Inflammation and visceral fat?

[PeptideConsumer]

Through 2018 and into early 2019, I stayed in good—sometimes very good—shape.

Each day I was active, had no body fat percentage, and no health issues whatsoever.

From late 2019 through late 2020, exercise essentially ceased for me. Abdominal muscle definition disappeared (I became fat), and I lost muscle definition overall.

Then, for the first time, I became aware of intolerances to particular chemicals. Melanotan 2 was the initial one to produce side effects in me.

I made small changes to my diet and dropped a bit of weight, yet I did not restart exercising.

Even so, my diet as a whole remained high in sugar and refined carbohydrates.

At the beginning of 2022, tinnitus appeared, together with sinusitis and dermatitis.

After that, my tolerance to additional chemicals dropped, until I had to stop melanotan completely, because by then it was affecting my mood for the first time.

When I was in good shape, I had taken it for years with no side effects at all.

During the past two months, I have begun working to get back into shape. I have always appeared okay, but my midsection is especially just padded.

My assumption is that this is visceral fat—the insidious type, and the one widely known for adding to inflammation.

Visceral fat is deep belly fat that wraps around your internal organs like the liver, pancreas, and intestines. Having too much of it raises your risk for serious health problems like type 2 diabetes and heart disease, even if you look thin on the outside. [1, 2, 3]

Click to expand...

What is Visceral Fat?

• • Hidden fat: It sits deep inside your belly, unlike subcutaneous fat which you can pinch right under your skin.
  • Active tissue: It acts like an active organ in your body, releasing harmful chemicals and hormones that cause inflammation and insulin resistance. [1, 2]

Health Risks

• • Type 2 diabetes: Stops your body from using insulin the right way.
  • Heart disease: Raises your blood pressure and blood cholesterol, which can block your blood vessels.
  • Other issues: Linked to liver disease and certain types of cancer. [1, 2, 3]

Main Causes

• • Bad diet: Eating lots of sugar, refined carbs, and processed foods.
  • No exercise: Sitting too much and not burning enough energy.
  • High stress: Stress makes your body release a hormone called cortisol, which tells your body to store fat in the belly.
  • Poor sleep and alcohol: Not sleeping well or drinking too much alcohol. [1, 2, 3, 4]

Click to expand...

I wonder whether, as I continue improving my physical health by returning to regular exercise, the inflammatory symptoms will lessen.

 

[deluge]

Given that you go by PeptideConsumer, it stands out that your post doesn't include any dosage information.

Do you inject any peptides? Some peptides could account for a number of the symptoms you've described. It might also help to know your age and general health, provided you're comfortable sharing those details.

 

[Grogu]

PeptideConsumer said:

Through 2018 and into early 2019, I stayed in good—sometimes very good—shape.

Each day I was active, had no body fat percentage, and no health issues whatsoever.

From late 2019 through late 2020, exercise essentially ceased for me. Abdominal muscle definition disappeared (I became fat), and I lost muscle definition overall.

Then, for the first time, I became aware of intolerances to particular chemicals. Melanotan 2 was the initial one to produce side effects in me.

I made small changes to my diet and dropped a bit of weight, yet I did not restart exercising.

Even so, my diet as a whole remained high in sugar and refined carbohydrates.

At the beginning of 2022, tinnitus appeared, together with sinusitis and dermatitis.

After that, my tolerance to additional chemicals dropped, until I had to stop melanotan completely, because by then it was affecting my mood for the first time.

When I was in good shape, I had taken it for years with no side effects at all.

During the past two months, I have begun working to get back into shape. I have always appeared okay, but my midsection is especially just padded.

My assumption is that this is visceral fat—the insidious type, and the one widely known for adding to inflammation.

Visceral fat is deep belly fat that wraps around your internal organs like the liver, pancreas, and intestines. Having too much of it raises your risk for serious health problems like type 2 diabetes and heart disease, even if you look thin on the outside. [1, 2, 3]

Click to expand...

What is Visceral Fat?

• • Hidden fat: It sits deep inside your belly, unlike subcutaneous fat which you can pinch right under your skin.
  • Active tissue: It acts like an active organ in your body, releasing harmful chemicals and hormones that cause inflammation and insulin resistance. [1, 2]

Health Risks

• • Type 2 diabetes: Stops your body from using insulin the right way.
  • Heart disease: Raises your blood pressure and blood cholesterol, which can block your blood vessels.
  • Other issues: Linked to liver disease and certain types of cancer. [1, 2, 3]

Main Causes

• • Bad diet: Eating lots of sugar, refined carbs, and processed foods.
  • No exercise: Sitting too much and not burning enough energy.
  • High stress: Stress makes your body release a hormone called cortisol, which tells your body to store fat in the belly.
  • Poor sleep and alcohol: Not sleeping well or drinking too much alcohol. [1, 2, 3, 4]

Click to expand...

I wonder whether, as I continue improving my physical health by returning to regular exercise, the inflammatory symptoms will lessen.

Inflammation is indeed lowered by GLP-1 RAs, and this happens along two pathways that overlap. One component is simply a reduction in visceral fat; that fat is metabolically active and drives pro-inflammatory signaling. Another component does not depend on weight loss: receptors for GLP-1 located on vascular tissue and immune cells mediate a direct effect, and signaling in the central nervous system also contributes by reducing systemic inflammatory tone.


JCI - Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits

 

[eidos]

Have a look into inflammasome (https://en.wikipedia.org/wiki/Inflammasome)

An increase in them correlates with visceral fat around the liver and pancreas.

 

[woundcarping]

PeptideConsumer said:

Through 2018 and into early 2019, I stayed in good—sometimes very good—shape.

Each day I was active, had no body fat percentage, and no health issues whatsoever.

From late 2019 through late 2020, exercise essentially ceased for me. Abdominal muscle definition disappeared (I became fat), and I lost muscle definition overall.

Then, for the first time, I became aware of intolerances to particular chemicals. Melanotan 2 was the initial one to produce side effects in me.

I made small changes to my diet and dropped a bit of weight, yet I did not restart exercising.

Even so, my diet as a whole remained high in sugar and refined carbohydrates.

At the beginning of 2022, tinnitus appeared, together with sinusitis and dermatitis.

After that, my tolerance to additional chemicals dropped, until I had to stop melanotan completely, because by then it was affecting my mood for the first time.

When I was in good shape, I had taken it for years with no side effects at all.

During the past two months, I have begun working to get back into shape. I have always appeared okay, but my midsection is especially just padded.

My assumption is that this is visceral fat—the insidious type, and the one widely known for adding to inflammation.

Visceral fat is deep belly fat that wraps around your internal organs like the liver, pancreas, and intestines. Having too much of it raises your risk for serious health problems like type 2 diabetes and heart disease, even if you look thin on the outside. [1, 2, 3]

Click to expand...

What is Visceral Fat?

• • Hidden fat: It sits deep inside your belly, unlike subcutaneous fat which you can pinch right under your skin.
  • Active tissue: It acts like an active organ in your body, releasing harmful chemicals and hormones that cause inflammation and insulin resistance. [1, 2]

Health Risks

• • Type 2 diabetes: Stops your body from using insulin the right way.
  • Heart disease: Raises your blood pressure and blood cholesterol, which can block your blood vessels.
  • Other issues: Linked to liver disease and certain types of cancer. [1, 2, 3]

Main Causes

• • Bad diet: Eating lots of sugar, refined carbs, and processed foods.
  • No exercise: Sitting too much and not burning enough energy.
  • High stress: Stress makes your body release a hormone called cortisol, which tells your body to store fat in the belly.
  • Poor sleep and alcohol: Not sleeping well or drinking too much alcohol. [1, 2, 3, 4]

Click to expand...

I wonder whether, as I continue improving my physical health by returning to regular exercise, the inflammatory symptoms will lessen.

Subcutaneous fat is the kind you can grab between your fingers; it gives a cushioned appearance. Visceral fat sits deeper, behind the abdominal wall. That location can create a bloated look, yet instead of merely adding padding, it forces the muscles outward.

 

[PeptideConsumer]

deluge said:

Given that you go by PeptideConsumer, it stands out that your post doesn't include any dosage information.

Do you inject any peptides? Some peptides could account for a number of the symptoms you've described. It might also help to know your age and general health, provided you're comfortable sharing those details.

Melanotan.

My cycles have included BPC 157, plus the other recovery 'tide—something 200?

Those are the main compounds. Because I'm fair skinned, melanotan is the main one I've used for the longest stretch.

The intolerance came on in a fairly brief window after I stopped a solid exercise routine and became essentially sedentary.

In other words, from very healthy to a terrible lifestyle.

It first showed up at 34. At 32 and 33, I dosed everything with no issue at all (I ended proper exercise/lifestyle at 33.5).

A severe intolerance came another couple of years on, at 36.

And at 37, what had been mild tinnitus at 36 grew stronger.

 

[PeptideConsumer]

eidos said:

Have a look into inflammasome (https://en.wikipedia.org/wiki/Inflammasome)

An increase in them correlates with visceral fat around the liver and pancreas.

Protective factors (for contrast):

• Diets rich in omega-3 fatty acids, polyphenols, fiber, vitamin D, and plant foods (e.g., Mediterranean-style) inhibit NLRP3 via reduced ROS, enhanced autophagy/mitophagy, and anti-inflammatory metabolites.
  
• Caloric restriction, intermittent fasting, exercise, and weight loss lower NLRP3 activity and improve metabolic health.

Click to expand...

Yep.

It lends support to the claim that poor diet/lifestyle fuels chronic inflammation.

 

[Flash-BCR]

PeptideConsumer said:

deluge said:

Given that you go by PeptideConsumer, it stands out that your post doesn't include any dosage information.

Do you inject any peptides? Some peptides could account for a number of the symptoms you've described. It might also help to know your age and general health, provided you're comfortable sharing those details.

Melanotan.

My cycles have included BPC 157, plus the other recovery 'tide—something 200?

Those are the main compounds. Because I'm fair skinned, melanotan is the main one I've used for the longest stretch.

The intolerance came on in a fairly brief window after I stopped a solid exercise routine and became essentially sedentary.

In other words, from very healthy to a terrible lifestyle.

It first showed up at 34. At 32 and 33, I dosed everything with no issue at all (I ended proper exercise/lifestyle at 33.5).

A severe intolerance came another couple of years on, at 36.

And at 37, what had been mild tinnitus at 36 grew stronger.

TB-500?....

 

[aepower2016]

Have you given pre- or probiotics a try? There's evidence that repairing your gut microbiome can lower inflammation, and it may also ease pain associated with minor injuries. I'll include a recent article that covers a study pitting a prebiotic against physical therapy in terms of strength and arthritis pain caused by inflammation. It's merely one among numerous studies that suggest the gut has a central part in lowering inflammation.

A daily fiber supplement reduced knee arthritis pain and improved strength



In a six-week study, knee osteoarthritis pain dropped with a prebiotic fiber supplement, which likewise enhanced handgrip strength and improved pain sensitivity. Those findings suggest an intriguing link among gut, muscle, and pain, and imply that a daily supplement might be simpler to keep up than digital physiotherapy.

www.sciencedaily.com

 

[BlueOctopus]

Your point about returning to a fitter state likely points in the correct direction.

Something I've come to understand: inflammation doesn't always show up as a sensation you can identify right away. It can appear through small shifts instead — slower recovery, poorer sleep, altered skin, and a different energy level.

For a lot of people, boosting fitness and cutting visceral fat appears to ease many of those underlying problems.

 

[CandyCap]

" something 200?"

How OP can not know what is being injected into them really baffles me.

Is anyone else concerned by this?

 

[woundcarping]

CandyCap said:

" something 200?"

How OP can not know what is being injected into them really baffles me.

Is anyone else concerned by this?

Faintly concerning? Not in the slightest.

 

[kenadams]

For most people, health problems come from metabolic dysfunction—inflammation, visceral fat, and insulin resistance acting as the root causes. After I dealt with them, my natural Test rose from 176 to 500. My skin issues, stomach upset, and other symptoms also resolved.

Before using peptides—anything besides Reta, Tirz, etc.—this is what needs attention first.

Following a keto/carnivore diet strictly fixed most of it for me.

 

[PeptideConsumer]

aepower2016 said:

Have you given pre- or probiotics a try? There's evidence that repairing your gut microbiome can lower inflammation, and it may also ease pain associated with minor injuries. I'll include a recent article that covers a study pitting a prebiotic against physical therapy in terms of strength and arthritis pain caused by inflammation. It's merely one among numerous studies that suggest the gut has a central part in lowering inflammation.



View attachment 146



A daily fiber supplement reduced knee arthritis pain and improved strength



In a six-week study, knee osteoarthritis pain dropped with a prebiotic fiber supplement, which likewise enhanced handgrip strength and improved pain sensitivity. Those findings suggest an intriguing link among gut, muscle, and pain, and imply that a daily supplement might be simpler to keep up than digital physiotherapy.

www.sciencedaily.com

Began only a short time ago.

For the pudding, I mix chia seeds with milk and greek yoghurt.

My digestion has gotten much better.

Pre-biotics — I've been hitting them hard for a while now.

Still, taken together, it's likely not been long enough to bring about a full transformation.

I'm eager to see how things go as long as I stay consistent with them.

 

[PeptideConsumer]

kenadams said:

For most people, health problems come from metabolic dysfunction—inflammation, visceral fat, and insulin resistance acting as the root causes. After I dealt with them, my natural Test rose from 176 to 500. My skin issues, stomach upset, and other symptoms also resolved.

Before using peptides—anything besides Reta, Tirz, etc.—this is what needs attention first.

Following a keto/carnivore diet strictly fixed most of it for me.

Melanotan gave me side effects I couldn't tolerate, and I'm sure that's the cause.

That's why I've been pushing my diet changes hard, watching to see whether my inflammatory problems let up. Once they do—hopefully—I can get back to working on a great tan.