things smoother, not tougher.

Honestly, if willpower alone could do it, why would any of us be on GLP-1s?

 

[Devilseye]

Reta's affinity for GLP1 is weak, so it usually doesn't suppress appetite very well—certainly not to the degree tirz does. When it comes to reta, the dramatic weight reduction is mainly driven by GIP/GCGR.

 

[Redz]

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

 

[miameow]

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

 

[Redz]

miameow said:

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

Given that, my position doesn’t change: this post depends on medication. You’re free to disagree, but that’s my read. Physical activity can definitely assist in managing your body in various ways. Switching to foods that keep you satiated, for instance, is another point worth raising. Your perspective treats drugs as the only route, which is acceptable, yet it isn’t the best path for either health or outcomes.

 

[BBA1969]

Knowing the dosages and current BMI would probably clarify nearly all of this. No weight loss after 8 months of Semaglutide? Only 3lbs lost over 3 months on Retatrutide...?

 

[PurpleSage]

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Could you explain what "my rs" refers to? What person or thing does that stand for? Is it you, or are you talking about somebody else?

 

[lastresort]

If your calorie balance is net zero, then neither tirzepatide nor semaglutide will be effective.

Could you please describe what you eat?

 

[miameow]

Redz said:

miameow said:

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

Given that, my position doesn’t change: this post depends on medication. You’re free to disagree, but that’s my read. Physical activity can definitely assist in managing your body in various ways. Switching to foods that keep you satiated, for instance, is another point worth raising. Your perspective treats drugs as the only route, which is acceptable, yet it isn’t the best path for either health or outcomes.

There isn't enough here for you to draw that conclusion. While others are requesting additional background, you're characterizing the OP as a person who depends solely on medication and puts in zero effort. In a support community, that's neither fair nor appropriate.

Redz said:

miameow said:

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

Given that, my position doesn’t change: this post depends on medication. You’re free to disagree, but that’s my read. Physical activity can definitely assist in managing your body in various ways. Switching to foods that keep you satiated, for instance, is another point worth raising. Your perspective treats drugs as the only route, which is acceptable, yet it isn’t the best path for either health or outcomes.

The original question concerned managing severe hunger. In what way does inquiring about someone's exercise habits provide an answer to that? You mentioned that exercise helps regulate the body in multiple ways, so I'm taking that to mean appetite.

Redz said:

miameow said:

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

Given that, my position doesn’t change: this post depends on medication. You’re free to disagree, but that’s my read. Physical activity can definitely assist in managing your body in various ways. Switching to foods that keep you satiated, for instance, is another point worth raising. Your perspective treats drugs as the only route, which is acceptable, yet it isn’t the best path for either health or outcomes.

miameow said:

Redz said:

cheaperseeker said:

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Extreme hunger came up. Regardless of whether an exercise routine is in place, the medication isn't performing the way it ought to.

I get how it could look like that person just wants meds to handle everything while putting in nothing else.

Nope, that isn't true at all.

casons1miracle said:

My rs spent roughly a year on Ozempic. During the first 4 months, 20 pounds came off, then for the following 8 months there was no change at all. About 3 months ago, rs began reta, and since then rs has dropped 3 pounds. Evening hunger is still very strong, so I have been considering whether to add cagri or tirz. Which of those would work better? Thanks.

Where exactly is the evidence of zero effort? Someone who genuinely did nothing would not have dropped any weight. Telling a person who has already shed 23 lbs, hit a plateau, and come here looking for guidance that they put in no work is simply not fair.

Redz said:

It seems like a more comprehensive approach would be beneficial. From what I gather, you're expecting the medications to handle everything. Have you incorporated any exercise routine into this?

Genuine question: in what way does exercise fix intense hunger?

Honestly, these medications are designed to carry much of the load. That is precisely the goal, and the reason the GLP-1 market is growing so fast: they make losing weight less difficult.

What I said was that the drugs ought to handle a lot of the work — not all(=drug only) of it. Those two claims are not remotely the same.

 

[Redz]

I believe this is getting out of hand. I didn't mean to offend anyone—my only aim is to assist in ways that are healthy. Aside from the first weight loss, having such disappointing outcomes points to a serious issue that isn't being tackled.