Has anyone stacked low-dose Cagri with Reta for food noise?

@Milotic the replies here make one thing clear: there is no single route that suits everyone, and each person's approach looks a little different. Take these experiences as a starting point, but the real answer comes from trying things out and seeing what fits you. And don't be surprised if, a few months down the line, you need to adjust your approach once more. YOU GOT THIS! 😁
 
SoCalGirl said:

@Milotic the replies here make one thing clear: there is no single route that suits everyone, and each person's approach looks a little different. Take these experiences as a starting point, but the real answer comes from trying things out and seeing what fits you. And don't be surprised if, a few months down the line, you need to adjust your approach once more. YOU GOT THIS! 😁
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That's exactly right — thanks so much x
 
Milotic said:

To be fair, that does sound like the smarter approach. Yesterday I really felt like I couldn't keep going through this week feeling that way — though that's a bit dramatic, since I was still in a deficit, just not as harsh a one 🙈 Today I feel okay again though haha. Maybe it was just one of those days haha
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For me, the tiredness from cagri showed up only during the first couple of doses; after that I've been taking about .25 or .3mg every few days.

On some nights I'll take it just before bed alongside my DSIP, and personally I've noticed my sleep getting better.

This weekend, when I dose my Reta — lately it's been sitting in the 5-6 range — I'll go under 4 and am hoping that's enough to lower the metabolic boost.

So far I'm really pleased: my sleep quality is coming back and my hunger is controlled, though not entirely gone.
 
SoCalGirl said:

I'm getting quite close to my weight-loss goal. On top of that, I haven't had a proper night's sleep in roughly 9 months. And when I stand up I get so dizzy that I feel physically ill. Depending on how my progress goes, my plan is 1mg Reta, 1mg Cagri and 1mg Tirz, possibly raising the Tirz if I need to, spread across the week. Tirz does a lot for the food noise, and Cagri combined with Reta absolutely crushes it. It's so individual — everyone has to keep trying and experimenting until they find the sweet spot. And then it changes! 🤣

Some of us (I can't speak for everyone) want to try EVERY. DAMN. THING. in large amounts! 🤣
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In this one way, I suppose I'm fortunate that my budget isn't unlimited...

I'm holding out for Elora's price to drop, though that could leave me feeling I NEED to pick up some cagri....
 
peterpayne said:

In this one way, I suppose I'm fortunate that my budget isn't unlimited...

I'm holding out for Elora's price to drop, though that could leave me feeling I NEED to pick up some cagri....
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honestly that's basically my whole strategy too lol. there's always one more thing to try
 
peterpayne said:

In this one way, I suppose I'm fortunate that my budget isn't unlimited...

I'm holding out for Elora's price to drop, though that could leave me feeling I NEED to pick up some cagri....
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I'm in the same boat! Elora is the one I'd go for if/when the price comes down. If food noise creeps in while I'm waiting, Cagri is what I'd fall back on.
 
Milotic said:


Currently on 3mg Reta. My current dosing schedule has looked like this:

0.5mg x 1 week

1mg x 3 weeks

1.5mg x 3 weeks

2mg x 3 weeks

3mg x 2 weeks

Overall, it's working well, but sometimes I'm still struggling with food noise and cravings, particularly for sweet things.

Some days my appetite suppression is great, but other days I'm noticeably hungrier. I'll eat a meal and feel satisfied, yet an hour later I'm already thinking about having a snack. Today has been difficult which surprised me considering it's the second week on 3mg but I have found the noise louder than usual this whole week, if I'm honest. Nothing like it was before GLP but still present and annoying - I'd rather not be tempted at all.

I'm considering adding low-dose Cagri rather than continuing to increase Reta, as I don't want to get the bad side effects by increasing too quickly. I have got one vial of Cagri to try as I have been interested in a while but I keep going back and for on whether to actually commit to a small dose of 0.25.

Has anyone added Cagri while on a relatively low dose of Reta? What made you decide to add it rather than increase Reta, and did it help with food noise?

I'm also curious whether staying on a lower Reta dose means missing out on any of its metabolic benefits - although I do feel I shouldn't be that worried about this as I track my calories and have my nutrition dialled down tbh and I have lost 9kg since August 3rd.

Would love to hear your experiences, good or bad!

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Raise your Reta dose!

My honest opinion: don't even consider Cagri until you've worked up to 6-8mg of Reta, split every 3 days!

Beyond that, dividing your dose so you pin every 3 days made a huge difference for me

And keep cagri as your final resort — it wiped out my appetite entirely and left me feeling like a zombie!
 
NotNba said:

Raise your Reta dose!

My honest opinion: don't even consider Cagri until you've worked up to 6-8mg of Reta, split every 3 days!

Beyond that, dividing your dose so you pin every 3 days made a huge difference for me

And keep cagri as your final resort — it wiped out my appetite entirely and left me feeling like a zombie!
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Appreciate it! Rather than adding anything, I'll concentrate on moving my Reta dose up and see how that treats me. I've been cautious so far, but it seems like the moment has come to push it higher 😎 while obviously not rushing it…
 
TriDiddy said:

Before you add another compound, I'd raise your Reta dose to at least 4mg. Research indicates the glucagon component only becomes fully active from 4mg onward, so below that point you haven't gotten the full benefit of all 3 receptors that Reta engages.

For what it's worth, I went up very gradually and I'm now in my 12th week at 4mg, with a planned step to 6mg next week. At 4mg the results were very effective for me.
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I keep my weekly adjustments to 0.5mg, or 1mg at most. One perk of gray market peptides is that we can pick any dose we like, so there's no need to follow the big step-ups that come with pharma's pre-filled pens. That said, the side effects I've had are what keep me very cautious.
 
NotNba said:

Raise your Reta dose!

My honest opinion: don't even consider Cagri until you've worked up to 6-8mg of Reta, split every 3 days!

Beyond that, dividing your dose so you pin every 3 days made a huge difference for me

And keep cagri as your final resort — it wiped out my appetite entirely and left me feeling like a zombie!
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I don't agree with that take.

In medicine it's common for doctors to combine 2 drugs at moderate doses instead of pushing a single drug to its max.

If someone wants faster weight loss, getting past the 4mg hump so the glucagon from Reta kicks in is a key step.

That said, hunger suppression was never Reta's strong suit. That's why adding a second drug makes sense — one better suited to that job.

One more upside I've noticed: cagri can ease the sleep problems Reta brings, which tend to get worse as the dose climbs.
 
Clavicular's Hammer said:

I don't agree with that take.

In medicine it's common for doctors to combine 2 drugs at moderate doses instead of pushing a single drug to its max.

If someone wants faster weight loss, getting past the 4mg hump so the glucagon from Reta kicks in is a key step.

That said, hunger suppression was never Reta's strong suit. That's why adding a second drug makes sense — one better suited to that job.

One more upside I've noticed: cagri can ease the sleep problems Reta brings, which tend to get worse as the dose climbs.
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I'm not looking to pick a fight here,

6mg is 1/2 of reta's "max" dose, and plenty of people pin far more than that.

Sure, hunger suppression isn't reta's strongest area, but IMO there's still enough GLP receptor headroom to get suppression, particularly at 3mg weekly given the 6-day half life.

Just dialing that in (every 6 days, or E3.5D) and then titrating up is far more subtle than bringing in a newer compound (cagri), which hits a lot of people pretty hard and targets a different receptor.

The usual approach I see is to "milk" reta for all it's worth, then add cagri once you feel your reta dose has climbed too high without meaningful suppression or with more sides showing up.

Suggesting a new pep before the titration phase is even done isn't the way IMO
 
Climbing in small steps like that really does matter. A lot of the side effects people mention tend to show up when the next bump comes before the previous one has had a chance to build up.

bokonon said:

I keep my weekly adjustments to 0.5mg, or 1mg at most. One perk of gray market peptides is that we can pick any dose we like, so there's no need to follow the big step-ups that come with pharma's pre-filled pens. That said, the side effects I've had are what keep me very cautious.
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I realize this goes beyond what the OP asked, but the OP and everyone reading should also think about sema as a way to break through a plateau...I have both cagril and sema on hand, and on my reta dose I was noticing a bit more hunger than I get from my tirz dose...I'm running the minimum sema dose between my reta and tirz pins, and I'm loving how it bridges the hunger gap between pins flawlessly...

At lower doses I don't really experience symptoms, and it wipes out the food noise....I might give cagril a try at some point, but I'm wary of the fatigue and GI issues some people report with it...glad I went with the sema..."a ladyJ recommendation™" 👍
 
What strategy makes sense at this stage really comes down to your context. Are you aiming to drop 10 kilos or 60? Age, height, starting, current and goal weights would help.

The most straightforward path is to keep raising the reta dose until it does the job well — meaning hunger or food noise is kept reasonably in check at a calorie intake that produces weight loss at a sensible pace, with no major side effects. Forums are full of claims that reta isn't strong for appetite suppression or food noise, but in reality it's the most effective weight-loss drug, and almost all of that comes from eating less, plus perhaps a bonus 1-200 kcal/day of metabolic boost via glucagon agonism. That effect is dose dependent, smaller at lower doses, and the notion that some threshold dose like 4mg is where it kicks in simply isn't sound science.

The one genuine downside of adding low-dose cagri now, while you're still titrating reta, is figuring out which drug is responsible for what — whether useful effects or side effects. In theory, a lower reta dose plus some cagri might deliver similar weight loss to a higher reta dose with fewer side effects, but that hasn't been studied yet, and cagri overall has fairly high rates of side effects. Generally I'd suggest the simpler route first: raise the reta dose if side effects aren't an issue. If you have a lot of weight to lose, then adding cagri (or elora) to a high reta dose makes sense. And start cagri low, like 0.25mg/w, especially when adding it to tirz or reta.
 
TriDiddy said:

Before you add another compound, I'd raise your Reta dose to at least 4mg. Research indicates the glucagon component only becomes fully active from 4mg onward, so below that point you haven't gotten the full benefit of all 3 receptors that Reta engages.

For what it's worth, I went up very gradually and I'm now in my 12th week at 4mg, with a planned step to 6mg next week. At 4mg the results were very effective for me.
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I doubt I've ever gotten the glucagon component going, but stacking it with tirz feels different from tirz by itself. I can't put my finger on why, but I'll take the result : )
 
The claim that Reta doesn't touch the glucagon receptor until you hit 4mg has zero scientific basis. Sure, higher doses ramp up that activity more, but even at 1mg it's still acting on the receptor — and that may help explain why it performs so well at low doses. Take 1mg/w over 80 weeks: that produced 9% weight loss, which is way more than any other GLP achieves at such a low dose.
 
NotNba said:

I'm not looking to pick a fight here,

6mg is 1/2 of reta's "max" dose, and plenty of people pin far more than that.

Sure, hunger suppression isn't reta's strongest area, but IMO there's still enough GLP receptor headroom to get suppression, particularly at 3mg weekly given the 6-day half life.

Just dialing that in (every 6 days, or E3.5D) and then titrating up is far more subtle than bringing in a newer compound (cagri), which hits a lot of people pretty hard and targets a different receptor.

The usual approach I see is to "milk" reta for all it's worth, then add cagri once you feel your reta dose has climbed too high without meaningful suppression or with more sides showing up.

Suggesting a new pep before the titration phase is even done isn't the way IMO
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Not looking to argue either — we're all here to learn

I haven't gone through the studies myself, but even though 12mg was the maximum that got studied, a large share of participants dropped out at those high doses. That suggests the highest practical dose for most people lands around 8mg, where many report severe side effects, or where some probably begin building a massive tolerance.

Instead of pushing ourselves to failure, I'd suggest going only slightly above the dose that activated glucagon — 4-6mg.

Then stack a second, also moderate, dose of a compound that's better suited to hunger suppression.

Just my two cents, and a protocol that comes closer to what's practiced in real medicine.
 
lessthanhalf said:

The claim that Reta doesn't touch the glucagon receptor until you hit 4mg has zero scientific basis. Sure, higher doses ramp up that activity more, but even at 1mg it's still acting on the receptor — and that may help explain why it performs so well at low doses. Take 1mg/w over 80 weeks: that produced 9% weight loss, which is way more than any other GLP achieves at such a low dose.
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For those who take very small doses, heart rate usually barely budges. Once they get near the 4mg mark, though, the majority notice that 10pm uptick. My guess — and it's only a guess, I have no hard evidence — is that glycogen activation is behind it.
 
Yup! I take 0.5mg of Cagri, divided into 2 doses on Monday and Thursday, and stack it with 4mg of Reta. It works like a charm.
 
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