Blvr7 said:
Smiter said:
Blvr7 said:
Smiter said:
Blvr7 said:
Hi everyone — I'm reaching out on behalf of my mom, who lives with a neurodegenerative condition: progressive supranuclear palsy, PSP. It falls under parkinsonism, and the underlying cause is tau protein accumulating in the brain. The main things she deals with are rigidity in the muscles, weakness, balance problems, incontinence, bradykinesia, difficulties with swallowing and her voice, plus frontal lobe shrinkage that brings memory loss and cognitive decline.
Gaining weight and building muscle is what she needs — losing weight is not a goal for her at all. From what I've dug up so far, the only candidates that seemed potentially workable were SS – 31 and Pinealon, though neither has much solid evidence for this kind of use. Cerebrolysin also crossed my radar, but with so little human data and the requirement for IV administration, it looks out of reach.
I want to do anything I can for her, yet money is tight — I'm her full-time caregiver and have no income to spend on kits. Keeping her injections and side effects to a minimum matters a lot to me. Any thoughts or personal experiences from people who know peptides well would mean the world — what might actually help her or support healing?
Has RI‐AG03, the ab76128 blocker peptide (ab211410), been something you've explored?
Hydrolysed whey, collagen, creatine, vitamin C, and Niacin.
One of my students based in Canada came up with an AI tool that identifies parkinson's via voice recognition. I assisted him with his research. While doing that, we explored possible routes for symptom treatment and how AI might play a role there. Here, the main hurdle is the difficulty surrounding IV dosage. Still, if nutrition supports muscle protein synthesis adequately, IGF-1 together with a myostatin inhibitor might at minimum slow the loss of muscle. Additionally, consider resistance bands and grippers, so that exercise can drive myokines such as BDNF. That's why Cerebrolysin performs well. Even so, BDNF and myokines originating from skeletal muscle do have a neurotrophic effect. That said, all of these only mitigate; none resolve. I'm sorry about your mom, and respect to you for caring for her. Respect!
,
I appreciate it—this situation is really tough. On top of that, I deal with autoimmune problems and dysautonomia, so things are even harder.
That compound is completely new to me, but I'd really like to find out more about it and hear what your research turned up. Can it be obtained somewhere, or is it still in studies? My goal is to keep her moving as much as possible while lowering the ever-present chance she takes a fall or gets hurt. Getting her to take in adequate protein and nutrients is another struggle.
That's the reason I brought up those ingredients earlier—they can be blended into 1 liquid shake or broth, then taken through a straw so there's less need to swallow.
Blvr7 said:
Smiter said:
Blvr7 said:
Hi everyone — I'm reaching out on behalf of my mom, who lives with a neurodegenerative condition: progressive supranuclear palsy, PSP. It falls under parkinsonism, and the underlying cause is tau protein accumulating in the brain. The main things she deals with are rigidity in the muscles, weakness, balance problems, incontinence, bradykinesia, difficulties with swallowing and her voice, plus frontal lobe shrinkage that brings memory loss and cognitive decline.
Gaining weight and building muscle is what she needs — losing weight is not a goal for her at all. From what I've dug up so far, the only candidates that seemed potentially workable were SS – 31 and Pinealon, though neither has much solid evidence for this kind of use. Cerebrolysin also crossed my radar, but with so little human data and the requirement for IV administration, it looks out of reach.
I want to do anything I can for her, yet money is tight — I'm her full-time caregiver and have no income to spend on kits. Keeping her injections and side effects to a minimum matters a lot to me. Any thoughts or personal experiences from people who know peptides well would mean the world — what might actually help her or support healing?
Has RI‐AG03, the ab76128 blocker peptide (ab211410), been something you've explored?
Hydrolysed whey, collagen, creatine, vitamin C, and Niacin.
One of my students based in Canada came up with an AI tool that identifies parkinson's via voice recognition. I assisted him with his research. While doing that, we explored possible routes for symptom treatment and how AI might play a role there. Here, the main hurdle is the difficulty surrounding IV dosage. Still, if nutrition supports muscle protein synthesis adequately, IGF-1 together with a myostatin inhibitor might at minimum slow the loss of muscle. Additionally, consider resistance bands and grippers, so that exercise can drive myokines such as BDNF. That's why Cerebrolysin performs well. Even so, BDNF and myokines originating from skeletal muscle do have a neurotrophic effect. That said, all of these only mitigate; none resolve. I'm sorry about your mom, and respect to you for caring for her. Respect!
,
I appreciate it—this situation is really tough. On top of that, I deal with autoimmune problems and dysautonomia, so things are even harder.
That compound is completely new to me, but I'd really like to find out more about it and hear what your research turned up. Can it be obtained somewhere, or is it still in studies? My goal is to keep her moving as much as possible while lowering the ever-present chance she takes a fall or gets hurt. Getting her to take in adequate protein and nutrients is another struggle.
Correct, both of those compounds exist and are currently under study. Just run a quick google search. I recall these 2 from his research. One was offered by Medchem express, and the other cost around 60 dollars.
Blvr7 said:
Smiter said:
Blvr7 said:
Hi everyone — I'm reaching out on behalf of my mom, who lives with a neurodegenerative condition: progressive supranuclear palsy, PSP. It falls under parkinsonism, and the underlying cause is tau protein accumulating in the brain. The main things she deals with are rigidity in the muscles, weakness, balance problems, incontinence, bradykinesia, difficulties with swallowing and her voice, plus frontal lobe shrinkage that brings memory loss and cognitive decline.
Gaining weight and building muscle is what she needs — losing weight is not a goal for her at all. From what I've dug up so far, the only candidates that seemed potentially workable were SS – 31 and Pinealon, though neither has much solid evidence for this kind of use. Cerebrolysin also crossed my radar, but with so little human data and the requirement for IV administration, it looks out of reach.
I want to do anything I can for her, yet money is tight — I'm her full-time caregiver and have no income to spend on kits. Keeping her injections and side effects to a minimum matters a lot to me. Any thoughts or personal experiences from people who know peptides well would mean the world — what might actually help her or support healing?
Has RI‐AG03, the ab76128 blocker peptide (ab211410), been something you've explored?
Hydrolysed whey, collagen, creatine, vitamin C, and Niacin.
One of my students based in Canada came up with an AI tool that identifies parkinson's via voice recognition. I assisted him with his research. While doing that, we explored possible routes for symptom treatment and how AI might play a role there. Here, the main hurdle is the difficulty surrounding IV dosage. Still, if nutrition supports muscle protein synthesis adequately, IGF-1 together with a myostatin inhibitor might at minimum slow the loss of muscle. Additionally, consider resistance bands and grippers, so that exercise can drive myokines such as BDNF. That's why Cerebrolysin performs well. Even so, BDNF and myokines originating from skeletal muscle do have a neurotrophic effect. That said, all of these only mitigate; none resolve. I'm sorry about your mom, and respect to you for caring for her. Respect!
,
I appreciate it—this situation is really tough. On top of that, I deal with autoimmune problems and dysautonomia, so things are even harder.
That compound is completely new to me, but I'd really like to find out more about it and hear what your research turned up. Can it be obtained somewhere, or is it still in studies? My goal is to keep her moving as much as possible while lowering the ever-present chance she takes a fall or gets hurt. Getting her to take in adequate protein and nutrients is another struggle.
which is exactly why resistance bands matter so much. they can be used while seated. Also check out Nikolai Tesla's toe exercises.
Oh, we've got the majority of those supplements on hand, plus no shortage of resistance bands and workout gear. Since apathy and motivation issues are such prominent features of PSP, coaxing her into doing almost anything can be really tough. My main priorities are hydration and protein, though I'll make more of an effort to work in some of the other suggestions. I need to track down those toe exercises!
I'm reading up on both, and they seem genuinely fascinating—riag03 in particular, since it stops tau from folding rather than merely cleaning up what's already happened. However, I'm not turning up much proof or documentation for use in humans. Does that "research" site function the same way the grey vendors do? $240 for 1mg strikes me as a bit outrageous. It sounds like the most promising route so far, and I'd really like to find out more. Thanks for your thoughts—you obviously know a lot about neurodegenerative medicine.
I also doubt that the strongest nootropics would be effective—otherwise I would have brought up Adamax, Semax, and similar options. The following comes from my personal notes. I purchased every one of these:
Noopept (omberacetam): a synthetic nootropic peptide created in Russia, intended to boost cognition, sharpen memory, and deliver neuroprotective advantages, with greater potency than piracetam. Its mechanism may involve raising acetylcholine signaling along with brain-derived neurotrophic factor (BDNF/NGF) levels. Users take it to enhance concentration, lower anxiety, and aid recovery after brain injury, typically at 10-30mg per day.
4'-DMA-7,8-DHF (Eutropoflavin): a synthetic relative of 7,8-dihydroxyflavone (7,8-DHF) that functions as a strong TrkB receptor agonist capable of crossing into the brain. It serves as a nootropic for memory, neurogenesis, and cognitive performance, with effects that are stronger and longer-lasting than 7,8-DHF. Typical doses are 10mg capsules.
9-Methyl-β-carboline (9-me-bc): a heterocyclic amine that acts as a potent
nootropic and neurorestorative compound. It inhibits MAO-A/B, promotes neurite outgrowth, and increases dopaminergic neurons in the brain, pointing to possible advantages for dopamine restoration, cognitive improvement, and neuroprotection.
PRL-8-53 (methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate): a synthetic nootropic research chemical noted for possible memory-boosting effects, particularly better verbal retention in studies. Dr. Nikolaus Hansl developed it in the 1970s as a phenethylamine derivative studied for cognitive enhancement, though the FDA has not approved it for human use.
Bemethyl (2-(ethylthio)-1H-benzimidazole): a Soviet-era actoprotector, antihypoxant, and mild psychostimulant meant to raise physical endurance, improve mental work capacity, and strengthen resistance to hypoxia and stress. Originally made for cosmonauts and soldiers, it triggers RNA/protein synthesis to boost metabolic efficiency.
Methylene blue: a synthetic dye with FDA approval for treating
methemoglobinemia (a rare blood oxygen disorder) and as a diagnostic stain. It functions as a redox agent to restore oxygen delivery. Although it is sometimes used off-label for cognitive enhancement and energy, combining it with antidepressants can risk serotonin syndrome because of its
MAOI properties, so medical supervision is essential. Cognitive Enhancement: Studied for improved memory and focus.
- Mitochondrial Support: Believed to boost cellular energy production and reduce fatigue.
- Neuroprotection: Explored in research for potential neuroprotective effects
