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ryanfreebush

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Hey everyone on the forum,

I'm a guy in my late 30s. For roughly 10 years I've dealt with binge eating — and I mean genuinely absurd quantities of food eaten in one sitting. About 3 months back I finally saw a nutritional psychiatrist, who put me on compounded tirzepatide. At that stage I had basically run out of options and honestly figured it wouldn't do anything. My starting dose was 2 mg, then after a few weeks I went to 4 mg, and in the end I got up to 10 mg. The result was, frankly, amazing: for 10 weeks my bingeing disappeared entirely. Dieting and training felt effortless in a way I hadn't felt for years.

Then, near the close of that 10-week stretch, I binged for 3 days straight. "Expert ChatGPT" suggested the cause was my body fat having fallen to roughly 11–12%, meaning my body was fighting back aggressively despite tirzepatide's GLP-1/GIP activity. During those final weeks of dieting my sleep collapsed (cortisol spikes, supposedly), and the hunger and food noise returned at full force, close to how things were before I ever touched the medication. Apparently that's expected when body fat gets low, even while on these drugs.

After that binge I was crushed. So I did something irrational (and probably irresponsible): I raised my tirzepatide from 10 mg to 13.5 mg. Within 24 hours of that jump, though, I felt like I was back at the start — food noise roughly 75% lower, mood improved, everything more settled. Do I believe that chasing a bigger dose for a particular effect is a wise long-term plan? No. I'm trying to work out how to move ahead without simply putting a GLP-1 band-aid over something deeper.

Some extra background: I'm also on TRT via a urology clinic. And in something of a panic after the binge, I ordered additional testosterone, tirzepatide, and semaglutide from a reputable peptide seller. Lately I've been very curious about GLP-1s, particularly stacking them (though the reviews are mixed). The entire reason I wanted to "shred" over these past 10 weeks was to be able to begin a testosterone cycle and add muscle cleanly, rather than starting from a higher body fat level and having to deal with estrogen problems.

Anyway, I'm glad to be here and I'm looking forward to browsing around.
 
"ordered more testosterone, tirzepatide, and semaglutide"...what's the reason for using tirz and sema together? Tirz alone should be enough. Following the dosing schedule, reaching 12.5mg on tirz takes 5 months. You seem to be around 11-12 weeks in? That's just my 2 cents, but I wouldn't continue raising the dose. You'll hit the ceiling. What are you aiming for? Is more weight loss the goal? Or do you just want to maintain and silence the food noise? Other peptides might assist with that (I'll leave it to others to chime in, since tirz has been sufficient in my case). I'm not on trt, but from what I understand it can boost appetite? People here might have better input, but I'm curious whether the trt is dulling or working against the tirz? Before tirz, my food noise was awful. The weekly dose didn't work for me since the food noise came back by day 5, so I switched to split dosing.
 
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