A GLP-1 you swallow, made in China?

Just A Cat

Just A Cat

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This article showed up in my feed just now.

www.scmp.com/news/china/science/article/3364322/chinese-team-aims-put-smart-diabetes-probiotic-us-shelves-within-2-years

The Chinese team's aim: a 'smart' diabetes probiotic on US shelves within 2 years

Named Gift, this engineered probiotic senses high blood sugar and releases the glucose-lowering hormone GLP-1 on its own

(AI Summary) What the article covers is a major breakthrough from Chinese researchers based at East China Normal University in Shanghai. Their engineered "smart" oral probiotic, called GIFT (Glucose-intelligence Function and Response), is built to detect high blood sugar and then release the glucose-lowering hormone GLP-1 by itself.

As most people here already know, GLP-1 is something the gut produces naturally. What the researchers did was modify an E.coli strain so it can flip a protein gene between on and off states in response to high sugar levels. The protein that gets produced when the sugar signal is high is a GLP-1.

Honestly the possibilities are hard to take in.

Tracked down a study.

Glucose-responsive probiotics for glycemic modulation in mice and monkeys.
 
A 2 year timeline sounds a bit optimistic, given that so far there are only animal studies and not even phase 1 human trials. The plan appears to be developing it as a "drug" instead of an over the counter probiotic , which if it works is probably a lot safer than just letting everyone go crazy with it. Then again it does not sit neatly inside the standard drug category, so approval could throw up extra issues even if the human testing all goes well.

Controlling the dose of drug/peptide/protein that the bacteria release is hard to picture. Surely it would come down to how many bacteria made it past the stomach acid, plus whatever regulatory system is built into the bacteria itself — hypoglycemia is not something you want it triggering. Unfortunately the paper is not something I can find, only the abstract, so the details are out of reach.
 
lessthanhalf said:

A 2 year timeline sounds a bit optimistic, given that so far there are only animal studies and not even phase 1 human trials. The plan appears to be developing it as a "drug" instead of an over the counter probiotic , which if it works is probably a lot safer than just letting everyone go crazy with it. Then again it does not sit neatly inside the standard drug category, so approval could throw up extra issues even if the human testing all goes well.

Controlling the dose of drug/peptide/protein that the bacteria release is hard to picture. Surely it would come down to how many bacteria made it past the stomach acid, plus whatever regulatory system is built into the bacteria itself — hypoglycemia is not something you want it triggering. Unfortunately the paper is not something I can find, only the abstract, so the details are out of reach.
Click to expand...
In the colon the only "sugars" present would be monosaccharides released through microbial fermentation. I'm curious whether it will show synergy alongside a high fiber intake?
 
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