LongevitybroTX
Explorer
I suspect the “full stomach” side of this is being overthought, at least where tesamorelin and GLP-1s are concerned. Going without food before Tesa is not about an empty stomach or fast gastric emptying. What matters is not pinning right in the middle of a big insulin response to a meal. Insulin suppresses growth hormone output. That, rather than an empty gut, is why a fasted state gets mentioned for Tesa.
True, GLP1s delay gastric emptying, so food hangs about for longer. They also usually improve post-meal glucose control. Which means “my stomach is full from this GLP-1” does not automatically translate into “my insulin and glucose are still high enough to blunt tesamorelin.”
Someone with good insulin sensitivity will see glucose climb fast around a meal and settle back within an hour or two. If you are insulin resistant and that response looks more like rolling hills than peaks and valleys, sort that out before piling on Tesa. Being on a GLP1 means glucose and insulin will not climb as high and will fall back faster than they otherwise would. (So could a GLP-1 actually help Tesa work better and cut the ‘fasting’ window? I am no scientist - but maybe?)
(apologies for the shouty thread title)
True, GLP1s delay gastric emptying, so food hangs about for longer. They also usually improve post-meal glucose control. Which means “my stomach is full from this GLP-1” does not automatically translate into “my insulin and glucose are still high enough to blunt tesamorelin.”
Someone with good insulin sensitivity will see glucose climb fast around a meal and settle back within an hour or two. If you are insulin resistant and that response looks more like rolling hills than peaks and valleys, sort that out before piling on Tesa. Being on a GLP1 means glucose and insulin will not climb as high and will fall back faster than they otherwise would. (So could a GLP-1 actually help Tesa work better and cut the ‘fasting’ window? I am no scientist - but maybe?)
(apologies for the shouty thread title)