220-310lbs, Wegovy trial, now Reta

tjtacoma

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Feb 22, 2026
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Hi everyone,

The best place to share my GLP1's experiences, and hopefully to find advice on moving forward, is what I've been hunting for.

For context, weight has been a struggle my whole life and bouncing between 220lbs - 310lbs has been the story as a M standing 6'1''. Getting into a clinical trial for Wegovy happened some 2.5 years back and 290lbs turned into 200lbs, great news, but a lot of muscle went in the process, not just fat. Pushing the dose higher was what the clinicians kept pretty pushily encouraging, even with negitive effects starting to appear. Worse still, when the study ended 65lbs came back in about 6 months. What I feel I need is something keeping me on track long term, but at a lower dosage, hopefully.

Whether I qualify for a retatrutide study was just screened, and a reply supposedly comes soon.

Long story longer... what I can share from being pushed onto a needlessly high dose far too quickly is why I'm here, plus some advice on balancing potential medications going forward, hopefully.
 
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