lessthanhalf said:
I have said this before, but this is just not how any drug works. The response of the receptors to any agonist is a stretched out s shaped curve, and from what is known of the weight loss effects of retatrutide it is obvious that it works really very well even at 1mg, causing 9% weight loss over a year, about 18% at 4mg and 29% at 12mg. This weight loss pattern of reta at different doses places the effects at 4mg well into the rising area of that s shaped curve, not at the start of it, and places the effects at 1mg well into the rising area as well.
So there is no evidence that reta has any unique dose where the glucagon agonism starts working, it just does not make any sense in terms of basic pharmacology, and the data on weight loss strongly disagrees with it. The Doctor making the youtube videos , may well have experience and a medical degree but what he is saying is factually incorrect, and inconsistent with the well understood science of these drugs. He also supports using very low doses of GLP drugs, which again is not consistent with the research , where weight loss is clearly proportional to dose. I have no idea why he is supporting medical misinformation, he has no excuse based on lack of qualifications , and I think anyone presenting themselves as an expert should be required to make sure what they say is scientifically correct and if they have unorthodox beliefs they then need to provide extraordinary evidence to support their extraordinary claims.
The reason that this claim bothers me is that really low doses of reta like 1 or 2 mg might actually be one of the best options for people using these drugs who do not need to lose more than 10-15% of their bodyweight. These low doses are going to have significantly lower risks of bad side effects, and most likely lower risks of rare but severe side effects, which is important especially in the context of them being used in a group with generally lower long term health risks from being over weight or obese.
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