Appetite suppression that came out of nowhere

[Researcher6076]

I began losing weight on Sema, moved to Tirz, and these days I stack Tirz with Reta. Since I'm getting close to my target, I'm reducing the dose gradually, and the Tirz + Reta combo is helping me reshape how I relate to food. For roughly 2 months I've stayed at 2mg Tirz plus 4mg Reta, and I've been feeling ready to step down.

Over the past 2 weeks, though, my appetite has been crushed to an unusual degree — as if I'd doubled my dose! There's no nausea, no vomiting, no constipation, no diarrhea. Nothing unpleasant at all, only this intense appetite suppression. Eating has become something I have to push myself to do.

One thing that might explain it: not long ago I mixed up a fresh vial of Tirz. Then again, trying to recall the timing now, I can't actually confirm the appetite suppression lined up with the new vial. It's possible the older vial had lost potency while sitting in my fridge — but it never seemed to me like that vial had stopped working. Or maybe the new vial contained more mg than the label says.

Those are just my leading theories. What I really want to know is whether anyone else here has run into appetite suppression on SG1s that had no clear explanation.

 

[CNCCurrency]

Could it be an overfill, so your dose came out stronger than you expected?

 

[lessthanhalf]

Before anything else, verify your calculations. No matter how experienced you are, a simple mistake in working out dilutions or doses can happen so easily. Try checking once more, and then a third time, using a peptide calculator site. Do that for each of the peptides. Could a reta vial have been swapped with a tirz vial?

If not, there are no clear explanations. Should you have some from another batch, give that a go. Usually, once you have lost weight and are approaching your target, hunger ought to rise rather than fall. Since you mention it has been 2 weeks, a virus is unlikely to be the cause.

If no alternative tirz batch is available, a lower dose could be worth trying, as it may act differently, though that does not really add up: even if the dose were off by 100%, using 4 versus 2mg of tirz weekly, on top of 4mg of reta, sits near the threshold where the change might not be noticeable at all. A reta dose off by 100% ( 8mg rather than 4 ) would be clear, but with the same batch/vial/dilution, that would be almost impossible.

 

[Researcher6076]

Thanks for the reply and the suggestions — they were thoughtful. Every one of those possibilities seems plausible to me, 100%. The vial is new, and it comes from a new lot. At this point, almost nothing can be ruled out. Assuming the mg labels on the vials are accurate, my math checks out. Since everything runs through excel, the math itself isn’t the issue; the likely culprit would be me entering a number wrong, and I’ve already double checked that. It’s also possible I messed up once while drawing into a syringe. Still, this has been going on for a couple of weeks, and because my doses split the weeks, I’ve taken at least three doses. Something definitely seems off. This mystery may go unsolved, LOL. Yesterday I skipped my doses, and I’m planning to start again the day after tomorrow.

lessthanhalf said:

Before anything else, verify your calculations. No matter how experienced you are, a simple mistake in working out dilutions or doses can happen so easily. Try checking once more, and then a third time, using a peptide calculator site. Do that for each of the peptides. Could a reta vial have been swapped with a tirz vial?

If not, there are no clear explanations. Should you have some from another batch, give that a go. Usually, once you have lost weight and are approaching your target, hunger ought to rise rather than fall. Since you mention it has been 2 weeks, a virus is unlikely to be the cause.

If no alternative tirz batch is available, a lower dose could be worth trying, as it may act differently, though that does not really add up: even if the dose were off by 100%, using 4 versus 2mg of tirz weekly, on top of 4mg of reta, sits near the threshold where the change might not be noticeable at all. A reta dose off by 100% ( 8mg rather than 4 ) would be clear, but with the same batch/vial/dilution, that would be almost impossible.

Thanks for the reply and the suggestions — they were thoughtful. Every one of those possibilities seems plausible to me, 100%. The vial is new, and it comes from a new lot. At this point, almost nothing can be ruled out. Assuming the mg labels on the vials are accurate, my math checks out. Since everything runs through excel, the math itself isn’t the issue; the likely culprit would be me entering a number wrong, and I’ve already double checked that. It’s also possible I messed up once while drawing into a syringe. Still, this has been going on for a couple of weeks, and because my doses split the weeks, I’ve taken at least three doses. Something definitely seems off. This mystery may go unsolved, LOL. Yesterday I skipped my doses, and I’m planning to start again the day after tomorrow.

 

[lessthanhalf]

It's conceivable that a manufacturing mistake occurred and the vial's contents don't match the label, but I'd still bet on a triple-check uncovering a discrepancy — though it sounds like you've already looked into this quite thoroughly. For the effect you're describing, the dose would need to be wrong by at least a factor of 2, or the substance would have to be an entirely different compound. What genuinely surprises me is how seldom this happens. These vendors aren't pharmaceutical companies with extensive regulations, inspection regimes, and an absolutely essential obsessive safety-first culture. No matter how badly they screw up, they can't be sued or hit with manslaughter or assault charges. As far as I can tell, the only pressures producing any quality control are their own personal ethics (which seems like it could be an unreliable mechanism) and a desire to avoid bad posts on forums like this one or getting truly exposed by test results proving serious dosing or labelling errors. Given how many alternative options exist, the sales lost from such incidents could be enormous — millions, easily.

Was this a new vendor for you? Well known? Established for a while? With at least some third-party test results available somewhere online? If one vial in a batch is off, then it's reasonable to assume they all are, so switching to another vial from the same kit won't do any good.

A few cases have shown up on here — one where reta and semaglutide or tirz got mixed together somehow, which drew a lot of attention and led to a recall, and I came across a single case study of a woman in Italy who fell into a coma after an injection that turned out to be insulin from a vial labelled semaglutide. Though, as someone else here pointed out, that doesn't add up well, since there should have been far more cases rather than just one, and it raises questions about whether it was a deliberate substitution and possibly an attempted murder.

It's certainly possible this is simply an unusual response, a physiological quirk, where your hunger dropped for a while with no readily explainable cause.

The only way to be certain is to send a sample for testing, but buying another lot from a different source would almost certainly be cheaper and faster. Or you could just assume the dose is off and take a lower amount of it. Given the impact on appetite, it essentially can't be anything other than a glp drug. No other medications really produce such clear and substantial effects on appetite.

 

[Foggy-Hollow]

Researcher6076 said:

Thanks for the reply and the suggestions — they were thoughtful. Every one of those possibilities seems plausible to me, 100%. The vial is new, and it comes from a new lot. At this point, almost nothing can be ruled out. Assuming the mg labels on the vials are accurate, my math checks out. Since everything runs through excel, the math itself isn’t the issue; the likely culprit would be me entering a number wrong, and I’ve already double checked that. It’s also possible I messed up once while drawing into a syringe. Still, this has been going on for a couple of weeks, and because my doses split the weeks, I’ve taken at least three doses. Something definitely seems off. This mystery may go unsolved, LOL. Yesterday I skipped my doses, and I’m planning to start again the day after tomorrow.

lessthanhalf said:

Before anything else, verify your calculations. No matter how experienced you are, a simple mistake in working out dilutions or doses can happen so easily. Try checking once more, and then a third time, using a peptide calculator site. Do that for each of the peptides. Could a reta vial have been swapped with a tirz vial?

If not, there are no clear explanations. Should you have some from another batch, give that a go. Usually, once you have lost weight and are approaching your target, hunger ought to rise rather than fall. Since you mention it has been 2 weeks, a virus is unlikely to be the cause.

If no alternative tirz batch is available, a lower dose could be worth trying, as it may act differently, though that does not really add up: even if the dose were off by 100%, using 4 versus 2mg of tirz weekly, on top of 4mg of reta, sits near the threshold where the change might not be noticeable at all. A reta dose off by 100% ( 8mg rather than 4 ) would be clear, but with the same batch/vial/dilution, that would be almost impossible.

Thanks for the reply and the suggestions — they were thoughtful. Every one of those possibilities seems plausible to me, 100%. The vial is new, and it comes from a new lot. At this point, almost nothing can be ruled out. Assuming the mg labels on the vials are accurate, my math checks out. Since everything runs through excel, the math itself isn’t the issue; the likely culprit would be me entering a number wrong, and I’ve already double checked that. It’s also possible I messed up once while drawing into a syringe. Still, this has been going on for a couple of weeks, and because my doses split the weeks, I’ve taken at least three doses. Something definitely seems off. This mystery may go unsolved, LOL. Yesterday I skipped my doses, and I’m planning to start again the day after tomorrow.

Check your COAs again—the fill volume is listed there. It's still a best guess statistically, but that's the closest thing we've got to an informed estimate.

Suppose the previous vial was just barely filled, while the new one is heavily over-filled—something a handful of vendors make a habit of—then the new vial would indeed hit much harder. Certain vendors overfill by a noticeable margin.

Because gray isn't tightly regulated, vial-to-vial consistency won't be great, particularly when you switch from one manufacturer to another, even if both are labeled the "same" mg.

 

[itsmenotyou]

Same here — that happens to me more often than not, honestly nearly every day. My dose is 1mg. The strange part? I'll make myself eat stuff I know I shouldn't. For example, someone gave me some chocolates from Australia recently, and even though I wasn't hungry, I knew how much I enjoy them, so I finished the whole lot. That means I could easily spend an entire day eating nothing but those chocolates. My diet really needs to be sorted out as soon as possible.