Looking for advice on expanding my stack — convince me!

Right now I'm using Reta and Klow, and the results have been great. I lift weights around 5 times a week and do a bit of running too.

I'm thinking about adding another compound, possibly:

SS31 + MOTSC

Or

Tesa + Ipa

If you have other ideas beyond these, or protocols you've personally found reliable, I'd really appreciate hearing them!

Thanks in advance!

I'd like to hear the recommendations you receive. Right now I'm using tirz and intend to move to reta+KLOW in January.

I chose to add MOTS-C while already taking Reta, and it left me flattened by intense fatigue for several days. Somewhere online I came across a suggestion to use SS31 ahead of the MOTS — the reasoning being that 31 is a repair peptide while MOTS is a mitochondrial optimization one — and the difference was remarkable.

These days I take them together, though it still makes sense in my head to do SS31 for a week or two before starting MOTS, just to tidy things up a bit beforehand. Your mileage may vary.

My cleanup protocol: 2mg of SS31 every day for 20 days.

On day 21 I brought in 2mg of MOTS on M/W/F and aligned the SS31 to that same schedule, still at 2mg. They combine without issue, which means one less needle.

No sudden surge of energy or anything like that, but my workouts became noticeably easier and I could push harder. Recovery stayed roughly the same.

For reference, here is the rest of what I run:

6mg Reta (Saturday)

1mg Tirz (to cut food noise, Tuesday)

2mg each SS31/MOTS - M/W/F

50mg NAD+ M/W/F

0.5mg each BPC157/TB500 daily

I did see a clear lift in overall energy after adding the NAD+, so that one is staying. The BPC/TB is for an ongoing shoulder strain that has mostly healed by now. I haven't decided how long I'll keep that one going.

I've never tried Tesa, but I did experiment with CJC/IPA for a stretch until an allergic reaction started developing, so I stopped it before it could escalate into full anaphylaxis. I suppose I'm one of the "lucky" ones with that compound.

LetsGoWolves said:

I'd like to hear the recommendations you receive. Right now I'm using tirz and intend to move to reta+KLOW in January.

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No matter which GLP you're on, klow can absolutely be run alongside it. Strongly suggest it

I stay on Reta or Tirz for maintenance. I've run a few 60 day KLOW cycles, alternating them with the well-known 8 week SS32-NAD-MotsC-5Amino 1MQ protocol. Both give me what I'd call perceived value, and I've got enough stocked to run several more cycles of each. If I had to suggest just one to begin with, KLOW would be my pick since it does more for me — though the two serve very different goals. I don't stack them; I alternate. Whether I'll restock once I run out is uncertain. KLOW, probably yes; S31/MotsC/etc., probably not.

I also have a kit of Tesa/Ipa sitting unused. My latest bloodwork showed Z-scores of 1.8 and 2.0, and I already lean toward carpal tunnel.

On paper, Tesa and Ipa make a solid pair because each acts on a different side of the GH pulse — Tesa is a GHRH analogue, while Ipa works as a ghrelin-receptor agonist — so combining them usually produces a larger pulse than either would on its own. What Tesa is really known for is visceral fat; it's the one with actual approval behind it for that use, so if leaning out is your priority, it likely fits you better than SS-31/MOTS-c. I've only used Ipa with CJC rather than with Tesa, so I can't offer a head-to-head comparison, but Ipa is about as low-drama as GH peptides come. The standard approach is to dose on an empty stomach before bed so that food doesn't blunt the pulse.

Cheesin said:


I am currently running Reta and Klow and love the effects that I am getting. I workout 5 ish times per week lifting weights and some running.

I want to add something else maybe like:

SS31 + MOTSC

Or

Tesa + Ipa

Does anyone have any suggestions other than those or any tried and true protocols that you would recommend!

Thanks in advance!

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Are you after justification for trying random peptides such as SS31, MOTSC, Tesa, Ipa?....or do you have particular effects from each that you're hoping to gain?...

Begin with whatever you already understand about each one and the effect you want from it, then build from there...

Flash-BCR said:

Are you after justification for trying random peptides such as SS31, MOTSC, Tesa, Ipa?....or do you have particular effects from each that you're hoping to gain?...

Begin with whatever you already understand about each one and the effect you want from it, then build from there...

Click to expand...

Random? Not at all.

I want to boost cellular energy and metabolic function using an SS-31/MOTS-c protocol. On top of that, the possible visceral-fat-burning effects and sleep improvements from a tesamorelin/ipamorelin (Tesa-Ipa) protocol or stack appeal to me.

These options have been researched thoroughly on my end, and the protocols I picked are the ones that interest me. What I'm after is input from folks with deeper expertise or experience — particularly suggestions or firsthand accounts involving either protocol — so I can learn more and see the bigger picture.

For instance: is it better to run SS-31 ahead of MOTS-c, or could tesamorelin be used by itself? And so on.

AICAR worked better for me than MOTS. I plan to keep trialing additional mitochondrial compounds. ATX 304 and SLUPP915 are up next. If I'm feeling adventurous, I might add BAM15.