A New 5 Receptor Agonist

Seems intriguing, though an hour-long video isn’t something I’ll sit through. Which part would be best for us to focus on?
 
Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
 
Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
30% on average possibly.

Some individuals in Retatrutide trials dropped just 5% of their body weight even after close to 12 months of use. Surely they'd welcome a different choice!

And for certain people, 30% could still fall short. Suppose you begin at 300lb or more? You go on Reta, hit a plateau at 210, perhaps you'd prefer a more potent option to bring you down into the 100s.
 
Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
At times the upside comes in forms such as reduced adverse reactions, or improved management of insulin resistance. Still, no way am I sitting through a 60-minute video.
 
AI Summary:

This video covers the progression of GLP-1–class weight loss medications, moving from single → dual → triple → and now even 5-receptor agonists, along with the reasons this progression is significant.

The core concept

•Earlier medications acted on only 1 receptor (GLP-1) → assisted with appetite and blood sugar

•More recent ones act on several receptors simultaneously to boost outcomes

Triple agonists (the present “next step”)

•Activate 3 receptors: GLP-1 + GIP + glucagon

•Outcome: greater weight reduction and improved metabolic effects compared to earlier medications

•Illustration: retatrutide (still under investigation)

5-receptor agonists (the newest development)

•Investigational medications now act on 5 distinct pathways (incorporating things such as PPAR receptors)

•Aim:

-Even more fat loss

-Improved metabolic health (liver, insulin, etc.)

-Possibly fewer side effects by distributing the effects across pathways

Main point

•The change isn’t merely “stronger drugs”—it’s smarter, multi-pathway drugs

•The concept is: rather than forcing 1 system hard, gently affect several systems at once for superior results
 
Back when semaglutide was the only option, the idea of a triple G would have struck us as absurd. Drugs keep advancing, in my view, and this 5G strikes me as highly promising.
 
Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
Suppose your goal, as it is for me, is holding onto a 55% weight reduction. The target population for these medications is severe obesity (and, less so, moderate obesity). Within that severe group—BMI above 40 or even 45—even reta falls short, which explains why so many severe obesity patients here are stacking GLP's with amylin agonists. Right now, the sole legitimate options for severe obesity are tirzepatide or bariatric surgery. So a treatment that could lower the demand for fairly invasive surgery, or for unproven experimental cocktails, seems extremely valuable.
 
Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
For someone in my situation, it could be useful: I hit the ceiling on Mounjaro and plateaued, yet I'm still not at my target weight even with reta — I've got roughly 75lbs-85lbs left to shed.
 
On a personal level, improved weight loss medications are something I'm eager to see. Before this even becomes available, I'll already have reached my target. The man in the video was difficult for me to take seriously. Between his very fat face and his extremely puffy hands, I simply can't see him as a credible voice on weight loss. I stopped watching partway through.



Given the profits that weight loss drugs bring in, along with people consuming processed foods in record quantities, additional drugs and protocols reaching the market seems likely. Funding will keep pouring into R&D, and into the products those companies turn out. Even before GLP's, weight loss was already a Billion dollar industry. Books, classes, gyms, drugs, companies such as weight watchers, healthy food delivery services, home exercise equipment — there was no shortage of ways for us to part with our money. For every fat person, a weekly pill or shot is the ultimate fantasy.
 
Lovedog100 said:

On a personal level, improved weight loss medications are something I'm eager to see. Before this even becomes available, I'll already have reached my target. The man in the video was difficult for me to take seriously. Between his very fat face and his extremely puffy hands, I simply can't see him as a credible voice on weight loss. I stopped watching partway through.



Given the profits that weight loss drugs bring in, along with people consuming processed foods in record quantities, additional drugs and protocols reaching the market seems likely. Funding will keep pouring into R&D, and into the products those companies turn out. Even before GLP's, weight loss was already a Billion dollar industry. Books, classes, gyms, drugs, companies such as weight watchers, healthy food delivery services, home exercise equipment — there was no shortage of ways for us to part with our money. For every fat person, a weekly pill or shot is the ultimate fantasy.
Click to expand...
It really is wild that we're standing right at the edge of obesity becoming a chronic condition that can be cured. When the patents on these drugs run out and generics hit the shelves everywhere, being obese would basically turn into a choice.

Gen Z cares more about health than previous generations, and we've already watched fitness become a much bigger part of the culture. Just look at how many products now carry a "high protein" label to pull in people who work out.

Big food and the health industry are both in for some enormous changes.
 
Raidenfat2fit said:

Lovedog100 said:

On a personal level, improved weight loss medications are something I'm eager to see. Before this even becomes available, I'll already have reached my target. The man in the video was difficult for me to take seriously. Between his very fat face and his extremely puffy hands, I simply can't see him as a credible voice on weight loss. I stopped watching partway through.



Given the profits that weight loss drugs bring in, along with people consuming processed foods in record quantities, additional drugs and protocols reaching the market seems likely. Funding will keep pouring into R&D, and into the products those companies turn out. Even before GLP's, weight loss was already a Billion dollar industry. Books, classes, gyms, drugs, companies such as weight watchers, healthy food delivery services, home exercise equipment — there was no shortage of ways for us to part with our money. For every fat person, a weekly pill or shot is the ultimate fantasy.
Click to expand...
It really is wild that we're standing right at the edge of obesity becoming a chronic condition that can be cured. When the patents on these drugs run out and generics hit the shelves everywhere, being obese would basically turn into a choice.

Gen Z cares more about health than previous generations, and we've already watched fitness become a much bigger part of the culture. Just look at how many products now carry a "high protein" label to pull in people who work out.

Big food and the health industry are both in for some enormous changes.
Click to expand...
That idea really appeals to me. Tiny portions of highly processed, overpriced, bad-for-you food aimed at folks using GLP-1s
 
Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
Me, for instance. My starting point was 334 ... a 30% drop lands me at 234. That's still obese. To get where I need to be, I'd have to shed roughly 50% of what I weighed at the start.

And people don't all respond identically to every receptor ... having choices can only help.
 
From what I can work out, the majority of those high protein items that have hit the shelves lately aren't really all that good for you — they're basically ultra processed foods with a bit more protein packed in. So my guess is they could keep you feeling full a little while past when the regular kind would, and that's really all there is to it.
 
cheaperseeker said:

AI Summary:

This video covers the progression of GLP-1–class weight loss medications, moving from single → dual → triple → and now even 5-receptor agonists, along with the reasons this progression is significant.

The core concept

•Earlier medications acted on only 1 receptor (GLP-1) → assisted with appetite and blood sugar

•More recent ones act on several receptors simultaneously to boost outcomes

Triple agonists (the present “next step”)

•Activate 3 receptors: GLP-1 + GIP + glucagon

•Outcome: greater weight reduction and improved metabolic effects compared to earlier medications

•Illustration: retatrutide (still under investigation)

5-receptor agonists (the newest development)

•Investigational medications now act on 5 distinct pathways (incorporating things such as PPAR receptors)

•Aim:

-Even more fat loss

-Improved metabolic health (liver, insulin, etc.)

-Possibly fewer side effects by distributing the effects across pathways

Main point

•The change isn’t merely “stronger drugs”—it’s smarter, multi-pathway drugs

•The concept is: rather than forcing 1 system hard, gently affect several systems at once for superior results
Click to expand...
I'm keeping my fingers crossed that this won't mean 5 times the adverse effects.
 
For the people this is aimed at, it's a thrilling development, but in my view a triple agonist deserves more extensive research before we jump to five. We're in a marathon here, not a sprint, and at times I feel the medical field rushes ahead because of financial incentives or branding.

That's just my two cents.
 
deleted.user.16 said:

Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
30% on average possibly.

Some individuals in Retatrutide trials dropped just 5% of their body weight even after close to 12 months of use. Surely they'd welcome a different choice!

And for certain people, 30% could still fall short. Suppose you begin at 300lb or more? You go on Reta, hit a plateau at 210, perhaps you'd prefer a more potent option to bring you down into the 100s.
Click to expand...

Take something like Retatrutide: its typical weight loss outcomes don't occur in isolation. These medications amplify the body's metabolic signaling—they don't bulldoze over it.

When a person drops only 5%, the usual explanation isn't insufficient drug potency. More often, it points to a deeper metabolic issue at play.

Factors such as insulin resistance accompanied by high fasting insulin, ongoing inflammation (for example, raised CRP), thyroid problems, and hormone imbalances—particularly among women—can each dampen how well someone responds. The drug isn't the problem... the underlying foundation is broken.

Beyond that, the way you back up the medication is equally important.

Undereat or starve yourself, and your body will slow things down and push back.

Skimp on protein, and you shed lean tissue rather than fat.

Skip resistance training, and you give your body no incentive to hold onto muscle or keep metabolism elevated.

Too little daily movement can wipe out a calorie deficit.

So simply adding a more powerful multi-receptor agonist doesn't automatically solve the issue.

If someone begins at 300+ pounds and reaches 210, that isn't a failure—it's an enormous metabolic transformation. When things plateau at that point, it generally signals the body is guarding that set weight, and there's still physiology and habits to work on, rather than just pushing the dose higher.

The real question is: what's stopping the body from responding completely, and are we truly meeting the medication halfway?
 
MsGizmo said:

Vash_ said:

Seriously, why bother? Reta has already been demonstrated to reduce body weight by 30% in people. That alone is absurd. Who actually requires a treatment that works even better?
Click to expand...
Me, for instance. My starting point was 334 ... a 30% drop lands me at 234. That's still obese. To get where I need to be, I'd have to shed roughly 50% of what I weighed at the start.

And people don't all respond identically to every receptor ... having choices can only help.
Click to expand...
Your point makes sense to me, and I’m with you that having additional choices is beneficial.

Still, that 30% figure from the Retatrutide trials shouldn’t be viewed as a hard limit. It reflects an average generated under a highly controlled protocol. In those studies, everyone follows a fixed titration schedule, and the outcomes are measured against that, rather than against individuals who are actively fine-tuning their approach.

On top of that, the trials don’t address the fundamentals in any meaningful way. They aren’t designed around staying at the smallest dose that works, getting sufficient protein, doing resistance training multiple times per week, prioritizing sleep, keeping stress in check, or recalculating intake as weight comes off.

That gap is where many people fail to get everything they could out of the process.

In practice, once the medication is paired with those habits, it’s possible to exceed the trial averages by a wide margin, because the focus shifts to improving metabolic health instead of depending solely on the drug.

So yes, if a person begins at 334 and hopes to lose more than 30%, that’s completely reasonable. The issue isn’t necessarily that a stronger agent is required; often it comes down to whether the basics are truly in order.
 
I doubt it will make it anywhere near trial approval — the danger profile is just too large. Amylin slows digestion down even further, wipes out cravings (that part is good) and leaves you feeling stuffed for hours on end, which raises the odds of heart burn, plus you end up eating far below what your body actually needs to stay healthy. Then Calcitonin enters the picture and cuts the brain off entirely from hunger signals. When GLP-1's help with weight loss and mental health, I'm all for them, but I strongly believe in pairing any GLP with real lifestyle changes — planning meals, eating on a steady schedule, building habits you can actually sustain so the weight stays off. Shutting hunger out of the mind completely while cutting food intake is a wrecking ball waiting to happen.
 
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