Leg swelling while on reta?

[sunnygirl]

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

 

[CNCCurrency]

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

That's odd — in the group I'm part of, everyone on it saw their inflammation decrease.

 

[SoCalGirl]

With a calorie deficit, are you moving less? Lymph flow tends to improve when you stay active.

 

[Rosco P. Coltrane]

Yep! A few days back, I saw my legs had puffed up a bit, which hadn't happened before. I stay quite active and spend 10-12 hours daily on my feet. I'm not ready to blame the reta just yet. I'll test a few approaches to try and identify the trigger.

 

[sunnygirl]

CNCCurrency said:

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

That's odd — in the group I'm part of, everyone on it saw their inflammation decrease.

Since there is no inflammation in my case, the swelling in my feet is something new

 

[sunnygirl]

Rosco P. Coltrane said:

Yep! A few days back, I saw my legs had puffed up a bit, which hadn't happened before. I stay quite active and spend 10-12 hours daily on my feet. I'm not ready to blame the reta just yet. I'll test a few approaches to try and identify the trigger.

We'd really appreciate an update from you!

 

[CNCCurrency]

sunnygirl said:

CNCCurrency said:

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

That's odd — in the group I'm part of, everyone on it saw their inflammation decrease.

Since there is no inflammation in my case, the swelling in my feet is something new

I'm not sure I understand? Isn't swelling the same as inflammation?

 

[sunnygirl]

SoCalGirl said:

With a calorie deficit, are you moving less? Lymph flow tends to improve when you stay active.

Since beginning reta, my routine has stayed unchanged. To find out whether it makes a difference, I'll aim to fit in extra walks.

 

[sunnygirl]

CNCCurrency said:

sunnygirl said:

CNCCurrency said:

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

That's odd — in the group I'm part of, everyone on it saw their inflammation decrease.

Since there is no inflammation in my case, the swelling in my feet is something new

I'm not sure I understand? Isn't swelling the same as inflammation?

Apologies. What I meant is that prior to using reta, swelling in my legs or feet was never an issue for me. So this is a new development. Whether it ties back to reta, I really can't say

 

[CNCCurrency]

sunnygirl said:

CNCCurrency said:

sunnygirl said:

CNCCurrency said:

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

That's odd — in the group I'm part of, everyone on it saw their inflammation decrease.

Since there is no inflammation in my case, the swelling in my feet is something new

I'm not sure I understand? Isn't swelling the same as inflammation?

Apologies. What I meant is that prior to using reta, swelling in my legs or feet was never an issue for me. So this is a new development. Whether it ties back to reta, I really can't say

Got it.

 

[lessthanhalf]

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

Ankle or foot puffiness isn't something that's been reported as a side effect, and at such a small dose it's unlikely to have much of an impact. I'd question whether it's connected at all. Whether to seek a doctor's input could depend on how old you are and your general state of health. Women tend to experience it more often, as do people with varicose veins, older individuals, and those who stand for long stretches at work—but some of the possible causes are more serious than others.

 

[Hambocommando]

My feet and ankles swell up quite a bit when my allergies act up. Since I'm allergic to basically everything in my area — naturally — it flares up and then settles down. Could that be what's going on?

 

[TooBigtoFail]

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

 

[CNCCurrency]

TooBigtoFail said:

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

Wait, what? A hearth is the area around my fireplace.

 

[MortalM]

Is this actually reta, though? That sounds like edema to me, but edema tends to show up with GH secretagogues. Just lately, testing has revealed some vials were mislabeled.

 

[woundcarping]

TooBigtoFail said:

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

Would you be willing to share what happened with the NAION? Yours is the first account I’ve come across from someone who actually went through it.

 

[jaynedough570]

sunnygirl said:

Since beginning retatrutide at 0.5 mg, I've seen a bit more puffiness in my feet. It's not something that worries me much, but socks that previously never left indentations around my ankles are now pressing in more deeply than they did before.

When I went hunting for details on leg edema with GLP-1 drugs, the results felt all over the place. A few places claim this isn't a typical adverse effect, whereas others state that it can occur.

Anyone else dealing with puffiness, or currently having swollen feet or legs while on retatrutide?

Have you been getting enough food and activity? Back when I struggled with an eating disorder, my legs became quite swollen because of poor nutrition and because I wasn't moving much, since my energy was so low.

 

[TooBigtoFail]

woundcarping said:

TooBigtoFail said:

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

Would you be willing to share what happened with the NAION? Yours is the first account I’ve come across from someone who actually went through it.

On the NAION topic: I had been using Tirz for a year and had dropped 60# when, out of nowhere, vision in my left eye vanished. The lower half of my field of view turned blank — as if someone raised a curtain — and it lasted roughly 4-5 minutes. I was outdoors at the time, soldering some wires. There was nothing else going on. My eye doctor diagnosed it as NAION and advised me to quit Tirz (I didn't). She said this was a recognized adverse effect. Apart from still carrying 50# of extra weight, I had no other conditions. When I looked through medical journals, what I found was that 'a definitive causal link has not been established'. Since GLP1 use is tracked and reported so heavily, it's simple to assign blame. In my view, the more likely explanation is fast weight loss, dehydration, rather than the glp1 itself. These days I'm down 104#, retired, and healthier than I was at 25. My hunch is that doctors are protecting themselves.... Every 4-5 months I get nutritional blood tests, and nothing comes back off except mildly elevated Ketones, which makes sense since I prioritize protein intake.

 

[woundcarping]

TooBigtoFail said:

woundcarping said:

TooBigtoFail said:

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

Would you be willing to share what happened with the NAION? Yours is the first account I’ve come across from someone who actually went through it.

On the NAION topic: I had been using Tirz for a year and had dropped 60# when, out of nowhere, vision in my left eye vanished. The lower half of my field of view turned blank — as if someone raised a curtain — and it lasted roughly 4-5 minutes. I was outdoors at the time, soldering some wires. There was nothing else going on. My eye doctor diagnosed it as NAION and advised me to quit Tirz (I didn't). She said this was a recognized adverse effect. Apart from still carrying 50# of extra weight, I had no other conditions. When I looked through medical journals, what I found was that 'a definitive causal link has not been established'. Since GLP1 use is tracked and reported so heavily, it's simple to assign blame. In my view, the more likely explanation is fast weight loss, dehydration, rather than the glp1 itself. These days I'm down 104#, retired, and healthier than I was at 25. My hunch is that doctors are protecting themselves.... Every 4-5 months I get nutritional blood tests, and nothing comes back off except mildly elevated Ketones, which makes sense since I prioritize protein intake.

How did the NAION ultimately resolve in your case?

Would you be able to go into more detail about the nutritional blood panels?

 

[TooBigtoFail]

woundcarping said:

TooBigtoFail said:

woundcarping said:

TooBigtoFail said:

I haven't had any swelling. What happens with swelling is that blood collects in the tissue near the ankles — it isn't drawn upward by a fireplace. Look up what can cause it. On a GLP1 you should be taking in more fluids. Could the blood be thicker than normal? Go get a medical evaluation. The issues that showed up for me over the last 2 years (dry eyes, NAION, kidney stones, and so on) might just come with aging. I can't show that any of them came from glp1. Read about the ABI test, which checks the Ankle Brachial Index, to compare blood pressure readings at your ankles versus your arms.

Would you be willing to share what happened with the NAION? Yours is the first account I’ve come across from someone who actually went through it.

On the NAION topic: I had been using Tirz for a year and had dropped 60# when, out of nowhere, vision in my left eye vanished. The lower half of my field of view turned blank — as if someone raised a curtain — and it lasted roughly 4-5 minutes. I was outdoors at the time, soldering some wires. There was nothing else going on. My eye doctor diagnosed it as NAION and advised me to quit Tirz (I didn't). She said this was a recognized adverse effect. Apart from still carrying 50# of extra weight, I had no other conditions. When I looked through medical journals, what I found was that 'a definitive causal link has not been established'. Since GLP1 use is tracked and reported so heavily, it's simple to assign blame. In my view, the more likely explanation is fast weight loss, dehydration, rather than the glp1 itself. These days I'm down 104#, retired, and healthier than I was at 25. My hunch is that doctors are protecting themselves.... Every 4-5 months I get nutritional blood tests, and nothing comes back off except mildly elevated Ketones, which makes sense since I prioritize protein intake.

How did the NAION ultimately resolve in your case?

Would you be able to go into more detail about the nutritional blood panels?

My eyesight returned within 4-5 minutes. The doctor said I was fortunate because it might have lasted forever. Quest offers standard cmp/cbc panels, lipid tests, and more, including thyroid indicators (TSH, T3, and T4), nutritional markers (ferritin, vitamin D, vitamin B12, and folate), plus other tests you can ask for. Physicians typically order only 1, or at most 2, of these panels annually. I order extra on my own.