Tolerance reset

Gearhead73

Gearhead73

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For someone taking high doses (12mg+/wk), how long would a full tolerance reset take, in your estimation?

If I were in that position, my thinking is that once I hit my goal weight, I'd want to try bringing my tolerance back down to a starting dose. Going cold turkey would likely make it hard to avoid regaining a lot of weight, but if you could keep things steady for a few months... your maintenance dose could end up much lower and cheaper.

My guess (with nothing to back it up) would be 3 months.
 
GLPs don't function that way.

Once you hit your goal, you could attempt stepping the dose down the same way you stepped it up, and you might end up on a smaller maintenance dose — but nothing is being "reset," and you shouldn't count on 2mg holding you in maintenance. If it turns out that dose does work for you, great! Still, the only way to find out is to keep an eye on your weight and how you feel while you taper down.
 
Gearhead73 said:


How long do you think it would take for someone on high doses (12mg+/wk) to completely reset their tolerance?

I would think that if I was at those dosages I would want to attempt resetting my tolerance to a starting dose after I reached my goal weight. It would probably be difficult to not gain a lot of weight back after going cold turkey, but if you could hold the fort down for a few months... you could have a much lower/cheaper maintenance dose.

My guess (based on nothing) would be 3 months.

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Take a look at what I wrote below as well. She's correct — there's no resetting and beginning again. You'd probably hurt yourself in a few ways, and gaining weight is one of them. Compared to compounded, this stuff really isn't costly at all. You're not able to say where you're buying from at the moment, but is it a US based source or GB's?

ladyj779 said:

GLPs don't function that way.

Once you hit your goal, you could attempt stepping the dose down the same way you stepped it up, and you might end up on a smaller maintenance dose — but nothing is being "reset," and you shouldn't count on 2mg holding you in maintenance. If it turns out that dose does work for you, great! Still, the only way to find out is to keep an eye on your weight and how you feel while you taper down.
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My dose was 10mg and my wife's is 12mg. At 10mg I reached goal (down 60lbs) and began tapering to 8mg, then 6mg, and I gave 4mg a try. 4mg was awful — I felt hungry a lot and the fullness wasn't the same. For maintenance I landed on 6 and 8mg. My weight is stable and that stubborn subcutaneous belly fat is gradually going away.
 
What I genuinely can't wrap my head around is why folks are so against using a supplement that massively betters their health across a whole range of measurable outcomes, yet they'll 💯 swallow a pile of useless vitamins daily that almost always run more money for nothing or next to nothing

Me, I just do both 😂😂😂
 
Right now my stack is 3mg reta, 10mg tirz, and .25mg sema. I'll likely keep titrating upward a few more times, switching between them. Once I'm happy with where I am, I'll do what bnlfl did and titrate back down, as much as I'm able. As for the expense, the glps run me around 5 bucks a week. Honestly that number is probably too high — I just don't feel like crunching the numbers at the moment 😂
 
BNLFL said:

Take a look at what I wrote below as well. She's correct — there's no resetting and beginning again. You'd probably hurt yourself in a few ways, and gaining weight is one of them. Compared to compounded, this stuff really isn't costly at all. You're not able to say where you're buying from at the moment, but is it a US based source or GB's?



My dose was 10mg and my wife's is 12mg. At 10mg I reached goal (down 60lbs) and began tapering to 8mg, then 6mg, and I gave 4mg a try. 4mg was awful — I felt hungry a lot and the fullness wasn't the same. For maintenance I landed on 6 and 8mg. My weight is stable and that stubborn subcutaneous belly fat is gradually going away.
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Since you're in maintenance now, has your tolerance pretty much held steady?
 
ladyj779 said:

What I genuinely can't wrap my head around is why folks are so against using a supplement that massively betters their health across a whole range of measurable outcomes, yet they'll 💯 swallow a pile of useless vitamins daily that almost always run more money for nothing or next to nothing

Me, I just do both 😂😂😂
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A friend of mine keeps pestering me about when I plan to quit using GLP's sourced from "compounded pharmacies," because he's come across reports claiming those fall outside the FDA's scope.

I put on a very worried face and tell him I'll think it over after my current order runs out.. What he doesn't realize is how many decades' worth are sitting in the freezer.
 
BNLFL said:

Take a look at what I wrote below as well. She's correct — there's no resetting and beginning again. You'd probably hurt yourself in a few ways, and gaining weight is one of them. Compared to compounded, this stuff really isn't costly at all. You're not able to say where you're buying from at the moment, but is it a US based source or GB's?



My dose was 10mg and my wife's is 12mg. At 10mg I reached goal (down 60lbs) and began tapering to 8mg, then 6mg, and I gave 4mg a try. 4mg was awful — I felt hungry a lot and the fullness wasn't the same. For maintenance I landed on 6 and 8mg. My weight is stable and that stubborn subcutaneous belly fat is gradually going away.
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What was your length of time on the 10mg dose prior to making the choice to go down in titration?
 
Adding my agreement here. Actually, when you quit a GLP-1, the dose you need once you start again tends to be higher.

Broadly speaking, you have 2 paths: track calories (if losing weight is your only aim) or stack a different -tide on top.
 
Gearhead73 said:


How long do you think it would take for someone on high doses (12mg+/wk) to completely reset their tolerance?

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Just sharing my experience: a 4-week break did nothing for me in terms of resetting. It wasn't really meant as a reset anyway — my wife and I were on a month-long trip through several Asian countries, and I simply didn't want the headache of hauling vials and syringes across one border after another. As I figured, I felt hungry the entire month. I ate enormous amounts, loading up on carbs and sweets, yet logging 20k steps daily stopped the scale from moving much. All told, I came back up just 2 pounds. Then, restarting my usual Tirz dose, the appetite suppression I got was exactly the same as it had been before the trip. So nothing fundamental about my tolerance or my body had shifted across those 4 weeks. Still, I suspect that staying off Tirz for something like a year would likely deliver a bigger change. I admit I'm going purely on intuition here, with zero science behind it.

The real takeaway for me: steady exercise, even at a modest level, can matter more for weight control than you'd think.
 
There's a woman I know whose doctor put her on Ozempic. She'd been stuck at a plateau for more than 1 year while on 2.0 mg. After she lost her insurance coverage, she put 30 lbs back on in 4 mos. She managed to buy some 2mg pens paying full price, and gave herself a 2mg shot. The next day she wound up in the hospital with severe vomiting. What she'd overlooked was titrating back up with the new pens. Once she lost coverage, she regained weight, then shed less than she'd put back on before hitting yet another plateau.
 
Gearhead73 said:


How long do you think it would take for someone on high doses (12mg+/wk) to completely reset their tolerance?

I would think that if I was at those dosages I would want to attempt resetting my tolerance to a starting dose after I reached my goal weight. It would probably be difficult to not gain a lot of weight back after going cold turkey, but if you could hold the fort down for a few months... you could have a much lower/cheaper maintenance dose.

My guess (based on nothing) would be 3 months.

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The reason you went on them in the first place matters a great deal.

Ask yourself: even after reaching goal weight, was food the center of your life before?

Planning meals, cooking, constantly wondering what you'd eat next?

Being free of that food noise, of living without those obsessions, is worth the cost of staying on.

I've seen this "cycling" work for some people, but that's the exception rather than the rule.

So if you add up all the benefits, which one would you be okay losing?

Weight loss

  1. food noise mitigation
  2. Heart and liver help
  3. to name a few..
 
I began on semaglutide, but eventually stalled out. After losing coverage, I moved to a compound pharmacy version of tirz, and later to grey tirz. The bulk of my weight loss came from tirzepatide. I ramped up quickly to 15 mg and never experienced any bad sides from it. Once I plateaued at 15mg, I still had roughly 20lbs left to lose. I raised the dose to 20mg, which got me another 10 lbs. From there I went to 20 mg every 6 days, then every 5 days. At last I made it to my goal weight!!

For maintenance I began at 12 mg every 7 days. That worked well initially. I also tried adding Mazdutide and Reta at one point. In time, 10 mg tirz did the job fine. Then I gradually began dipping below my goal weight. I have been steadily reducing my dosage to hold at the goal weight. Right now I'm at 5mg every 10 days. I do not want to stop taking tirzepatide!!!

I want to keep all the health benefits.

Once I got within 20 lbs of my goal weight, I noticed I was losing muscle mass, so I added lifting on top of my existing cardio routine. I got hooked on lifting. Not only did my muscle mass go up, but I think my metabolism went up too. I believe that faster metabolism is what made the lower glp-1 dose necessary.
 
swimmer said:

I began on semaglutide, but eventually stalled out. After losing coverage, I moved to a compound pharmacy version of tirz, and later to grey tirz. The bulk of my weight loss came from tirzepatide. I ramped up quickly to 15 mg and never experienced any bad sides from it. Once I plateaued at 15mg, I still had roughly 20lbs left to lose. I raised the dose to 20mg, which got me another 10 lbs. From there I went to 20 mg every 6 days, then every 5 days. At last I made it to my goal weight!!

For maintenance I began at 12 mg every 7 days. That worked well initially. I also tried adding Mazdutide and Reta at one point. In time, 10 mg tirz did the job fine. Then I gradually began dipping below my goal weight. I have been steadily reducing my dosage to hold at the goal weight. Right now I'm at 5mg every 10 days. I do not want to stop taking tirzepatide!!!

I want to keep all the health benefits.

Once I got within 20 lbs of my goal weight, I noticed I was losing muscle mass, so I added lifting on top of my existing cardio routine. I got hooked on lifting. Not only did my muscle mass go up, but I think my metabolism went up too. I believe that faster metabolism is what made the lower glp-1 dose necessary.
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Sounds like something straight out of the LadyJ, BNLFL playbook — "That's How You Do It!!".... 👍
 
ladyj779 said:

What I genuinely can't wrap my head around is why folks are so against using a supplement that massively betters their health across a whole range of measurable outcomes, yet they'll 💯 swallow a pile of useless vitamins daily that almost always run more money for nothing or next to nothing

Me, I just do both 😂😂😂
Click to expand...

Unwanted effects. Expense. One more thing added to the weekly routine that has to be kept track of.

A few people decide the trade-off pays off, while for others the equation just doesn't add up. 🤷‍♀️
 
Foggy-Hollow said:

Unwanted effects. Expense. One more thing added to the weekly routine that has to be kept track of.

A few people decide the trade-off pays off, while for others the equation just doesn't add up. 🤷‍♀️
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Honestly, I feel like I've come out ahead — the only things I've experienced are pounds coming off and better health across the board, plus a general sense of being happier.

As for what it costs me, that would be buying new clothes.

My days are packed from morning to night, so for years now I've kept everything on a Google calendar with notifications turned on. Peps are simply one more entry on that list.

There will always be a reason someone can find to put their own health and well-being last. What people need to hear is that they are absolutely worth prioritizing.
 
Foggy-Hollow said:

Unwanted effects. Expense. One more thing added to the weekly routine that has to be kept track of.

A few people decide the trade-off pays off, while for others the equation just doesn't add up. 🤷‍♀️
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In my case (and probably plenty of others?) the unwanted effects fade away... what's left is simply the peptide pastime itself....a "pastime that pays off"... 😎 👍
 
ladyj779 said:

Right now my stack is 3mg reta, 10mg tirz, and .25mg sema. I'll likely keep titrating upward a few more times, switching between them. Once I'm happy with where I am, I'll do what bnlfl did and titrate back down, as much as I'm able. As for the expense, the glps run me around 5 bucks a week. Honestly that number is probably too high — I just don't feel like crunching the numbers at the moment 😂
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LOL - MATH IS HARD! @woundcarping I will NEVER let this go! 🤣 🤣

Lady J - what's your target amount of weight to shed? I'm 100% with you on the new wardrobe! Here in Los Angeles it just dipped under 72 degrees, so out came my treasured DULUTH double-lined cargo jeans from last year - no way am I freezing. I pulled them up, zipped them, and down they went. My feelings are VERY conflicted...
 
ladyj779 said:

Honestly, I feel like I've come out ahead — the only things I've experienced are pounds coming off and better health across the board, plus a general sense of being happier.

As for what it costs me, that would be buying new clothes.

My days are packed from morning to night, so for years now I've kept everything on a Google calendar with notifications turned on. Peps are simply one more entry on that list.

There will always be a reason someone can find to put their own health and well-being last. What people need to hear is that they are absolutely worth prioritizing.
Click to expand...
There are several obstacles I could name, but honestly the one that matters most in my case is adverse effects. Right now I'm easing back onto tirz with tiny doses.

Once SI began intruding and that isn't typical for the kind of MDD I usually have, sema turned into an absolute no.

ladyj779 said:

Honestly, I feel like I've come out ahead — the only things I've experienced are pounds coming off and better health across the board, plus a general sense of being happier.

As for what it costs me, that would be buying new clothes.

My days are packed from morning to night, so for years now I've kept everything on a Google calendar with notifications turned on. Peps are simply one more entry on that list.

There will always be a reason someone can find to put their own health and well-being last. What people need to hear is that they are absolutely worth prioritizing.
Click to expand...
No sarcasm intended: Share the encouragement and the love. Big Pharma should go bankrupt. People NEED to look after themselves better. Just try not to frame it as somebody failing to care for themselves because they aren't on a Glp-1. At times it's a hard no that our bodies hand us.
 
Foggy-Hollow said:

There are several obstacles I could name, but honestly the one that matters most in my case is adverse effects. Right now I'm easing back onto tirz with tiny doses.

Once SI began intruding and that isn't typical for the kind of MDD I usually have, sema turned into an absolute no.


No sarcasm intended: Share the encouragement and the love. Big Pharma should go bankrupt. People NEED to look after themselves better. Just try not to frame it as somebody failing to care for themselves because they aren't on a Glp-1. At times it's a hard no that our bodies hand us.
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Nowhere did I claim that skipping a glp means someone isn't looking after themselves.

I never even hinted at that, though you clearly read it that way.

A great many people fail to look after themselves or put their own physical and emotional health and well-being first. And they lean on a whole lot of excuses to justify it.

What you gave me were excuses tied to people not using glps. This has nothing to do with glps; it's about human nature.
 
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