CranberryRocker
Explorer
You've raised some great points. Storage, reconstitution, and similar factors are things we handle on our side of the process, so that's the extent of what we can manage. That said, my personal take is this: because going grey saves me so much money, I'm able to nudge my dose upward a little to make up for any difference, and it also lets me fine-tune things precisely. I don't stick to the 2.5mg step-ups — instead I go up by just 1mg each time, divided across my 2 weekly shots, which keeps side effects to a minimum. If the molecule that's actually available is slightly less potent, a modest dose bump can offset that, but the way those bioavailable molecules act is still exactly the same as the original, since the receptor is so highly specific. Splitting the dose means I can run 'smaller' trial doses to gauge the response. For most people on higher doses, any difference probably goes unnoticed — over time the obvious side effects tend to fade and shift from week to week anyway, thanks to the body adjusting, hormones, and so on — yet the biological effect doesn't change. Even Eli Lilly sets a BUD, which shows they anticipate activity dropping off over time. On top of that, it comes down to whatever level QA and the different regulatory bodies are willing to accept.