Back on Tirz After a Break — Not Feeling It

Carrying excess weight carries far greater health dangers than any GLP1 does. The decision is simple.

I wouldn't spend time parked at a 5mg or 7,5mg dose when it isn't giving you the result you're after.

When side effects aren't an issue, simply raise the dose — your body will get such relief that the weight comes off.
 
Aliakaraza said:

How did you build that graph? I'd like to plot one for myself too...
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You can find plenty of breadcrumbs out there to satisfy that curiosity. It wouldn't be very fair if I just said glp1plotter ... oh DOH! /lol 😉

Try making a few different graphs and see how the blood level shifts.
 
Skidude said:

the final 20lbs were really difficult for me.

What I was really curious about is how that signaling would impact people who made no effort to preserve muscle while they were losing, and whose progress then got sharply halted or materially slowed because the "biological signal" shut down their weight loss — like in the study that was posted and the bolded part of my earlier post.
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That's a fascinating angle, actually. My original thought was just about a typical person who missed a handful of doses. But muscle tissue does play a big role in glucose regulation — it's where sugar gets stored as glycogen.

So there are several directions we could take this. I ran a version through AI with this prompt: "Can we theorize how two patients, one with average muscle and one with muscle loss would handle being on a high dose glp-1 for one year then both suddenly stop? Trying to figure out the biology of what happens to both of them."

What came out: the individual with muscle loss fares considerably worse than if they'd never touched a GLP-1 at all, ending up above their prior heaviest weight. The one with average muscle begins a gradual regain — potentially under 10 pounds per year if they stay active, or substantially more if they stop exercising. Neither was assumed to follow any diet.

So your instinct that muscle mass is a major factor in the aftermath looks like it holds up.

One of the follow-up prompts it generated: "Should we map out the specific hormonal changes (like leptin and ghrelin) that drive the sudden cravings after stopping?"
 
HouseCat said:

When I first began compounded, my thinking was heavily focused on saving money. Keeping the dose as low as I could appealed to me both for the cost and because it left room to move upward later. Whether I could afford larger doses worried me a lot. In hindsight I hurt my own progress by increasing slower than I really should have!

Now that GLPs are comfortably within my budget, I'm sticking to the widely shared tirz titration infographic. My current regimen is tirz 7.5mg plus Elora 3mg, and if my loss over the past 4 weeks drops under 2%, I'll raise both medications by 1mg.

Around this forum, I see the full spectrum — super responders on low doses, people titrating high, and a few who titrate extremely high! Another reason I don't feel pressure to stay as low as possible: most study participants appear to shed the majority of their weight within the first 72-90 weeks, so I want to lose as much as I can during that first year and a half while I'm able to. (My goal is 111lbs, so it will take a while - but I'm 50lbs down so far!)





View attachment 14102
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I saved that diagram — it made me realize I should start tracking everything properly so I can get a clearer picture!!
 
On the bright side, I have Type 2 diabetes, but my latest blood work came back showing my HbA1c dropped from 89 two years ago to 34 now — which puts me in Remission. I dropped a lot of weight through strict dieting during that first year, but after that I hit a wall, and Tirz/Mounjaro has genuinely changed my life!
 
Pace5000 said:

My honest advice: pay attention to what your body is telling you.

As long as you aren't having side effects, simply titrate upward until you reach whatever dose you need.

For my 3rd shot I went with 10mg, and I experienced no side effects.

Then last Thursday I took 7.5mg, and that didn't suppress my hunger sufficiently. So I followed up on Sunday with 11.25mg.

Since that point I've felt satisfied and it's been perfect — no side effects.

If you have no side effects, there's nothing to be afraid of. Anything up to 15mg is super safe.
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Calling that "guidance" irresponsible barely covers it — it's flat-out absurd. This isn't the Wild Fucking West, John Wayne.

Within a single sentence you told someone to take 18.75mg across 3 days. Then, just two sentences later, you flip and say "anything up to 15mg is super safe." Do you have even a faint idea what you're doing? Do you understand how these products actually work?

A glp-1 agonist needs 4-5 weeks to accumulate in the body and hit steady state. These medications are long-acting and were DESIGNED for weekly dosing. Therapeutic efficacy depends on reaching steady state.

Titration schedules aren't arbitrary. Our approach is to push people toward educating themselves, staying mindful, and choosing caution over recklessness.

Take your bro medicine somewhere else. JFC.
 
HereKittyKitty said:

Calling that "guidance" irresponsible barely covers it — it's flat-out absurd. This isn't the Wild Fucking West, John Wayne.

Within a single sentence you told someone to take 18.75mg across 3 days. Then, just two sentences later, you flip and say "anything up to 15mg is super safe." Do you have even a faint idea what you're doing? Do you understand how these products actually work?

A glp-1 agonist needs 4-5 weeks to accumulate in the body and hit steady state. These medications are long-acting and were DESIGNED for weekly dosing. Therapeutic efficacy depends on reaching steady state.

Titration schedules aren't arbitrary. Our approach is to push people toward educating themselves, staying mindful, and choosing caution over recklessness.

Take your bro medicine somewhere else. JFC.
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With any drug that has a half-life, the goal is to hold the level steady rather than let it swing.

A 5-day half-life drug being dosed once a week is purely about convenience for the person using it. The thinking is that a weekly schedule is easier to remember, so a routine forms around it.

Believe it or not, the ideal setup would actually be a daily injection.

The huge gap between the day you inject and day 6 gives the user nothing.

Now the dose. What goes wrong at a higher dose? Which organs or processes does it hit negatively? Honestly, the realistic things to watch are the known side effects, such as nausea or sulphur burps. If none of those show up, I don't see a problem.

Consider what happened with semaglutide and how the max dose tripled in a short span — that says a lot.

Think about why those max doses exist. They're there to keep people from damaging their health or causing strong side effects that bring no extra benefit. Whatever the makers set has to be safe for millions upon millions of people; they're protecting themselves.
 
AngieHolmes said:

Honestly, it baffles me that people turn this into some kind of competition — yet you're right that some do. I genuinely don't get it. On this forum I don't really notice it, but over on reddit, for instance, it functions like a strange test of worth. Just use whatever amount gives you the results you want!

It's comparable to asking somebody how much shampoo they go through . . . and then deciding they're superior because you use a quarter-size amount while they "only" use a dime. I mean, if that's what it takes for you to feel good about yourself, I suppose?

And then at the opposite extreme, you've got people who won't accept that a small dose could possibly work. They read bad motives into anyone who says they use one. They must be lying — it has to be a sales pitch! That's wild to me.

At this point I've more or less concluded that someone else's dose tells you almost nothing, and I wonder why we even bother discussing it. Heavier people reach goal on "microdoses," while people with less to lose will push past the boundaries of 15mg.

Does anyone else spot correlations I'm missing? Any studies showing I'm full of it? It's mystifying.
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I'm in full agreement. I've helped roughly 20 patients lose weight, and the dose each person requires varies a great deal. Research tends to favor similar doses, largely so that any results can be credited to the dose itself, but when it comes to real-world practice, it's fair to say the effective dose differs widely from one person to the next.
 
Splitting your dose can help you return to an effective level sooner while avoiding harsh peaks. You can split it into 2x per week or even more frequently. Since a glp1-plotter was brought up earlier, it's worth using it to see what splitting would produce and how much sooner you'd get to the point where the peaks of a steady dose reach roughly the same height.

If you had dropped from 5 to 2.5 or 3.5 with no pause in between, you might feel just as little as you do now, once the dose settles at a constant peak level.
 
Pace5000 said:

My honest advice: pay attention to what your body is telling you.

As long as you aren't having side effects, simply titrate upward until you reach whatever dose you need.

For my 3rd shot I went with 10mg, and I experienced no side effects.

Then last Thursday I took 7.5mg, and that didn't suppress my hunger sufficiently. So I followed up on Sunday with 11.25mg.

Since that point I've felt satisfied and it's been perfect — no side effects.

If you have no side effects, there's nothing to be afraid of. Anything up to 15mg is super safe.
Click to expand...

Pace5000 said:

Carrying excess weight carries far greater health dangers than any GLP1 does. The decision is simple.

I wouldn't spend time parked at a 5mg or 7,5mg dose when it isn't giving you the result you're after.

When side effects aren't an issue, simply raise the dose — your body will get such relief that the weight comes off.
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What makes this 'advice' so risky is that you won't discover the potentially debilitating side effects until you're already in way, way over your head. Recommending this is a terrible idea.
 
Pace5000 said:

My honest advice: pay attention to what your body is telling you.

As long as you aren't having side effects, simply titrate upward until you reach whatever dose you need.

For my 3rd shot I went with 10mg, and I experienced no side effects.

Then last Thursday I took 7.5mg, and that didn't suppress my hunger sufficiently. So I followed up on Sunday with 11.25mg.

Since that point I've felt satisfied and it's been perfect — no side effects.

If you have no side effects, there's nothing to be afraid of. Anything up to 15mg is super safe.
Click to expand...
That titration schedule makes no sense to me. You went from 10mg to 7.5mg after some amount of time you didn't specify? And then, just 3 days after the 7.5mg, you took 11.25mg?

What exactly are you trying to do here?
 
Pace5000 said:

With any drug that has a half-life, the goal is to hold the level steady rather than let it swing.

A 5-day half-life drug being dosed once a week is purely about convenience for the person using it. The thinking is that a weekly schedule is easier to remember, so a routine forms around it.

Believe it or not, the ideal setup would actually be a daily injection.

The huge gap between the day you inject and day 6 gives the user nothing.

Now the dose. What goes wrong at a higher dose? Which organs or processes does it hit negatively? Honestly, the realistic things to watch are the known side effects, such as nausea or sulphur burps. If none of those show up, I don't see a problem.

Consider what happened with semaglutide and how the max dose tripled in a short span — that says a lot.

Think about why those max doses exist. They're there to keep people from damaging their health or causing strong side effects that bring no extra benefit. Whatever the makers set has to be safe for millions upon millions of people; they're protecting themselves.
Click to expand...
I agree with you that the weekly injection probably exists more to keep patients compliant, given the 5-day half-life. I've also read that holding each dose for four weeks is mainly about controlling side effects and letting the body adjust to the drug. In the Eloralintide studies (an amylin receptor agonist, so not a GLP-1), some participants began at 9g, which is the max dose. In SURMOUNT, everyone on tirzepatide starts at 2.5mg and then titrates upward.

Of course, how you medicate your own body is your call. It's also possible I'm misreading how you titrated. Based on what I read, it looks like this (I'm filling in dates and doses from what I assume you meant):

1st shot Wed Oct. 7th 2026: 2.5mg

2nd shot Mon Oct. 12th 2026: 6mg

3rd shot Sat Oct. 17th 2026: 10mg

4th shot Thu Oct. 22nd 2026: 7.5mg

5th shot Sun Oct. 25th 2026 : 11.25mg

Does that match? Roughly? That strikes me as a fairly rapid titration, particularly since the medication level takes a few weeks to level out in the body. I'm glad you aren't having any bad effects. My own view is that going up more slowly is the wiser path. That said, it's your body, and I may also be misinterpreting what you're telling me.
 
Ramping doses up that quickly carries a fairly high chance of triggering severe side effects that won't resolve fast. Many GLP side effects are merely uncomfortable or irritating rather than dangerous — but vomiting and severe diarrhoea are dangerous. Dehydration from vomiting is the top reason people land in the ER or hospital after starting GLP drugs; given the week-long half-life, a week of vomiting has quite good odds of putting you in hospital, and waiting too long can let dehydration progress to renal failure, which could kill you outright or leave you with chronic renal failure. Even following the standard dose-escalation schedule this happens, and fast increases like that raise the odds a lot. If you must go up quickly, smaller and more frequent doses are much safer — but before attempting anything of the sort you need to check glp1plotter and grasp the adverse effects of these drugs.

Also, in this case the OP is diabetic. I don't know which diabetic medication he takes, but it's unlikely to be nothing. GLP drugs usually don't cause hypoglycemia, but that definitely isn't true when other blood-sugar-lowering drugs are taken at the same time. Cranking doses up fast in that situation is extra dangerous.

You are obviously free to decide what doses of what drugs you put in your body, and I think your approach is dangerous — I went from 0mg to 15mg of tirzepatide in a month, but I did have a very good understanding of the drug's pharmacokinetics first. Still, if advising or suggesting doses to others, I do think you need to make sure you understand the issues and risks involved first.
 
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