Do GLP1 peptides interact with meds?

Grogu said:

Absolutely, 100%. Beyond oral contraceptives losing effectiveness while on glp1s, weight loss itself can boost fertility — and together those two factors create a real risk of pregnancies that are unplanned or badly timed. That's not an ideal scenario. I also question whether delayed gastric emptying might affect how other medications get absorbed. Honestly, I think the answer is simply unknown at this point…
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Plus, they become more attractive and easygoing thanks to the confidence they've gained! I really wish Lilly would broadcast this loudly in their ads.
 
bamagirl26 said:

Plus, they become more attractive and easygoing thanks to the confidence they've gained! I really wish Lilly would broadcast this loudly in their ads.
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With Zep... before long you'll be looking so good that you end up a brand-new parent!

Well, that would be a novel approach. 😉
 
BNLFL said:

I take Metoprolol and Lisinopril, and I haven't had any problems.
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After dropping the weight, did you take another look at your high blood pressure?

I also take Lisinopril, and I'm asking myself whether I still need it.
 
Skidude said:

After dropping the weight, did you take another look at your high blood pressure?

I also take Lisinopril, and I'm asking myself whether I still need it.
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Most likely not:

https://www.drmcdougall.com/educati...-treat-patients-with-elevated-blood-pressure/

A sustained elevation of blood pressure to 160/100 mmHg or greater over months suggests the need for treatment with medication. A word of caution: If you do start blood pressure-lowering medications, avoid overly aggressive treatment. In general, reducing blood pressure below 140/90 mmHg with medication is not beneficial and actually will increase the risk of heart attacks, strokes, and death. A recent review by the well-respected Cochrane Collaboration concluded with: “Treating patients to lower than standard BP targets, ≤140-160/90-100 mmHg, does not reduce mortality or morbidity.”

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That material points to the Cochrane review from 2009, yet even with additional studies appearing a decade afterward, the conclusion held that it still isn't worthwhile:

Blood pressure targets in adults with hypertension - Cochrane 2020

The only significant benefits in the group assigned to 'lower' blood pressure targets was a small reduction in the incidence of heart attack and a small reduction in the incidence of congestive heart failure. However, the lower target group had an increase in the number of other serious adverse events. High‐certainty evidence showed there was no difference in death from any cause or total serious adverse events with lower as compared to standard blood pressure targets.

For the general population of persons with elevated blood pressure the small benefits of trying to achieve a lower blood pressure target rather than a standard target (≤ 140/90 mm Hg) do not outweigh the harms. Further research is needed to see if some groups of patients would benefit or be harmed by lower targets.

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Calm Logic said:

Most likely not:

https://www.drmcdougall.com/educati...-treat-patients-with-elevated-blood-pressure/



That material points to the Cochrane review from 2009, yet even with additional studies appearing a decade afterward, the conclusion held that it still isn't worthwhile:

Blood pressure targets in adults with hypertension - Cochrane 2020
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I plan to book an appointment with Doc to find out, but my dose has been cut back a lot for more than a year, and the last reading I had was averaging 120/80.

Good article, thanks
 
Skidude said:

After dropping the weight, did you take another look at your high blood pressure?

I also take Lisinopril, and I'm asking myself whether I still need it.
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My blood pressure has dropped a bit. My cardiologist is unaware that I'm taking Reta. He's a bit of a goodie two shoes. According to him, 2 beers is too much. I suspect I could stop both, but they don't bother me.
 
Skidude said:

I plan to book an appointment with Doc to find out, but my dose has been cut back a lot for more than a year, and the last reading I had was averaging 120/80.

Good article, thanks
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My blood pressure is generally around 120-130/75-70. My heart rate has also returned to normal now.
 
BNLFL said:

My blood pressure has dropped a bit. My cardiologist is unaware that I'm taking Reta. He's a bit of a goodie two shoes. According to him, 2 beers is too much. I suspect I could stop both, but they don't bother me.
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I'm hoping to get off Hydrochlorothiazide.

I'll be seeing the doctor next week.

Diuretics aren't ideal alongside GLP1s, and they're even worse with TRT.. so I'm hoping I can stop it.

BNLFL said:

My blood pressure is generally around 120-130/75-70. My heart rate has also returned to normal now.
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That's great!

Apart from Reta, he'll be aware of the weight loss, and that alone may be enough to come off BP meds.
 
Skidude said:

I'm hoping to get off Hydrochlorothiazide.

I'll be seeing the doctor next week.

Diuretics aren't ideal alongside GLP1s, and they're even worse with TRT.. so I'm hoping I can stop it.


That's great!

Apart from Reta, he'll be aware of the weight loss, and that alone may be enough to come off BP meds.
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He knows about the weight loss, buddy. I get weighed at every appointment and he brings it up.
 
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