Experiment failed

[Bioexplorer]

So the degree to which sema, tirz, and reta appear to lower inflammation seems tied to getting the GLP-1 and GIP agonist mix just right. Yet it gets confusing: tirz does a better job at reducing inflammation than sema, which has no GIP effect, while reta is a stronger GIP agonist than tirz but apparently does not reduce perceived inflammation as well.

Could reta's glucagon agonist action be blunting some of the upside from its GIP and GLP-1 parts? Or does tirz have some non-incretin mimetic effect that we don't yet know about?

 

[endlrls]

cloratheshadow said:

Before this, my stack was about 9mg Tirz plus 4mg Reta, and fat loss was going well…then I got the idea to swap Tirz out for Sema, since Sema costs less and Reta already covers GIP. That was a huge mistake.

Instead of improving, I ended up feeling way more inflamed and bloated, and the scale wouldn’t move. On top of that, the food noise came rushing back, and any mental restraint I had is completely gone. So now I’ve gone back to 5mg Tirz and the change is already noticeable! I still need my levels to build back up, but I’m stunned by how big the difference is.

Tirz, I’m sorry I ever doubted you

Tirzepatide in the background, just judging siliently

 

[endlrls]

cloratheshadow said:

Before this, my stack was about 9mg Tirz plus 4mg Reta, and fat loss was going well…then I got the idea to swap Tirz out for Sema, since Sema costs less and Reta already covers GIP. That was a huge mistake.

Instead of improving, I ended up feeling way more inflamed and bloated, and the scale wouldn’t move. On top of that, the food noise came rushing back, and any mental restraint I had is completely gone. So now I’ve gone back to 5mg Tirz and the change is already noticeable! I still need my levels to build back up, but I’m stunned by how big the difference is.

Tirz, I’m sorry I ever doubted you

My sister is on the verge of dropping Reta—according to her, injection day feels like getting slammed by a freight train, and what stood out most was the rise in body temperature. On top of that, there isn't much of a difference in weight loss (3 mg RETA, 5 Tirzepatide). I keep probing her about the RHR increase, but she hasn't picked up on that. Seems like the remainder of the kit I purchased stays with me!

 

[GLP1Pharmacist]

Alternating Reta and Sema, seeing great outcomes; fascinating how much variation there is from person to person.