Turbo-Farmer said:
waltaaa said:
Over the last 4 weeks, fluid buildup has been showing up mainly in my lower body. It has gotten bad enough that I can't find the drive to get up and run, or even work out for the better. After 2IU worked well for me, I stayed at 3IU for a month, then titrated up to hgh 4IU. My blood levels look fine and gh levels are high too. To cut down on the fluid retention and return to normal, should I drop back to 3IU?
Separately, do we favor anterior posterior, Upper lower legs, or just do whatever you want?
The body releases growth hormone in pulses across both daytime and nighttime. With HGH, igf stays persistently elevated, and that can trigger side effects besides holding onto fluid — fluid retention itself being a diabetes symptom. Have your A1c tested.
What you're going through is exactly why a number of people choose secretagogues instead.
I hope these effects are short-lived and go away once you bring your dose down.
Get your labs done, no way around it!!!!
Your dosing decisions need to be guided by igf and igf z score, not by iu.
What is a tolerable amount for one individual may trigger adverse reactions and/or lasting harm in another.
Keep a close eye on fasting insulin — when it runs high, cardiac issues and similar problems can follow.
If you set exogenous HGH (synthetic Human Growth Hormone) next to Tesamorelin where insulin resistance is concerned, Tesamorelin comes out substantially safer and much less prone to disrupting blood sugar regulation.
Yes, both raise circulating growth hormone (GH) and IGF-1 — but the way each one transmits that signal to your cells is what separates them for glucose metabolism.
1. Exogenous HGH: Direct Antagonist to Insulin
When you inject HGH directly, you sidestep the body's own regulatory machinery. Growth hormone does support fat loss and muscle retention, yet GH is fundamentally an insulin antagonist:
Glucose Uptake Falls: HGH reduces how well skeletal muscle and peripheral tissues pull glucose out of the bloodstream.
Free Fatty Acids Surge: Through rapid lipolysis (breakdown of stored fat), fatty acids flood the bloodstream, and that directly disrupts insulin signaling at the cellular level.
Risk: Large or prolonged exogenous HGH dosing often produces higher fasting blood glucose, rising HbA1c, and greater insulin resistance.
2. Tesamorelin: Pulsatile Release & Visceral Fat Reduction
Tesamorelin belongs to the GHRH (Growth Hormone-Releasing Hormone) analog class. Instead of delivering GH straight into your system, it prompts your pituitary gland to make and secrete its own GH.
Natural Pulses Stay Intact: Operating through the body's own feedback loops, GH arrives in physiological pulses instead of one steady, unnaturally elevated wave. That pulsed pattern places far less strain on insulin sensitivity.
Glucose Impact Stays Neutral: Clinical trials — among them studies conducted specifically with type 2 diabetic patients — indicate that Tesamorelin by and large produces no meaningful adverse effect on glucose tolerance or fasting insulin levels.
Goes After Visceral Adipose Tissue (VAT): Tesamorelin was purpose-built and FDA-approved for shrinking deep visceral fat (the abdominal fat wrapped around internal organs). Since visceral fat is a primary force behind systemic inflammation and insulin resistance, lowering VAT frequently brings downstream gains in overall metabolic health.
