Just appetite suppression, or something more like with GLP-1s?

jafarrr61020

jafarrr61020

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I have read that elora has more appetite suppression than our current big 3 (sema, tirz, reta) and I've been looking for explicit info about whether that's the only effect that leads to weight loss, or does it have other metabolism effects that also contribute, like glp-1s do?

I'm a tirz user who's had some success but side effects have kept me at medium doses despite averaging only 0.5 lb loss a week overall, lower now in month eight. I'm excited about elora particularly because of its HR reduction side effect, as my main tirz side effect is a big boost in HR that makes sleep and exercise tough. However, further appetite suppression isn't something I need, and I'm looking forward to learning more about elora's mechanism of action. Has anyone seen this addressed in the literature? I'd love a link, thank you!
 
jafarrr61020 said:


I have read that elora has more appetite suppression than our current big 3 (sema, tirz, reta) and I've been looking for explicit info about whether that's the only effect that leads to weight loss, or does it have other metabolism effects that also contribute, like glp-1s do?

I'm a tirz user who's had some success but side effects have kept me at medium doses despite averaging only 0.5 lb loss a week overall, lower now in month eight. I'm excited about elora particularly because of its HR reduction side effect, as my main tirz side effect is a big boost in HR that makes sleep and exercise tough. However, further appetite suppression isn't something I need, and I'm looking forward to learning more about elora's mechanism of action. Has anyone seen this addressed in the literature? I'd love a link, thank you!

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Based on everything that's publicly available...hardly much so far, appetite suppression appears to be the primary driver of the weight loss. I haven't seen any published evidence that elora independently increases energy expenditure or has the broad metabolic effects we see with GLP-1 agonists.

The reductions in heart rate and blood pressure are definitely interesting, but those don't necessarily translate into increased metabolismin fact, they could suggest the opposite.
 
Scorpio73 said:


The reductions in heart rate and blood pressure are definitely interesting, but those don't necessarily translate into increased metabolismin fact, they could suggest the opposite.

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I had the same thought, it's counterintuitive at best. It'll be interesting to see what develops; seems like we'll be hearing a LOT more about it since the incredible trial results
 
I’ve been wondering about this myself. If the benefits of amylin agonists were solely appetite suppression, then why have I been so excited about eloralintide? I could have just used semaglutide, which already significantly suppresses my appetite, and called it a day.

Based on what I’ve read, however, amylin agonists may do more than simply suppress appetite. Amylin signaling interacts with central leptin pathways and, at least in animal studies, may partially restore leptin responsiveness.

People with ordinary obesity generally have plenty of circulating leptin because leptin is produced by fat tissue. The problem is that the brain may become less responsive to leptin’s signal regarding the body’s longer-term energy stores.

In theory, this means amylin agonists might influence the body’s regulation or “defense” of body weight, not just how hungry someone feels. You could loosely connect that with weight set point theory, although that remains debated.

It is still far too early to say that eloralintide can reset anyone’s weight set point or that its weight-loss effects in humans are meaningfully driven by improved leptin sensitivity. But that possibility is part of why I find amylin agonists so interesting.
 
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