Thinking about switching to Sema from Reta

Damn I really want to thank ya'll for contributing on this thread, it means much to me because I learned more about GLPs than ever. Really, thank you.

I might just really use Tirz and maybe stack it with a low dose of reta, we will see!!
 
UpDownLeftRightAS* said:


I don’t really understand all the comments saying semaglutide is trash. It’s still a GLP-1 receptor agonist, and GLP-1 is one of the key mechanisms that also contributes to the effects of tirzepatide and retatrutide. Semaglutide was one of the first highly effective drugs in this class and is still a very effective medication.

Personally, I think it’s a great maintenance option. Beyond reducing food noise, it stopped me from biting my fingernails almost immediately after a lifetime of the habit. That’s obviously anecdotal, but a lot of my small compulsive habits and behaviors seemed to fade almost overnight and the GLP-1 seems to be the reason, not the GIP or Glucga add' ons to to the molecule.

If your goal is purely weight loss, current data suggest tirzepatide generally produces greater average weight loss than semaglutide, and many people find it to be a stronger appetite suppressant.

For my own maintenance protocol, I use semaglutide on Sundays and a small morning dose of retatrutide on Wednesdays, and that has worked well for me so far.

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I believe you wrote my post. I don't understand the Sema hate. Is it people who never used it? I agree it will be an awesome tool for long term maintenance and can stack with others like you are demonstrating.
 
UpDownLeftRightAS* said:


I don’t really understand all the comments saying semaglutide is trash. It’s still a GLP-1 receptor agonist, and GLP-1 is one of the key mechanisms that also contributes to the effects of tirzepatide and retatrutide. Semaglutide was one of the first highly effective drugs in this class and is still a very effective medication.

Personally, I think it’s a great maintenance option. Beyond reducing food noise, it stopped me from biting my fingernails almost immediately after a lifetime of the habit. That’s obviously anecdotal, but a lot of my small compulsive habits and behaviors seemed to fade almost overnight and the GLP-1 seems to be the reason, not the GIP or Glucga add' ons to to the molecule.

If your goal is purely weight loss, current data suggest tirzepatide generally produces greater average weight loss than semaglutide, and many people find it to be a stronger appetite suppressant.

For my own maintenance protocol, I use semaglutide on Sundays and a small morning dose of retatrutide on Wednesdays, and that has worked well for me so far.

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Semaglutide was the best weight loss drug ever when it first came out and is likely to get used a lot for a long time as it comes out of patent much sooner than the others in many places so will be cheaper. But if you are talking about grey GLP's using sema is almost never the best option.

But both reta and tirz are also GIP agonists, and GIP agonism counteracts some of the side effects from GLP-1 agonism, such as nausea, vomiting , food aversion and malaise. This is most of the reason for them having less of those side effects than sema.
 
lessthanhalf said:


Semaglutide was the best weight loss drug ever when it first came out and is likely to get used a lot for a long time as it comes out of patent much sooner than the others in many places so will be cheaper. But if you are talking about grey GLP's using sema is almost never the best option.

But both reta and tirz are also GIP agonists, and GIP agonism counteracts some of the side effects from GLP-1 agonism, such as nausea, vomiting , food aversion and malaise. This is most of the reason for them having less of those side effects than sema.

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True, but GIP and Glugn. are not stopping/ providing satiety to all the other little 'ticks' that was previously treated by benzos. As I understand it they are helping with metabolism, brown fat, and additional weight loss. The original GLP-1 molecule is doing the heavy lifting for a lot of other things as well (stopping biting my nails after a lifetime of excess, it's been two years now of that and other 'ticks' that dulled. I'll not risk those coming back). It's going to take years to fully realize what all these miracle molecules are really doing--I'm just happy the world even exists where we now have multiple choices to even compare 🙂
 
Spork said:


Absolutely fair statement, but I think the folks slamming semaglutide are going to be people like me who took it for weight loss, didn't have a great experience on it, weren't getting as much weight loss as they would like, increased the dose accordingly, and then fought brutal GI side effects.

Those same people would switch to tirzepatide and would find it to be both more effective and elicit fewer side effects.

In retrospect I wish when I started this whole journey I would have just started on tirzepatide or probably retatrutide.

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Completely valid, I'm happy we are in a situation where multiple life changing solutions exist as they now now. Brave new world 🙂
 
Might want to look into Cagri along with Reta instead of Sema. I haven't tried it myself since my Tirz x Reta stack is working well, but I've seen people say it kicks ass.
 
Throwfa said:


Might want to look into Cagri along with Reta instead of Sema. I haven't tried it myself since my Tirz x Reta stack is working well, but I've seen people say it kicks ass.

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Meh, I would wait until Eloralintide is available, over Cagri. Seems to lower heart rate and cleaner than cagri. Cagri is rough and many other anecdotes are similar. Used it for two weeks and it made me near bedridden with fatigue. Definitely suppressed appetite though.
 
Elora is better than cagri but at higher doses also has very high rates of fatigue as a side effect, at 3mg only 13%, but much higher once you get to 6mg or above.
 
Throwfa said:


Might want to look into Cagri along with Reta instead of Sema. I haven't tried it myself since my Tirz x Reta stack is working well, but I've seen people say it kicks ass.

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Whar does you stack look like of tirz and reta? Have you benefitted with both? How far apart do you take them? Im looking to do the same.
 
HappyBear said:


Whar does you stack look like of tirz and reta? Have you benefitted with both? How far apart do you take them? Im looking to do the same.

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After running with 2.5mg of tirz for a few months I started getting some food noise again. Instead of upping the dose I decided to add 1mg of reta to see what would happen. Had some lying around and figured why the hell not.

I'm currently on 2.5mg tirz + 2mg of reta. I track my rhr with a health tracker and definitely saw the reta get into action when upping the dose to 2mg.

So far so good, can recommend. More people have been running it successfully.
 
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