From what I've looked into, the GI problems I ran into don't appear to be especially widespread. Roughly 2 days after the initial dose, severe bloating set in and stuck around for close to 4-5 weeks. It was rough — constant burping, plus a persistent sensation of gas being stuck. For years I've consumed a huge amount of unflavored sugar free carbonated water. That, combined with slower digestion, was 100% behind it. I cut back to just 1 or maybe 2 carbonated drinks per day and have felt a lot better ever since. Beyond that, there's the odd stomach discomfort or bathroom-related side effect, but nothing severe. My titration was gradual, beginning at 1mg, and I'm now at 4mg per week. I've lost around 11 pounds, though I've likely gained 1 to 2 pounds of muscle, since I resumed lifting and upped my protein when I started the Reta.