lastresort
Explorer
Has anyone here run into downsides after lowering their retatrutide dose?
Right now I'm on RT at 15mg plus 700mg/week of T propionate, and although it got me past the 240lb plateau, I keep wondering whether such a big RT dose is blunting muscle synthesis. Between the anecdotes I have read and how RT is supposed to work, it comes down to three points:
1. Ongoing GCG receptor activation drags mTOR activation down, which cuts into muscle synthesis and makes the whole picture effectively catabolic.
2. That said, retatrutide favours lipid oxidation over amino acid oxidation, so it wastes less muscle than you might fear.
3. Anabolics block the pathways that break muscle down while raising nitrogen retention and synthesis.
So the real question is whether 15mg of retatrutide still earns its keep. I began at 2mg in March and climbed steadily through 4mg, 6mg, 8mg, 12mg and 14mg. Fair warning: I have had neither the time (nor, thanks to a few surprise expenses, the money) for a DEXA scan, yet raising the reta dose never noticeably sped my fat loss up.
On the other side of it, some people reported that stacking reta onto anabolics made cutting far easier, at the price of visibly slower muscle growth.
Would it be sensible to try pulling the retatrutide dose back and just watching what happens?
EDIT: typical daily intake lands around 200-240g protein, 170-200g carbohydrate and under 40g fat.
Right now I'm on RT at 15mg plus 700mg/week of T propionate, and although it got me past the 240lb plateau, I keep wondering whether such a big RT dose is blunting muscle synthesis. Between the anecdotes I have read and how RT is supposed to work, it comes down to three points:
1. Ongoing GCG receptor activation drags mTOR activation down, which cuts into muscle synthesis and makes the whole picture effectively catabolic.
2. That said, retatrutide favours lipid oxidation over amino acid oxidation, so it wastes less muscle than you might fear.
3. Anabolics block the pathways that break muscle down while raising nitrogen retention and synthesis.
So the real question is whether 15mg of retatrutide still earns its keep. I began at 2mg in March and climbed steadily through 4mg, 6mg, 8mg, 12mg and 14mg. Fair warning: I have had neither the time (nor, thanks to a few surprise expenses, the money) for a DEXA scan, yet raising the reta dose never noticeably sped my fat loss up.
On the other side of it, some people reported that stacking reta onto anabolics made cutting far easier, at the price of visibly slower muscle growth.
Would it be sensible to try pulling the retatrutide dose back and just watching what happens?
EDIT: typical daily intake lands around 200-240g protein, 170-200g carbohydrate and under 40g fat.
