Experiment failed

[Bioexplorer]

So it seems like the impact on perceived inflammation reduction of sema, tirz, and reta depends on the right balance of GLP-1 and GIP agonist effects. But it gets puzzling when you consider that tirz is better at reducing inflammation than sema with no GIP effect and reta is a stronger GIP agonist than tirz but apparently not as effective at perceived inflammation reduction.

Does the glucagon agonist effect of reta counter some of the benefits of the GIP and GLP-1 components of the peptide? Or is there some unknown non incretin mimetic effect of tirz?

 

[endlrls]

cloratheshadow said:


So I was previously taking around 9mg Tirz 4mg Reta and I was losing fine…but I thought I’d try replacing Tirz with Sema because Sema is cheaper and Reta also has GIP. Boy was I WRONG.

Not only do I feel more inflamed and bloated than I was, but my weight stalled. And the food noise is back. I don’t have the mental restraint anymore at all. So I’m now back taking 5mg Tirz and I already feel a difference! Need to get the levels back up in my system but I’m shocked the difference.

I’m sorry I doubted you, Tirz

Click to expand...

Tirzepatide in the background, just judging siliently

 

[endlrls]

cloratheshadow said:


So I was previously taking around 9mg Tirz 4mg Reta and I was losing fine…but I thought I’d try replacing Tirz with Sema because Sema is cheaper and Reta also has GIP. Boy was I WRONG.

Not only do I feel more inflamed and bloated than I was, but my weight stalled. And the food noise is back. I don’t have the mental restraint anymore at all. So I’m now back taking 5mg Tirz and I already feel a difference! Need to get the levels back up in my system but I’m shocked the difference.

I’m sorry I doubted you, Tirz

Click to expand...

My sister is actually about the pull out Reta, she said dose day it hits her like a freight train and she noticed the body temp increase more than anything else. Not really much of a weight loss difference as well (3 mg RETA, 5 Tirzepatide). I keep asking her about the RHR increase but she hasn't noticed that. Looks like I get to keep the rest of the kit I bought!

 

[GLP1Pharmacist]

Rocking Reta/Sema with excellent results, interesting in the variability between people.