Does Tirzepatide Protect the Brain? Reading the GIP/GLP1-RA Evidence

RetCurious

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"Background: tirzepatide (TZP) is the first approved dual agonist acting on both glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and it has shown neuroprotective activity in preclinical models and in early observational studies. This review maps and appraises the pre-clinical and clinical evidence assembled so far for its possible neuroprotective role in idiopathic intracranial hypertension, brain tumour response, neurovestibular disorders, cerebrovascular outcomes, neuroinflammation, and neurodegenerative disease (Parkinson's and Alzheimer's)."


https://pubmed.ncbi.nlm.nih.gov/42608956/
 
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