Inflammation Keeps us Alive

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Good-Heart6425

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A New York Times article on chronic inflammation and GLP's: The extensive use of GLP-1s — Ozempic and Zepbound among them — has overturned assumptions about what those answers could be and how quickly we might obtain them. Such drugs seem to lower chronic inflammation across the body to a modest degree, while not hindering the immune system’s capacity to combat infection. For individuals who use GLP-1s for diabetes treatment and to encourage weight loss, some of their chronic conditions have seemed to improve as well.
 
Truly food for thought. I mean, some beneficial reasons for inflammation do exist, yet the way our peptides and GLP-1s wipe it out--does that help us or harm us?
 
QueenMuntha said:

Truly food for thought. I mean, some beneficial reasons for inflammation do exist, yet the way our peptides and GLP-1s wipe it out--does that help us or harm us?
Click to expand...
Having ulcerative colitis, it was a happy surprise to find out that GLP1s might hold inflammation in check.

At my latest blood draw, my C-reactive protein reading came back lower than any I'd previously recorded.

That said, three changes are in play:

1. I began retatrutide

2. I began KLOW

3. My peptide regimen has made me much more consistent with my UC medication.

My sense is that those dealing with auto-immune conditions stand to gain more than the average person.

Absent any evidence that points the other way, my current intention is to stay on reta or tirz for the rest of my life.
 
Troposphere said:

QueenMuntha said:

Truly food for thought. I mean, some beneficial reasons for inflammation do exist, yet the way our peptides and GLP-1s wipe it out--does that help us or harm us?
Click to expand...
Having ulcerative colitis, it was a happy surprise to find out that GLP1s might hold inflammation in check.

At my latest blood draw, my C-reactive protein reading came back lower than any I'd previously recorded.

That said, three changes are in play:

1. I began retatrutide

2. I began KLOW

3. My peptide regimen has made me much more consistent with my UC medication.

My sense is that those dealing with auto-immune conditions stand to gain more than the average person.

Absent any evidence that points the other way, my current intention is to stay on reta or tirz for the rest of my life.
Click to expand...
Same situation here: a daily routine with Reta plus a KPV/BPC combination has eliminated all remaining UC symptoms for me. In fact, I’ve quit taking my regular daily medication.
 
px1984 said:

Troposphere said:

QueenMuntha said:

Truly food for thought. I mean, some beneficial reasons for inflammation do exist, yet the way our peptides and GLP-1s wipe it out--does that help us or harm us?
Click to expand...
Having ulcerative colitis, it was a happy surprise to find out that GLP1s might hold inflammation in check.

At my latest blood draw, my C-reactive protein reading came back lower than any I'd previously recorded.

That said, three changes are in play:

1. I began retatrutide

2. I began KLOW

3. My peptide regimen has made me much more consistent with my UC medication.

My sense is that those dealing with auto-immune conditions stand to gain more than the average person.

Absent any evidence that points the other way, my current intention is to stay on reta or tirz for the rest of my life.
Click to expand...
Same situation here: a daily routine with Reta plus a KPV/BPC combination has eliminated all remaining UC symptoms for me. In fact, I’ve quit taking my regular daily medication.
Click to expand...
That's wonderful news!

I made it 5 years with no medication and no flare ups.

Sadly, the condition returned and I had to restart meds. Still, I believe Mesalamine, KLOW and Reta together work better than Mesalamine on its own.

Hoping everything goes smoothly for you—please update me on how it goes. UC solidarity!
 
I appreciate you posting about what you went through. It’s given me an angle that was new to me.

Although confirmation will require additional clinical evidence, the possible role of GLP-1 in autoimmune conditions and ongoing inflammation is definitely worth watching closely.

I’m grateful you raised a subject that receives too little discussion.
 
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