Any stack recommendations for adults 65 and older?

EAM9112

EAM9112

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Looking for a peptide stack for my parents to support general health. I was thinking Wolverine and something like adamax for cognitive function. Curious to hear everyone’s experiences.
 
Diamondd817 said:


KLOW & NAD+ might be a good start.

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Do you recommend a full SS-31 and Mots C protocol prior to NAD? I have never taken NAD myself but I have read it is most effective with the SS and Mots.
 
I am older than your parents. But you've got to move beyound age to their symptoms and goals. We're all indoviduals. Are they overweight? Cancer risks? chronic conditions? FWIW, here is my stack, but probably a nit more that your parents are looking for.

As with any stack, the foundation has to be sleep, nutrition, reisitance training. If you parents are doing those, some peptides and supliments might help them, towards their goals. But, they have to get those right as a foundation for peptides to help.



FunctionNameDoseFrequencyPatternMetabolicTirzepatideSC 1.5 mgWeekly (Sunday)ContinuousRetatrutideSC 1.5 mgWeekly (Wednesday)ContinuousMetforminPO 500 mgDailyContinuousGH axisIpamorelin + CJC‑1295 no‑DACSC 200 mcg + 200 mcgSun–Thu PM (fasted)12 weeks on / 6 weeks offTesamorelin + IpamorelinSC 2 mg + 200 mcgMon-Fri AM (fasting)Tissue repairGHK‑CuSC 1 mgDailyContinuousBPC‑157SC 200 mcg2× weeklyContinuousZinc PicolinatePO 50 mg3× weeklyContinuousAnti‑inflammatoryKPVSC 750 mcgDailyContinuousOmega‑3 PO DHA 900 mg; DPA 140 mgDailyContinuousImmune modulationThymosin‑α1SC 1.6 mgWeekly (Sunday)ContinuousLongevityEpitalon + Crystagen + PinealonSC 5 mg/day; 0.5 mg/day; 0.5 mg/dayDaily for 10 daysAnnually, other peptides paused except GLP‑1sProstrate supportProstamax (KEDP)SC 0.5 mg/dayDaily for 10 daysAnnuallyBeta SitosterolPO 250 mgDailyContinuousNeurotrophicSemaxIN 600 – 900 mcgDaily2-4 weeks on / 4–8 weeks offSleep supportL-GlycinePO 3000 mgDaily 1 hr before bedContinuousCellular energy & Brain supportNMN (β‑Nicotinamide Mononucleotide)PO 1000 mgDailyContinuousApigeninPO 200 mgDailyContinuousAcetyl‑L‑Carnitine (ALCAR)PO 1000 mgDailyContinuousBeta‑AlaninePO 3000 mgDailyContinuousCreatine HClPO 1500 mgDailyContinuous
 
Dr. Lee’s “Top 3 Peptides:”

BPC-157 – healing, gut repair, systemic anti-inflammatory.

Thymosin Alpha-1 – immune system support, anti-cancer, anti-viral.

Epitalon – longevity, gene regulation, pineal reset.

View: https://youtu.be/qnnq_-YL8dk?si=z2paSDTQwz9CWZ5j

Youtube AI said:


The video introduces Dr. Edwin Lee as a doctor who specializes in functional and regenerative medicine, with a strong focus on peptide therapy. He is also noted as a co-founder of the Clinical Peptide Society and has authored books on the topic, such as The Fountain of Youth with Peptides.

Epithalon: Dr. Lee describes this as his favorite bioregulator for longevity. It is naturally produced by the pineal gland, and as we age, its production decreases, causing cells to get stuck in the G2 phase of the cell cycle. Epithalon is said to turn on cell cycle activity, helping with self-replication, improving sleep by resetting melatonin production, and potentially reversing markers of biological aging (13:01 - 14:33; 23:45 - 24:12).

Thymosin Alpha-1: This peptide is highlighted for its role in supporting the immune system. As the thymus gland shrivels with age (a process known as immunosenescence), the immune system becomes less effective at fighting infections and cancer. Supplementing with Thymosin Alpha-1 is suggested to help rejuvenate immune function (4:02 - 5:13; 21:19 - 22:06).

BPC-157: Often referred to as the "Wolverine peptide," it is recommended for its powerful ability to reduce inflammation and accelerate the healing of tissues, joints, and tendons, which often become more susceptible to injury with age (7:13 - 11:07; 20:06 - 20:52).

Mitochondrial Peptides (MOTS-c and SS-31): For age-related energy decline caused by mitochondrial dysfunction, the video suggests MOTS-c to enhance mitochondrial performance and SS-31 to help maintain the structural integrity of the mitochondria (36:30 - 43:27).

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Attached are lifestyle modifications in place of (or in addition to) taking Epithalon to naturally increase levels of Epithalamin. PDF is by Google Gemini.
 
Calm Logic said:


Dr. Lee’s “Top 3 Peptides:”

BPC-157 – healing, gut repair, systemic anti-inflammatory.

Thymosin Alpha-1 – immune system support, anti-cancer, anti-viral.

Epitalon – longevity, gene regulation, pineal reset.

View: https://youtu.be/qnnq_-YL8dk?si=z2paSDTQwz9CWZ5j

Attached are lifestyle modifications in place of (or in addition to) taking Epithalon to naturally increase levels of Epithalamin. PDF is by Google Gemini.

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I do use the Epitalon reset myself. But the evidence is so thin it is almost non-existent. It has a good safety record, and some mechanistic plausibility, so heck, why not try it? But, no way it should be in the top 3.

Ta1, I agree has a real application for supporting aging. Most seniors have immune decline and once weekly 1.6mg Ta1 can likely help.

BPC-157 is worth considering, but only after a serious discussion around cancer risks. BPC-157 is absolutely contraindicated for active or recent malignancies and is highly cautioned for subjects at elevated cancer risk. Cancer risk increases with age.

KPV is almost a no brainer. It should be in the top 3 for sure. It is gentle, is widely used so we can infer safety, and it really helps with inflammation. Most seniors have inflammation.

I would consider a low dose of Retatrutide unless the subjects are below weight. Most seniors are no below weight. It has all kinds of protective effects, including reducing cholesterol due to glucagon activation; it literally encourages the body to burn lipids.

It isn’t a peptide, but unless contraindicated due to some individual condition, get them on 500 mg of Metformin. It helps stabilize blood sugar and it is an AMPK activator, so it improves mitochondrial function. (Google metformin for longevity and you will find mainstream research.)

And there are some simple supplements that almost every senior should be taking that support metabolism, energy and cognition: Omega-3, NMN, Apigenin, Acetyl‑L‑Carnitine, Beta‑Alanine, and Creatine HCl.

RE the video… it is frustrating as heck that videos and podcasts present information as authoritative when they clearly haven’t even done minimal study.
 
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