INTRO Rémi in Paris

[m12s]

My reason for being here is to learn about peptides for my brother, who has diabetes and a BMI of 34.

Diabetes will likely affect me as well in about 15 years. To put that off, I want to find ways to avoid weight gain and the start of insulin resistance.

I swim often, but cruralgia means I run less.

At the university of technology I took a few chemistry courses, but peptides are completely new to me.

In everyday life I don't go by Rémi; that's one of my other given names.

 

[m12s]

Several years back, I held a sysadmin position at an eye clinic. A number of the nurses and lab techs I used to work with are still people I run into.

To pick up how to dilute peptides and how to inject them, what ought I be asking these people?

Some posts have been read and some videos watched on my end, but what I really need is a person to demonstrate it face to face.

 

[m12s]

While browsing Peppedia, I came across a write-up on MOTS-c, a peptide, and one of the pieces there covers insulin resistance.

A passage from what they summarized reads:

Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide

Click to expand...

named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novopurine biosynthesis, leading to AMPK activation [...]

A lot of these terms go over my head

Could you check if my takeaway is correct?

• My understanding is that this motsc peptide works against insulin resistance.
  
• For it to actually do anything, is a high-fat diet required, the way the experiment did it?
  
• If insulin resistance hasn't developed yet but diabetes risk is high, would it still be useful?
  
• Has anyone here used it under those circumstances?
  
• What dosage would you suggest in my case?

(I'm totally confused. Some posts show people using it daily, others just 3 times per week, and a few run it for several weeks and then pause.)

 

[BBA1969]

m12s said:

While browsing Peppedia, I came across a write-up on MOTS-c, a peptide, and one of the pieces there covers insulin resistance.

A passage from what they summarized reads:

Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide

Click to expand...

named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novopurine biosynthesis, leading to AMPK activation [...]

A lot of these terms go over my head

Could you check if my takeaway is correct?

• My understanding is that this motsc peptide works against insulin resistance.
  
• For it to actually do anything, is a high-fat diet required, the way the experiment did it?
  
• If insulin resistance hasn't developed yet but diabetes risk is high, would it still be useful?
  
• Has anyone here used it under those circumstances?
  
• What dosage would you suggest in my case?

(I'm totally confused. Some posts show people using it daily, others just 3 times per week, and a few run it for several weeks and then pause.)

Glad you made it here. Whatever you're wondering about, chances are this community already has the answers — so settle in, browse around, and pick things up at your own pace. One pointer: the search button is your friend.

Should weight be the core problem, my advice is to begin with GLPs. The two that have been available longest and have the strongest body of research behind them are Semaglutide and Tirzepatide, while Retatrutide is fairly new yet looks very promising.

Once that's sorted, other compounds can be layered in later. Keep in mind that no peptide works overnight. Healthy living has to be the foundation. A disastrous lifestyle can't be undone by any peptide, but they do give you a big push toward making the right choises.

Best of luck to both you and your brother.

 

[m12s]

I’ve looked through this forum already, plus that chaotic place known as Reddit (their AI search tool can be useful at times).

Right now my issue is MOTS-c: the dosage and duration info I keep running into contradicts itself.

What’s your method for making sense of it?

Evidence or documentation is missing from most of what I find.

It brings to mind a line from a French humorist about "a guy’s" final words: “You can come take a swim, I’m sure it’s dolphins.”

Thanks for any help.

 

[Chris13]

m12s said:

I’ve looked through this forum already, plus that chaotic place known as Reddit (their AI search tool can be useful at times).

Right now my issue is MOTS-c: the dosage and duration info I keep running into contradicts itself.

What’s your method for making sense of it?

Evidence or documentation is missing from most of what I find.

It brings to mind a line from a French humorist about "a guy’s" final words: “You can come take a swim, I’m sure it’s dolphins.”

Thanks for any help.

Welcome!

If your main concern is staying healthy and managing type 2 diabetes, then GLP-1 medications deserve most of your attention. They carry approvals for both type 2 diabetes and weight loss, and they outperform Mots-C and other options by a wide margin.

As for Mots-C, research is still ongoing and the bulk of the evidence comes from animal studies. Even then, it works more like a "cerise sur le gateau" once the fundamentals are in place (training, diet, GLP-1, etc.), so there's no reason to stress about it at this stage.

TL;DR: Begin with a GLP-1 (Tirzepatide or Retatrutide, for instance), keep track of health markers for both you and your brother (blood glucose, Hb1ac), then reevaluate. No need to bother with Mots-C yet.

 

[m12s]

Appreciate it — I'll begin with Reta and check what results come from it.

Chris13 said:

m12s said:

I’ve looked through this forum already, plus that chaotic place known as Reddit (their AI search tool can be useful at times).

Right now my issue is MOTS-c: the dosage and duration info I keep running into contradicts itself.

What’s your method for making sense of it?

Evidence or documentation is missing from most of what I find.

It brings to mind a line from a French humorist about "a guy’s" final words: “You can come take a swim, I’m sure it’s dolphins.”

Thanks for any help.

Welcome!

If your main concern is staying healthy and managing type 2 diabetes, then GLP-1 medications deserve most of your attention. They carry approvals for both type 2 diabetes and weight loss, and they outperform Mots-C and other options by a wide margin.

As for Mots-C, research is still ongoing and the bulk of the evidence comes from animal studies. Even then, it works more like a "cerise sur le gateau" once the fundamentals are in place (training, diet, GLP-1, etc.), so there's no reason to stress about it at this stage.

TL;DR: Begin with a GLP-1 (Tirzepatide or Retatrutide, for instance), keep track of health markers for both you and your brother (blood glucose, Hb1ac), then reevaluate. No need to bother with Mots-C yet.