Elora way better for me than Cagri 👍🏻

lessthanhalf said:

Grogu said:

I'm in week 3 or 4 of elora (my record-keeping is pretty sloppy 🤔) and figured I'd share that, side-effect wise, eloralintide beats cagrilintide by a mile for me. Cagri gave me some really odd bouts of mental fatigue, and elora hasn't produced anything like that. My doses went 1mg, then 1.5mg, and 2mg this week. I intend to keep titrating up to 3mg and see how that goes.

As far as food supression goes, it feels about the same as cagri did. But honestly, for me it isn't really food supression or quieting of food noise. Total satiation all the time is closer to what I'd call it. It's easy to understand why the rats in the elora rat study didn't eat anything for a week. These last few weeks I've had to remind myself to eat. Picture the way you feel after Thanksgiving dinner, once you've eaten a big meal and the very last thing you'd want is to stuff something else in your mouth. That feeling, minus the bloat. 🤣

The best part is that there is no upper GI sides. So, I can eat (if I want) without nausea, vomiting, etc.
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Thanks for sharing this helpful firsthand account. Since the incidence appears quite low at smaller doses but not low at all above 3mg, it's tough to predict what the side effects could be. I also saw that the rats pretty much quit eating for 1 week once it was combined with tirz.
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My hope is that going above 3mg won't be necessary. Figuring out the human dose equivalents from that rat study was tough for me, though my understanding is that it involved the maximum dose equivalents for both tirz and Elora. That would explain why the rats went a whole week without eating... Even at these low doses, my appetite is pretty much gone.
 
So far, per Jano, just a single vendor has actually paid for and published complete testing.

There are 3 separate COAs, and 1 of them includes structure.

Seems like the structural analysis with the full report needed an additional month to come through.

Image result in www.google.com/search?q=+peptides+eloralintide+bridge+expected

You can find the results publicly on their site, though registration is required.

For 1 vial, the cost runs roughly the same as a kit.
 
Grogu said:


What made you decide to switch from cagri?

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That's something I've been wondering too. Right now you're looking at roughly 170 USD for 10 vials of 5mg each. That's a lot of money. At 3mg per pin, you're paying 15 USD every time. That's insane. Cagri, on the other hand, only needs 25 mcg. So a single 5mg vial goes a very long way.
 
Kyli said:


I also have the same question. Because the current price is about 170 USD for 10x 5mg Vials. This is expensive. When you need 3mg per pin, that's 15 USD. It's insane. Whereas you use just 25 mcg of Cagri. So even a 5mg vial last a long time.

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Yeah, elora costs a lot more than cagri, but I'm guessing you meant 250 mcg? A 25 mcg dose would be tiny.

When it comes to Elora, for me the appeal is getting in early, since the price should drop if (and when) more suppliers can consistently make it. That's going to happen eventually — the only question is how long it takes. And even at today's steep prices, it still beats anything that would ever come out of the pharma world or even compounding. So personally, being able to try this new medication ahead of everyone else feels pretty great.
 
Grogu said:


Yes, cagri is pretty inexpensive compared to elora, but I think you meant 250 mcg, right? 25 mcg would be a pretty small dose.

As far as Elora, to me it's about early access as the cost will likely go down, if (and when), more sources are able to reliably produce the product. It will happen, it's just a matter of how long it will take. But even with the current high prices, it's still "better" than anything we'd ever see in the pharma space or even compound. So to me, to have early access to this new medication is pretty cool.

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Are Cagri and Elora not pretty much the same in how they work?
 
spanky2026 said:


Don't Cagri and Elora function in very similar ways?

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I agree with @Spork, and there's another point worth mentioning: eloralintide's half-life is considerably longer than cagri's.

For cagrilintide, the half-life that gets reported is roughly 7–8 days, and peak concentrations show up 1 to 3 days post-injection. Eloralintide sits closer to a 2-week half-life, and peak concentrations might not be reached until about 3 to 5-and-a-half days after injecting.

Because of that longer half-life, eloralintide should in theory give a flatter concentration curve across the week, more buildup from 1 weekly dose to the next, an apparent onset that is slower, and a washout after stopping that is substantially slower. The relatively stable concentrations plus the more targeted AMY-1 activation are most likely the reason eloralintide may come with fewer side effects than cagrilinitide. And lastly, elora is a far more complex molecule than cagri, which makes manufacturing the peptide harder.
 
Grogu said:


What @Spork said and I would add that eloralintide also has a substantially longer half-life than cagri.

Cagrilintide’s reported half-life is about 7–8 days, with peak concentrations occurring one to three days after injection. Eloralintide’s half-life is closer to two weeks, and it may not reach peak concentrations until approximately three to five-and-a-half days after injection.

This longer half-life means that eloralintide should theoretically produce a flatter weekly concentration curve, more accumulation from one weekly dose to the next, a slower apparent onset, and a substantially slower washout after stopping. The more targeted AMY-1 activation and the relatively stable concentrations are most likely why eloralintide may have less side effects than cagrilinitide. Finally, elora is a much more complex molecule than cagri, which makes the peptide more difficult to manufacture.

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That's interesting. My reaction to Cagri was allergic enough (not anaphylaxis, but a clear allergic response, twice) that I now feel hesitant about Elora too — though I'm still curious.
 
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