BBA1969 said:
kazza94x said:
BBA1969 said:
kazza94x said:
BBA1969 said:
Wh
kazza94x said:
Has anyone given this combination a go? AI reckons it's too much, but for me the reta seems to quit doing its job, so to speak, as the week progresses.
What does your weekly Retatrutide dose look like?
Reta, 4mg a week.
That dose isn't high at all — it's the minimum therapeutic amount once you're past titration. For a late-week dip in appetite suppression, I'd lean toward bumping it up a step rather than bringing in a 2nd or 3rd compound.
If the only issue is food noise creeping back on day 5-6, two options: split your Reta dosing, or inject every 6 days.
On combining: Reta + Cagri is a reasonable pairing. Adding Sema would push things too far, and that's where the worst side effects become most likely.
What I run each week for weight loss => 2x4mg Reta (Mo&Fr) + 2x3mg Tirz (We&Su)
Thanks for breaking that down — isn't sema basically the same thing as tirz? Your combo sounds intriguing. Does it actually deliver for you? Reta is supposed to be the "holy grail". So should I bump it to 5mg reta? Truthfully I don't want to be completely without hunger, yet I also don't want to end up bingeing lol
Semaglutide goes by the brand names Ozempic and Wegovy, while Tirzepatide is sold as Mounjaro and Zepbound.
In terms of receptor action, Sema hits 1 target, Tirz hits 2, and Reta hits 3.
Even though Reta works on 3 receptors, nothing has beaten Tirz for me personally when it comes to killing appetite. So instead of maxing out 1 drug, I combine them at a moderate dose.
Splitting the dose matters too. Back when Mounjaro was the only thing I used, I switched to splitting it so hunger stayed steady all week. With 1 shot, days 6 and 7 were a struggle to keep eating under control; injecting half every 3.5 days smoothed it out — no highs, no lows. It also helps a lot with limiting unpleasant side effects when the dose goes up.
