INTRO My Journey: 80kg Lost with Mounjaro and Switching to Retatrutide

[oioioi]

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

 

[Spork]

Wow - what an achievement on your weight loss!

Since you've gone from tirzepatide over to retatrutide, what's the appetite suppression like now? We often hear anecdotally from folks who've made that same change, and they report the suppression isn't as strong with retatrutide - did you find that too?

 

[hosseinzadeh]

That's really amazing! You should definitely feel proud of what you've accomplished.

I'm still new to peptides, so I'm here to learn and read everything I can before making my first purchase.

 

[oioioi]

Spork said:

Wow - what an achievement on your weight loss!

Since you've gone from tirzepatide over to retatrutide, what's the appetite suppression like now? We often hear anecdotally from folks who've made that same change, and they report the suppression isn't as strong with retatrutide - did you find that too?

At 15 mg of MJ, suppression has completely stopped for me, which is why I'm making the change. Reta hasn't been started yet — that begins next week. Should Reta prove completely ineffective (my plan is to stay on it for a minimum of 3 month), I'll do a "reset": quit every medication for a few month, then begin again from scratch (MJ included).

 

[UgottaBkiddingMe]

You shed close to 50% of your starting body weight!! That's amazing!!

Same as you, I stayed on tirzep until I reached a "normal" weight. Then I moved to reta for maintenance, drawn by the stories about it protecting muscle and offering perks beyond tirzep. I'm just at week 6.

Remembering that no two bodies are alike and each can respond, or potentially respond, in its own way to anything put into it, this is what I've noticed for myself so far at week 6, after going from 5mg of tirzep every 7 days to 2.5 of reta every 7 days:

- food noise has come back, no question, more than with tirzep, though it's somewhat muted. If that tracks. Before tirzep, it was blaring and unmistakable - 75-level tv volume. On tirzep, it vanished for a year. Perhaps at a clear, yet far lower 25 level tv volume after 1 year. On reta so far, it sits at 40, but muffled, not so crystal clear. A bit easier to tune out than an unmedicated 40.

- could be all in my head or entirely tied to other factors but, I feel a bit more…. Blah? With slightly less energy but a noticeable drop in motivation. I've seen elsewhere that others have gone through this too. Really hoping this fades. So far, not a deal breaker. But, for me, not sustainable long-term.

- again, could be from other factors (I have narcolepsy and I might be nearing or in perimenopause) but, my sleep has been pretty rough. Easily awoken, light sleep, up after 2-3 hours and hard to get back to sleep.

- my skin is super sensitive. Like a body-wide skin ache with some spots feeling a bit sunburned. I wouldn't call it painful, more uncomfortable (2/10 pain if I had to rate it). I've also seen that others go through this too but it fades after a time.

I'm hoping to stay at a low dose (preferably 2.5mg/week or even lower) and might take a 2-3 month break down the road to see if that helps.

Congrats again! And best of luck on your continued journey!

 

[CornPop]

Nice work dropping that weight! If tirz stops working for me, I may give the same approach a shot, though I'll deal with it at that point. Was it your medical team that recommended Reta, if I understood you correctly?

 

[RETAinJP?]

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

I've begun moving over from triz to Reta, and honestly it doesn't seem to be working as well as triz did for me.

 

[oioioi]

RETAinJP? said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

I've begun moving over from triz to Reta, and honestly it doesn't seem to be working as well as triz did for me.

So my approach is to combine them. As I mentioned, right now I'm on 15 mg of Mounjaro. Once I begin Reta, my plan is 2 mg Reta plus 13 mg MJ, then adjust from there. I've come across several accounts saying Reta doesn't suppress appetite as strongly as MJ, but by stacking them I might cover that gap and still gain what each offers. According to what I've seen posted in this forum, Reta works better when the dose goes above 5 mg. That suggests a reasonable combo could be 10 mg MJ with 5 mg Reta. Still, I'll raise the Reta gradually because I don't know how my body will respond. At 15 mg MJ I've had no issues, yet I won't experiment carelessly with something that has such a long half-life. Slow and steady is the way I'll go.

 

[oioioi]

CornPop said:

Nice work dropping that weight! If tirz stops working for me, I may give the same approach a shot, though I'll deal with it at that point. Was it your medical team that recommended Reta, if I understood you correctly?

Thanks. No, it wasn't advised. I talked it over, but I'll be upfront with my Dr. and let him know after I've begun it.

 

[oioioi]

UgottaBkiddingMe said:

You shed close to 50% of your starting body weight!! That's amazing!!

Same as you, I stayed on tirzep until I reached a "normal" weight. Then I moved to reta for maintenance, drawn by the stories about it protecting muscle and offering perks beyond tirzep. I'm just at week 6.

Remembering that no two bodies are alike and each can respond, or potentially respond, in its own way to anything put into it, this is what I've noticed for myself so far at week 6, after going from 5mg of tirzep every 7 days to 2.5 of reta every 7 days:

- food noise has come back, no question, more than with tirzep, though it's somewhat muted. If that tracks. Before tirzep, it was blaring and unmistakable - 75-level tv volume. On tirzep, it vanished for a year. Perhaps at a clear, yet far lower 25 level tv volume after 1 year. On reta so far, it sits at 40, but muffled, not so crystal clear. A bit easier to tune out than an unmedicated 40.

- could be all in my head or entirely tied to other factors but, I feel a bit more…. Blah? With slightly less energy but a noticeable drop in motivation. I've seen elsewhere that others have gone through this too. Really hoping this fades. So far, not a deal breaker. But, for me, not sustainable long-term.

- again, could be from other factors (I have narcolepsy and I might be nearing or in perimenopause) but, my sleep has been pretty rough. Easily awoken, light sleep, up after 2-3 hours and hard to get back to sleep.

- my skin is super sensitive. Like a body-wide skin ache with some spots feeling a bit sunburned. I wouldn't call it painful, more uncomfortable (2/10 pain if I had to rate it). I've also seen that others go through this too but it fades after a time.

I'm hoping to stay at a low dose (preferably 2.5mg/week or even lower) and might take a 2-3 month break down the road to see if that helps.

Congrats again! And best of luck on your continued journey!

Thanks for laying out your experience in such detail! And well done on everything you've achieved

As I mentioned, dropping a few more KG is still my goal, so a higher dose will likely be necessary for that to happen. That's especially true given how long I've been on MJ at this point. On top of that, the improving weather should let me get back to more garden work, which ought to make a real difference.

 

[grandmaincrocs]

Normally I'd stick with something that's already doing the job, but I get how frustrating a plateau can feel, so good luck. Also really glad you've got a medical team behind you rather than just improvising!

 

[RETAinJP?]

oioioi said:

RETAinJP? said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

I've begun moving over from triz to Reta, and honestly it doesn't seem to be working as well as triz did for me.

So my approach is to combine them. As I mentioned, right now I'm on 15 mg of Mounjaro. Once I begin Reta, my plan is 2 mg Reta plus 13 mg MJ, then adjust from there. I've come across several accounts saying Reta doesn't suppress appetite as strongly as MJ, but by stacking them I might cover that gap and still gain what each offers. According to what I've seen posted in this forum, Reta works better when the dose goes above 5 mg. That suggests a reasonable combo could be 10 mg MJ with 5 mg Reta. Still, I'll raise the Reta gradually because I don't know how my body will respond. At 15 mg MJ I've had no issues, yet I won't experiment carelessly with something that has such a long half-life. Slow and steady is the way I'll go.

Should you not have started it so far, my suggestion would be to bring the dosages in your stack down. Compared with tirz, the satiation and physical hunger I experience while on Reta are more intense. What I notice is that the mental aspect tirz provides seems largely absent with Reta. Even at 2mg of Reta it remains quite potent for me, though I'm beginning to suspect that what drew me to Manjouro was mainly the reduction in food noise. Then again, maybe I'm simply sensitive to GLP peptides overall. The effectiveness of 2.5 mg triz never truly seemed to fade for me.

 

[UgottaBkiddingMe]

oioioi said:

UgottaBkiddingMe said:

You shed close to 50% of your starting body weight!! That's amazing!!

Same as you, I stayed on tirzep until I reached a "normal" weight. Then I moved to reta for maintenance, drawn by the stories about it protecting muscle and offering perks beyond tirzep. I'm just at week 6.

Remembering that no two bodies are alike and each can respond, or potentially respond, in its own way to anything put into it, this is what I've noticed for myself so far at week 6, after going from 5mg of tirzep every 7 days to 2.5 of reta every 7 days:

- food noise has come back, no question, more than with tirzep, though it's somewhat muted. If that tracks. Before tirzep, it was blaring and unmistakable - 75-level tv volume. On tirzep, it vanished for a year. Perhaps at a clear, yet far lower 25 level tv volume after 1 year. On reta so far, it sits at 40, but muffled, not so crystal clear. A bit easier to tune out than an unmedicated 40.

- could be all in my head or entirely tied to other factors but, I feel a bit more…. Blah? With slightly less energy but a noticeable drop in motivation. I've seen elsewhere that others have gone through this too. Really hoping this fades. So far, not a deal breaker. But, for me, not sustainable long-term.

- again, could be from other factors (I have narcolepsy and I might be nearing or in perimenopause) but, my sleep has been pretty rough. Easily awoken, light sleep, up after 2-3 hours and hard to get back to sleep.

- my skin is super sensitive. Like a body-wide skin ache with some spots feeling a bit sunburned. I wouldn't call it painful, more uncomfortable (2/10 pain if I had to rate it). I've also seen that others go through this too but it fades after a time.

I'm hoping to stay at a low dose (preferably 2.5mg/week or even lower) and might take a 2-3 month break down the road to see if that helps.

Congrats again! And best of luck on your continued journey!

Thanks for laying out your experience in such detail! And well done on everything you've achieved

As I mentioned, dropping a few more KG is still my goal, so a higher dose will likely be necessary for that to happen. That's especially true given how long I've been on MJ at this point. On top of that, the improving weather should let me get back to more garden work, which ought to make a real difference.

Same here!! On weekend days in summer, I'm typically outside in my yard(s) for 8+ hours/day, and 2-3 on weekdays once work is done. I sweat like a hog as well - my joke is that I'm dropping my built-in winter coat

 

[decimusmaximus7]

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

Semaglutide gave me nothing over 6 months, so I moved directly to reta. Only at 6mg did reta begin to have an effect for me. I went up to 12mg and reached 10% body fat. To add some bulk back, I lowered it to 10mg, but in the end I changed to tirzepetide for maintenance attempts: my heart rate stayed elevated the whole time I was on reta even with nebivolol prescribed, the cost was slightly lower, and my wife uses Tirz. I increased Tirz to 15mg, gained roughly 12 pounds, which I think I needed, and I have held that steady for 3 months. Still, on reta I had far less food noise and felt better overall. My plan is to go back to reta now and find a maintenance dose that stops further loss, while I try Diltiazem for heart rate.

If anyone has any better suggestions, I am open to them.

 

[oioioi]

decimusmaximus7 said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

Semaglutide gave me nothing over 6 months, so I moved directly to reta. Only at 6mg did reta begin to have an effect for me. I went up to 12mg and reached 10% body fat. To add some bulk back, I lowered it to 10mg, but in the end I changed to tirzepetide for maintenance attempts: my heart rate stayed elevated the whole time I was on reta even with nebivolol prescribed, the cost was slightly lower, and my wife uses Tirz. I increased Tirz to 15mg, gained roughly 12 pounds, which I think I needed, and I have held that steady for 3 months. Still, on reta I had far less food noise and felt better overall. My plan is to go back to reta now and find a maintenance dose that stops further loss, while I try Diltiazem for heart rate.

If anyone has any better suggestions, I am open to them.

On MJ my pulse went up roughly 5-10 bpm. Before any GLPs my RHR sat at 55 bpm, and these days it reads 60-65 bpm. It hasn't dropped back since. My mother had the same pattern: once she quit, her RHR returned to where it started. I'm sure the identical thing would happen to me if I ever stop MJ or Reta. As for Sema, it gives me nothing at all, apart from triggering the worst (and first) panic attack I've had in years! I never went near it again.

My body fat is at 20%, and I want to reach 15%.

Regarding blood pressure and bringing the RHR down: "fermented black garlic" might be useful for you. I've never used it, since my blood pressure sometimes runs low (sys. 100 mmHg). So if your blood pressure is already normal or low, I wouldn't suggest taking it. Still, you could give it a try, and it's certainly far better than any drug you'd take, given that it's natural.

 

[oioioi]

RETAinJP? said:

oioioi said:

RETAinJP? said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

I've begun moving over from triz to Reta, and honestly it doesn't seem to be working as well as triz did for me.

So my approach is to combine them. As I mentioned, right now I'm on 15 mg of Mounjaro. Once I begin Reta, my plan is 2 mg Reta plus 13 mg MJ, then adjust from there. I've come across several accounts saying Reta doesn't suppress appetite as strongly as MJ, but by stacking them I might cover that gap and still gain what each offers. According to what I've seen posted in this forum, Reta works better when the dose goes above 5 mg. That suggests a reasonable combo could be 10 mg MJ with 5 mg Reta. Still, I'll raise the Reta gradually because I don't know how my body will respond. At 15 mg MJ I've had no issues, yet I won't experiment carelessly with something that has such a long half-life. Slow and steady is the way I'll go.

Should you not have started it so far, my suggestion would be to bring the dosages in your stack down. Compared with tirz, the satiation and physical hunger I experience while on Reta are more intense. What I notice is that the mental aspect tirz provides seems largely absent with Reta. Even at 2mg of Reta it remains quite potent for me, though I'm beginning to suspect that what drew me to Manjouro was mainly the reduction in food noise. Then again, maybe I'm simply sensitive to GLP peptides overall. The effectiveness of 2.5 mg triz never truly seemed to fade for me.

Lowering the MJ dose is something I'll attempt, yeah. Today marked my first 2 mg Reta shot. My last MJ injection was 15 mg, 2 days back. Next time I might reduce it. It all comes down to how I feel overall.

 

[DrPEPr]

De

oioioi said:

RETAinJP? said:

oioioi said:

RETAinJP? said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

I've begun moving over from triz to Reta, and honestly it doesn't seem to be working as well as triz did for me.

So my approach is to combine them. As I mentioned, right now I'm on 15 mg of Mounjaro. Once I begin Reta, my plan is 2 mg Reta plus 13 mg MJ, then adjust from there. I've come across several accounts saying Reta doesn't suppress appetite as strongly as MJ, but by stacking them I might cover that gap and still gain what each offers. According to what I've seen posted in this forum, Reta works better when the dose goes above 5 mg. That suggests a reasonable combo could be 10 mg MJ with 5 mg Reta. Still, I'll raise the Reta gradually because I don't know how my body will respond. At 15 mg MJ I've had no issues, yet I won't experiment carelessly with something that has such a long half-life. Slow and steady is the way I'll go.

Should you not have started it so far, my suggestion would be to bring the dosages in your stack down. Compared with tirz, the satiation and physical hunger I experience while on Reta are more intense. What I notice is that the mental aspect tirz provides seems largely absent with Reta. Even at 2mg of Reta it remains quite potent for me, though I'm beginning to suspect that what drew me to Manjouro was mainly the reduction in food noise. Then again, maybe I'm simply sensitive to GLP peptides overall. The effectiveness of 2.5 mg triz never truly seemed to fade for me.

Lowering the MJ dose is something I'll attempt, yeah. Today marked my first 2 mg Reta shot. My last MJ injection was 15 mg, 2 days back. Next time I might reduce it. It all comes down to how I feel overall.

What you're describing might be receptor desensitization.

With these glp1, gip, glucagon agonists, the way they work is by attaching to their matching receptors and turning them on. It's comparable to something like cocaïne acting on the serotonine, norepinepherine and dopamine receptors — over time you require increasingly larger amounts, since the receptors get over-stimulated and the drug loses potency.

Taking a lower dose from time to time can produce remarkable results.

Dropping 80Kg, by the way, is seriously impressive! You rock!

 

[decimusmaximus7]

oioioi said:

decimusmaximus7 said:

oioioi said:

Hey all! I've just joined this GLP1Chat after reading quietly for some time, and I figured it was finally time to tell my story. Maybe it'll motivate somebody, or at least get a good conversation going.

My journey began close to 2 years back, when I weighed roughly 175kg and felt utterly lost and trapped. I'd cycled through so many diets and workout routines without lasting success, until my doctor put me on Mounjaro (tirzepatide) because of diabetes. That changed everything! With my appetite under control and my energy levels stable, I could finally stick to better food choices and increase my activity. Roughly 10 months later, I'd dropped an incredible 80kg – now sitting at 95kg, a normal weight. It's like I've become someone else: far more self-assured, in better health, and actually enjoying daily life instead of fighting it.

Still, progress has stalled lately, so after talking it over with my healthcare team, I'm making the change to retatrutide. It's still being tested, but the early data suggests it might work even better, particularly for people whose progress has stalled on other GLP-1/GIP medications. I'm roughly a month in and already seeing things move again – and the side effects have been lighter than I'd braced for. I'll share more as things develop!

I'd really like to hear from anyone who's done a similar swap, or who has advice for handling the switch. Thanks for being such a welcoming community!

Semaglutide gave me nothing over 6 months, so I moved directly to reta. Only at 6mg did reta begin to have an effect for me. I went up to 12mg and reached 10% body fat. To add some bulk back, I lowered it to 10mg, but in the end I changed to tirzepetide for maintenance attempts: my heart rate stayed elevated the whole time I was on reta even with nebivolol prescribed, the cost was slightly lower, and my wife uses Tirz. I increased Tirz to 15mg, gained roughly 12 pounds, which I think I needed, and I have held that steady for 3 months. Still, on reta I had far less food noise and felt better overall. My plan is to go back to reta now and find a maintenance dose that stops further loss, while I try Diltiazem for heart rate.

If anyone has any better suggestions, I am open to them.

On MJ my pulse went up roughly 5-10 bpm. Before any GLPs my RHR sat at 55 bpm, and these days it reads 60-65 bpm. It hasn't dropped back since. My mother had the same pattern: once she quit, her RHR returned to where it started. I'm sure the identical thing would happen to me if I ever stop MJ or Reta. As for Sema, it gives me nothing at all, apart from triggering the worst (and first) panic attack I've had in years! I never went near it again.

My body fat is at 20%, and I want to reach 15%.

Regarding blood pressure and bringing the RHR down: "fermented black garlic" might be useful for you. I've never used it, since my blood pressure sometimes runs low (sys. 100 mmHg). So if your blood pressure is already normal or low, I wouldn't suggest taking it. Still, you could give it a try, and it's certainly far better than any drug you'd take, given that it's natural.

Appreciate it. Garlic isn't something I've given a shot.

 

[Lifeworthliving]

UgottaBkiddingMe said:

You shed close to 50% of your starting body weight!! That's amazing!!

Same as you, I stayed on tirzep until I reached a "normal" weight. Then I moved to reta for maintenance, drawn by the stories about it protecting muscle and offering perks beyond tirzep. I'm just at week 6.

Remembering that no two bodies are alike and each can respond, or potentially respond, in its own way to anything put into it, this is what I've noticed for myself so far at week 6, after going from 5mg of tirzep every 7 days to 2.5 of reta every 7 days:

- food noise has come back, no question, more than with tirzep, though it's somewhat muted. If that tracks. Before tirzep, it was blaring and unmistakable - 75-level tv volume. On tirzep, it vanished for a year. Perhaps at a clear, yet far lower 25 level tv volume after 1 year. On reta so far, it sits at 40, but muffled, not so crystal clear. A bit easier to tune out than an unmedicated 40.

- could be all in my head or entirely tied to other factors but, I feel a bit more…. Blah? With slightly less energy but a noticeable drop in motivation. I've seen elsewhere that others have gone through this too. Really hoping this fades. So far, not a deal breaker. But, for me, not sustainable long-term.

- again, could be from other factors (I have narcolepsy and I might be nearing or in perimenopause) but, my sleep has been pretty rough. Easily awoken, light sleep, up after 2-3 hours and hard to get back to sleep.

- my skin is super sensitive. Like a body-wide skin ache with some spots feeling a bit sunburned. I wouldn't call it painful, more uncomfortable (2/10 pain if I had to rate it). I've also seen that others go through this too but it fades after a time.

I'm hoping to stay at a low dose (preferably 2.5mg/week or even lower) and might take a 2-3 month break down the road to see if that helps.

Congrats again! And best of luck on your continued journey!

Seeing this helps — I'd been browsing, thinking maybe I was alone in this. That Blah feeling is really odd next to Tirzep.

 

[UgottaBkiddingMe]

Lifeworthliving said:

UgottaBkiddingMe said:

You shed close to 50% of your starting body weight!! That's amazing!!

Same as you, I stayed on tirzep until I reached a "normal" weight. Then I moved to reta for maintenance, drawn by the stories about it protecting muscle and offering perks beyond tirzep. I'm just at week 6.

Remembering that no two bodies are alike and each can respond, or potentially respond, in its own way to anything put into it, this is what I've noticed for myself so far at week 6, after going from 5mg of tirzep every 7 days to 2.5 of reta every 7 days:

- food noise has come back, no question, more than with tirzep, though it's somewhat muted. If that tracks. Before tirzep, it was blaring and unmistakable - 75-level tv volume. On tirzep, it vanished for a year. Perhaps at a clear, yet far lower 25 level tv volume after 1 year. On reta so far, it sits at 40, but muffled, not so crystal clear. A bit easier to tune out than an unmedicated 40.

- could be all in my head or entirely tied to other factors but, I feel a bit more…. Blah? With slightly less energy but a noticeable drop in motivation. I've seen elsewhere that others have gone through this too. Really hoping this fades. So far, not a deal breaker. But, for me, not sustainable long-term.

- again, could be from other factors (I have narcolepsy and I might be nearing or in perimenopause) but, my sleep has been pretty rough. Easily awoken, light sleep, up after 2-3 hours and hard to get back to sleep.

- my skin is super sensitive. Like a body-wide skin ache with some spots feeling a bit sunburned. I wouldn't call it painful, more uncomfortable (2/10 pain if I had to rate it). I've also seen that others go through this too but it fades after a time.

I'm hoping to stay at a low dose (preferably 2.5mg/week or even lower) and might take a 2-3 month break down the road to see if that helps.

Congrats again! And best of luck on your continued journey!

Seeing this helps — I'd been browsing, thinking maybe I was alone in this. That Blah feeling is really odd next to Tirzep.

Exactly?! I'm around week 9 now. I missed 1 week and my most recent dose was 3 days ago. The Blah has returned - during that skipped week it wasn't present. I guess if it reduces the desire for ~not hungry, pleasure food~ then it must do the same for other pleasurable things? If only it could give me the drive to handle everyday, unpleasurable tasks... such as going to work haha