Switching from CJC/IPA to Tesamorelin and back

Shittersfull

Shittersfull

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I've come across several sources saying cjc/ipa needs to be cycled because of the ipa. I've also seen in quite a few places that either tesa or cjc can be run indefinitely. My question is: can I run cjc/ipa for a cycle, then go straight to tesa for my off-ipa cycle, then straight back to the cjc/ipa blend?

That would mean no breaks at all for the receptor that tesa and cjc hit.

It seems like this could be done, but I haven't found any definitive information on exactly this. And I'm not sure I want to be the experiment on this one.

Any insight out there?
 
Moving directly from CJC-1295 to Tesamorelin (and then back again) will not give you a genuine "off-cycle," since both compounds work through the very same GHRH pathway. If you want to keep results at their peak and preserve pituitary sensitivity, a real break requires stopping every GHRH and GHRP compound at the same time throughout your off-cycle window.

  • 5 Days On / 2 Days Off: Inject Monday through Friday and take the weekend off. This brief weekly pause helps guard against fast desensitization.

  • 12 Weeks On / 4 Weeks Off: Complete a 3-month cycle (with either CJC/Ipa or Tesamorelin), then follow it with a 4-week complete wash-out period.
 
The reasoning mostly makes sense, mate. Ipamorelin acts on the ghrelin receptor (GHS-R1a), whereas CJC and tesa both target the GHRH receptor. So if you switch to tesa by itself, you're giving the receptor that ipa uses a rest, but the GHRH side gets no break at all. For what it's worth, in the Egrifta trials tesa was given daily for 26 to 52 weeks straight and IGF-1 remained elevated, which suggests the GHRH side doesn't wear out fast. Still, if a proper full reset is what you're after, you'd stop everything for a few weeks, as JASYZ said. Either way, keep watching IGF-1 bloods, since they'll tell you more than any forum cycling chart.
 
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