INTRO Slow loser but not giving up! Ozempic to Tirz to Reta

[kittenfeet]

Bonjour, greetings from Canada!

I've spent 3 years on glps (ozempic for 1 year, mounjaro for 1.5 years, and reta for 0.5 years). So far I've dropped 70 pounds, which works out to a bit more than 20 pounds each year. It hasn't been easy, particularly when shortages of ozempic and mounjaro hit for a few months. After that, I started birth control and put on weight, so I quit it fast because I didn't lose weight only to put it all back on haha. Women's hormones sure can be a pain!

Right now I'm taking 10mg of reta (5mg twice weekly), but I've been stuck for nearly 2 months. Since I was on 15mg of mounjaro for almost a year, I realize I'll need a bigger dose of reta.

Has anyone else needed a high dose of reta before it truly kicked in? I see folks dropping 10 pounds a month on just 2mgs lol. I try not to compare since every body is different, and I don't mind the slow weight loss because I have no loose skin. Still, I'd like to lose 50 more pounds and I really don't want it to take another 2 years...

I'm still hungry on reta, so I'm considering lowering to maybe 8mgs and adding 2-4mg of tirz since it suppresses appetite better.

If anyone has used higher doses of reta (10mg+) or combined it with tirz, I'd love to hear how it's going for you! I'm very grateful to have lost 70 pounds, but I feel like I haven't found the magic dose that works for me yet. People always say that once you find your magic dose on reta, the weight just melts off like butter and the hunger stops, but I feel like I haven't found it yet!

 

[dancs]

Hello and welcome! I'm also new around here! I can see how tough this has been for you, and I really don't want you to feel stuck or, even worse, like you're slipping back into old habits. A lot of people don't know this and even assume it works against you, but the truth is you can use Tirz AND reta together. What most folks miss is that Tirz is actually quite a bit stronger for suppressing hunger and shutting down food noise/cravings, and it gives you the sense that you're more in charge of when you eat, how much you eat, and your own self-control. Reta, on the other hand, supports more fat loss and less muscle loss while keeping you fuller for longer. If you're on 10mg of reta and it's been some time since your last Tirz use, my suggestion would be to restart Tirz at 5mg weekly and titrate up if it seems like your body has become desensitized to it.

This is the most effective way.

That said, if taking 2 GLP's makes you uneasy for whatever reason, other peptides exist that you could use, such as AOD-9604 and MOTS-C. My suggestion would be to look up both of those on Google Gemini or ChatGPT so you can better understand what they are, what they do for you, and the protocol/dosage (Swolverine is pretty consistent regarding the dosing/protocol).

Beyond that, my suggestion would be to begin going to the gym and lifting heavy weights with proper form, and to try not to eat too much processed foods while drinking ample amounts of water/fluids.

I wish you good luck on your endeavor and if you need help with anything, I'm certain this community will be able to help you!

 

[msyntakz]

Hi, and welcome! It looks like I'm among those who react quite strongly to these meds, since 2.5mg Tirz worked well for me during month 1. Still, I wanted what Reta offers too, while keeping the food noise quiet. So I introduced 1mg Reta. Food noise suppression clearly went up, and the amount I could eat in one sitting went down.

My approach: push Reta up to at least a therapeutic dose, while leaving Tirz in the background at the lowest amount that still keeps food noise down. That's the reason I began with Tirz. I NEEDED my mind to be quiet.

So even though our total mg differ, I think a combo along the lines you're describing can work. If you're aiming for 10mg total with an 80/20 Reta/Tirz ratio, which raises your GLP/GIP agonism, that seems like a sensible place to start.

 

[hodlplus]

Hello! I'm fairly new around here too. GLP1s haven't made me a hyper-responder either. They've made a huge difference for me, Tirz in particular, but since last July it's taken me to drop 60 lbs. Not as slow as your pace, but I have relatives and friends who shed 20lbs within 1.5 months, and that's definitely not what I've experienced. I've also noticed that on GLP1s I need to be really precise with my diet and maintain a very obvious, clear caloric deficit to lose weight. Still, it's much easier while on a GLP1.

I'm curious how the tirz and reta combo works out for you, since I'm thinking about doing the same!

 

[JG_VZA]

I take 2mg tirzepatide alongside 2mg retatrutide, every other day. That’s a fairly hefty dose, and it’s been performing really well up to now. I needed to make a change once I hit a bit of a plateau.

 

[ravii]

I'd like to know whether there are any known reasons why certain individuals shed pounds at a slower pace than others. I realize these medications aren't a miracle solution and that adjustments in habits could still be necessary. I'm wondering if any of you have pinpointed anything like that.

I'm still at the pre-start stage and I'm trying to figure out what I'll need to be ready to dedicate myself to in order for this to succeed.

 

[Svartr]

Another person in the slow-responder club here

MJ was my medication for 12 months, but once the cost climbed I stopped, and by then I had dropped a bit more than 30kg. Now I'm using Tirz again and honestly the progress is extremely gradual. About 2 weeks back I added MOTs, and at last there's been a small movement; small as it is, I'm accepting it

A hashimoto's diagnosis just came my way — my TSH went from 4.17 to 7.25 mIU/L over the course of 1 year, so my guess is that plus perimenopause is playing a part in how slowly I'm losing. I also have a suspicion that lipedema might be involved.

I'm thinking about adding reta at low doses together with tirz to see whether that moves things forward, but I'd really like to hear from others dealing with lipedema and hashimoto's who have managed some success. I'm pleased with what I've lost so far, yet I'd love to shed another 20 - 25 kg.

 

[kittenfeet]

dancs said:

Hello and welcome! I'm also new around here! I can see how tough this has been for you, and I really don't want you to feel stuck or, even worse, like you're slipping back into old habits. A lot of people don't know this and even assume it works against you, but the truth is you can use Tirz AND reta together. What most folks miss is that Tirz is actually quite a bit stronger for suppressing hunger and shutting down food noise/cravings, and it gives you the sense that you're more in charge of when you eat, how much you eat, and your own self-control. Reta, on the other hand, supports more fat loss and less muscle loss while keeping you fuller for longer. If you're on 10mg of reta and it's been some time since your last Tirz use, my suggestion would be to restart Tirz at 5mg weekly and titrate up if it seems like your body has become desensitized to it.

This is the most effective way.

That said, if taking 2 GLP's makes you uneasy for whatever reason, other peptides exist that you could use, such as AOD-9604 and MOTS-C. My suggestion would be to look up both of those on Google Gemini or ChatGPT so you can better understand what they are, what they do for you, and the protocol/dosage (Swolverine is pretty consistent regarding the dosing/protocol).

Beyond that, my suggestion would be to begin going to the gym and lifting heavy weights with proper form, and to try not to eat too much processed foods while drinking ample amounts of water/fluids.

I wish you good luck on your endeavor and if you need help with anything, I'm certain this community will be able to help you!

Thanks for the encouragement, it really means a lot! This past week I switched things up: my reta dose is now 5mg, plus I added 2.5mg tirz. I'll stick with this for a while and skip taking another 5mg reta dose, which means I won't hit the 10mg total I was on previously. Curious to find out whether tirz can bring my appetite down!

MOTS-C is something I've come across before, but AOD is totally new to me! I'll do some research on it. Appreciate the suggestions

 

[kittenfeet]

msyntakz said:

Hi, and welcome! It looks like I'm among those who react quite strongly to these meds, since 2.5mg Tirz worked well for me during month 1. Still, I wanted what Reta offers too, while keeping the food noise quiet. So I introduced 1mg Reta. Food noise suppression clearly went up, and the amount I could eat in one sitting went down.

My approach: push Reta up to at least a therapeutic dose, while leaving Tirz in the background at the lowest amount that still keeps food noise down. That's the reason I began with Tirz. I NEEDED my mind to be quiet.

So even though our total mg differ, I think a combo along the lines you're describing can work. If you're aiming for 10mg total with an 80/20 Reta/Tirz ratio, which raises your GLP/GIP agonism, that seems like a sensible place to start.

It's great that such a small dose is doing the job for you with reta and tirz! (imagine a grumpy face here). haha, only joking! Seriously though, seeing others stack reta with tirz and get results makes me feel better about it. After going through these comments, I went back to 2.5 tirz this past week for my first dose, so we'll find out whether the scale budges a little What you said about needing to calm your mind really resonates, and tirz seems to help more with that. Wishing you the best on your journey!

 

[kittenfeet]

hodlplus said:

Hello! I'm fairly new around here too. GLP1s haven't made me a hyper-responder either. They've made a huge difference for me, Tirz in particular, but since last July it's taken me to drop 60 lbs. Not as slow as your pace, but I have relatives and friends who shed 20lbs within 1.5 months, and that's definitely not what I've experienced. I've also noticed that on GLP1s I need to be really precise with my diet and maintain a very obvious, clear caloric deficit to lose weight. Still, it's much easier while on a GLP1.

I'm curious how the tirz and reta combo works out for you, since I'm thinking about doing the same!

Losing 60 pounds since last July is fantastic! That's something you should feel really good about. I've added tirz to my reta routine, so we'll see what happens over the coming weeks. Fingers crossed the number on the scale moves at least a bit! A handful of folks in this community have said they combine the two, and I've come across plenty of people on reddit saying the same. So if progress has flatlined for you, it might be something to look into

 

[QueenMuntha]

Svartr said:

Another person in the slow-responder club here

MJ was my medication for 12 months, but once the cost climbed I stopped, and by then I had dropped a bit more than 30kg. Now I'm using Tirz again and honestly the progress is extremely gradual. About 2 weeks back I added MOTs, and at last there's been a small movement; small as it is, I'm accepting it

A hashimoto's diagnosis just came my way — my TSH went from 4.17 to 7.25 mIU/L over the course of 1 year, so my guess is that plus perimenopause is playing a part in how slowly I'm losing. I also have a suspicion that lipedema might be involved.

I'm thinking about adding reta at low doses together with tirz to see whether that moves things forward, but I'd really like to hear from others dealing with lipedema and hashimoto's who have managed some success. I'm pleased with what I've lost so far, yet I'd love to shed another 20 - 25 kg.

That's me too. Lipedema plus a touch of Hashimotos. A full year on GLP1s and I've only dropped 60 pounds, despite still having more than 150 pounds left to lose. Even with my carbs being very low lately, a 2 pound monthly loss feels like a win. My path went Sema first, then Tirz, then Tirz combined with Reta, and finally back to Tirz alone. The pace refuses to pick up no matter what.

So I'm in the same boat, hunting for another compound to add on top of Tirz and finally get this moving.

 

[dancs]

QueenMuntha said:

Svartr said:

Another person in the slow-responder club here

MJ was my medication for 12 months, but once the cost climbed I stopped, and by then I had dropped a bit more than 30kg. Now I'm using Tirz again and honestly the progress is extremely gradual. About 2 weeks back I added MOTs, and at last there's been a small movement; small as it is, I'm accepting it

A hashimoto's diagnosis just came my way — my TSH went from 4.17 to 7.25 mIU/L over the course of 1 year, so my guess is that plus perimenopause is playing a part in how slowly I'm losing. I also have a suspicion that lipedema might be involved.

I'm thinking about adding reta at low doses together with tirz to see whether that moves things forward, but I'd really like to hear from others dealing with lipedema and hashimoto's who have managed some success. I'm pleased with what I've lost so far, yet I'd love to shed another 20 - 25 kg.

That's me too. Lipedema plus a touch of Hashimotos. A full year on GLP1s and I've only dropped 60 pounds, despite still having more than 150 pounds left to lose. Even with my carbs being very low lately, a 2 pound monthly loss feels like a win. My path went Sema first, then Tirz, then Tirz combined with Reta, and finally back to Tirz alone. The pace refuses to pick up no matter what.

So I'm in the same boat, hunting for another compound to add on top of Tirz and finally get this moving.

AOD-9604, MOTS-c, 5-Amino-1mq, SLU-PP-332, Cagrilintide, and Tesamorelin are among the other peps that may assist with weight loss....

My suggestion is that you look into the compounds listed above. Tesamorelin stands out as somewhat unexpected, though it does cut down visceral fat. As for SLU-PP-332, no genuine peer-reviewed work exists on it as of now. It leans more toward being an experimental drug, essentially an "exercise in a pill". Theoretically, it makes your mind believe it is continuously exercising, which leads to burning more calories over the course of the day.

Taking every one of those simultaneously is not something I'd advise, but once more, put in your own due diligence and determine what suits you best!

When it comes to this, these forums along with STG are the best route!